A Study to Investigate Outcomes With Elecoglipron Compared With Placebo in Adult Participants With Chronic Kidney Disease.

Part of paid clinical trials in Huntsville, Alabama.

Sponsor
AstraZeneca
Study ID
NCT07753993
Phase
PHASE3
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Elecoglipron — DRUG
    Elicoglipron tablet
  • Placebo — DRUG
    Placebo tablet

Study Details

This is a Phase III, randomized, double-blind, parallel-group, placebo-controlled multicenter study to investigate outcomes with elecoglipron compared with placebo in participants with CKD with and without T2DM who are on background SGLT2i (dapagliflozin) as GDMT and other SoC treatments for CKD.

Key Dates

First listed
Aug 10, 2026
Start date
Aug 21, 2026
Status verified
Sep 2026
Primary completion
Oct 4, 2030
Completion
Oct 4, 2030

Study Design

Enrollment
7,000 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Elecoglipron
    Elecoglipron tablet once daily
  • Active Comparator: Placebo
    Placebo matching Elecoglipron tablet once daily

Primary Outcome Measure

To evaluate the effect of elecoglipron compared with placebo in reducing the risk of the composite of ≥ 50% sustained decline in eGFR, ESKD, or all-cause mortality [ Time Frame: Event-driven, trial is estimated to be up to 4.5 years ]

Central Contacts

Locations (120)

FacilityCityStateZIPSite coordinators
Research SiteHuntsvilleAlabama35801-
Research SiteMontgomeryAlabama36117-
Research SiteSheffieldAlabama35660-
Research SitePeoriaArizona85382-
Research SitePhoenixArizona85012-
Research SiteSurpriseArizona85374-
Research SiteLittle RockArkansas72205-
Research SiteChula VistaCalifornia91910-
Research SiteConcordCalifornia94520-
Research SiteDaly CityCalifornia94015-
Research SiteFremontCalifornia94538-
Research SiteHuntington BeachCalifornia92647-
Research SiteHuntington ParkCalifornia90255-
Research SiteLomitaCalifornia90717-
Research SiteNational CityCalifornia91950-
Research SiteNorthridgeCalifornia91324-
Research SiteNorthridgeCalifornia91325-
Research SiteRolling Hills EstatesCalifornia90274-
Research SiteSan DiegoCalifornia92111-
Research SiteSan FranciscoCalifornia94110-
Research SiteSan MateoCalifornia94403-
Research SiteTarzanaCalifornia91356-
Research SiteArvadaColorado80002-
Research SiteDenverColorado80220-
Research SiteHartfordConnecticut06112-
Research SiteMiddleburyConnecticut06762-
Research SiteWaterburyConnecticut06708-
Research SiteBoca RatonFlorida33487-
Research SiteBoynton BeachFlorida33435-
Research SiteCutler BayFlorida33157-
Research SiteFort LauderdaleFlorida33316-
Research SiteHollywoodFlorida33024-
Research SiteJacksonville BeachFlorida32250-
Research SiteJensen BeachFlorida34957-
Research SiteLauderdale LakesFlorida33313-
Research SiteLongwoodFlorida32750-
Research SiteMelbourneFlorida32901-
Research SiteMiamiFlorida33125-
Research SiteMiamiFlorida33135-
Research SiteOcoeeFlorida34761-
Research SiteOrlandoFlorida32806-
Research SitePensacolaFlorida32503-
Research SitePort CharlotteFlorida33952-
Research SiteRiverviewFlorida33578-
Research SiteAustellGeorgia30106-
Research SiteColumbusGeorgia31904-
Research SiteEast PointGeorgia30344-
Research SiteTuckerGeorgia30084-
Research SiteChampaignIllinois61820-
Research SiteChicagoIllinois60611-
Research SiteChicagoIllinois60640-
Research SiteRockfordIllinois61107-
Research SiteTinley ParkIllinois60477-
Research SiteAmesIowa50010-
Research SiteTopekaKansas66606-
Research SiteBeltsvilleMaryland20705-
Research SiteBostonMassachusetts02115-
Research SiteNew BedfordMassachusetts02740-
Research SiteDetroitMichigan48207-
Research SiteFlintMichigan48532-
Research SiteSaginawMichigan48604-
Research SiteSaint JosephMichigan49085-
Research SiteSouthfieldMichigan48075-
Research SiteTroyMichigan48098-
Research SiteMinneapolisMinnesota55435-
Research SiteMinneapolisMinnesota55435-
Research SiteBrookhavenMississippi39601-
Research SiteChesterfieldMissouri63005-
Research SiteLas VegasNevada89101-
Research SiteLas VegasNevada89107-
Research SiteLas VegasNevada89146-
Research SiteEatontownNew Jersey07724-
Research SiteJersey CityNew Jersey07306-
Research SiteAlbuquerqueNew Mexico87106-
Research SiteAlbanyNew York12205-
Research SiteBrooklynNew York11220-
Research SiteBuffaloNew York14215-
Research SiteMineolaNew York11501-
Research SiteGreensboroNorth Carolina27405-
Research SiteMorehead CityNorth Carolina28557-
Research SiteRocky MountNorth Carolina27804-
Research SiteShelbyNorth Carolina28150-
Research SiteStatesvilleNorth Carolina28625-
Research SiteWilmingtonNorth Carolina28401-
Research SiteWilmingtonNorth Carolina28403-
Research SiteCincinnatiOhio45212-
Research SiteMaumeeOhio43537-
Research SitePortlandOregon97202-
Research SiteBeaverPennsylvania15009-
Research SiteExtonPennsylvania19341-
Research SiteIndianaPennsylvania15701-
Research SiteMediaPennsylvania19063-
Research SitePhiladelphiaPennsylvania19107-
Research SitePlymouth MeetingPennsylvania19462-
Research SiteEast ProvidenceRhode Island02914-
Research SiteProvidenceRhode Island02903-
Research SiteRapid CitySouth Dakota57701-
Research SiteKnoxvilleTennessee37912-
Research SiteMorristownTennessee37813-
Research SiteArlingtonTexas76015-
Research SiteDallasTexas75246-
Research SiteEl PasoTexas79902-
Research SiteHoustonTexas77036-
Research SiteHoustonTexas77040-
Research SiteHoustonTexas77054-
Research SiteLubbockTexas79430-
Research SiteMcKinneyTexas75071-
Research SiteMesquiteTexas75149-
Research SiteParisTexas75462-
Research SitePasadenaTexas77504-
Research SiteSan AntonioTexas78212-
Research SiteSan AntonioTexas78230-
Research SiteSan AntonioTexas78251-
Research SiteShenandoahTexas77384-
Research SiteSugar LandTexas77479-
Research SiteSouth Salt LakeUtah84115-
Research SiteBurlingtonVermont05401-
Research SiteArlingtonVirginia22205-
Research SiteNorfolkVirginia23502-
Research SiteSeattleWashington98122-

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