Dynamics of Wound Healing in Patients With Obesity

Part of paid clinical trials in Iowa City, Iowa.

Sponsor
University of Iowa
Study ID
NCT07756112
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 70 Years
Healthy Volunteers
Not accepted

Interventions

  • Collagen Plug (standard of care) — PROCEDURE
    Collagen Plug (standard of care)
  • Platelet-Rich Fibrin Clot — PROCEDURE
    Platelet-Rich Fibrin Clot is placed on wound

Study Details

Healing after dental surgery can vary from person to person. This study is being done to understand how body weight (obesity vs. normal weight) may affect healing after tissue is removed from the roof of the mouth during a gum graft procedure. The study will also evaluate whether a healing material made from a participant's own blood, called platelet-rich fibrin (PRF), is comparable in quantity and quality to the standard-of-care collagen plug. First, participants will be classified into obese or normal weight groups. Next, participants will be randomized to receive either collagen plug or platelet-rich fibrin clot during their surgical procedure Then, participants will return for 4 visits up to 30 days from the surgery visit.

Key Dates

First listed
Aug 10, 2026
Start date
Aug 31, 2026
Status verified
Jul 2026
Primary completion
Aug 31, 2029
Completion
Aug 31, 2029

Study Design

Enrollment
104 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Normal Weight Patients with Collagen Plug
  • Experimental: Normal Weight Patients with Platelet-Rich Fibrin Clot
  • Active Comparator: Obese Weight Patients with Collagen Plug
  • Experimental: Obese Weight Patients with Platelet-Rich Fibrin Clot

Primary Outcome Measure

Change in Growth Factor Quality between Normal and Obese Patients who received either Platelet-Rich Fibrin Clot or Collagen Plug at 30 days after baseline [ Time Frame: Baseline, 30 days after baseline ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Iowa College of Dentistry and Dental ClinicsIowa CityIowa52242
Sukirth M Ganesan
[email protected]
(319) 467-1475

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By research site
University of Iowa College of Dentistry and Dental Clinics· Iowa City, IA

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