Randomized Evaluation of Operating Room Extubation After Cardiac Surgery

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Massachusetts General Hospital
Study ID
NCT07757880
Status
Not Yet Recruiting

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Conditions

  • Cardiac Surgery

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • OR extubation — PROCEDURE
    Immediate extubation in the operating room (OR) at the conclusion of cardiac surgery
  • ICU extubation — PROCEDURE
    Extubation in the intensive care unit (ICU) within 6 hours of leaving the operating room after cardiac surgery

Study Details

We are studying whether waking patients up and removing the breathing tube (also known as "extubation") in the operating room after cardiac surgery improves postoperative recovery without causing harm.

Key Dates

First listed
Aug 11, 2026
Start date
Aug 31, 2026
Status verified
Aug 2026
Primary completion
Feb 28, 2027
Completion
Mar 31, 2027

Study Design

Enrollment
120 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: OR extubation
    Extubation in the operating room (OR) at the conclusion of cardiac surgery
  • Placebo Comparator: ICU extubation
    Extubation in the intensive care unit (ICU) within 6 hours of leaving the OR

Primary Outcome Measure

Hierarchical composite endpoint, ordered by clinical priority [ Time Frame: 15 days postoperatively ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Brigham and Women's HospitalBostonMassachusetts02115
Chinyere Archie, MBBS
[email protected]
6034962892
Massachusetts General HospitalBostonMassachusetts02141
Jordan Bloom, MD, MPH
[email protected]
617-643-6058

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By research site
Brigham and Women's Hospital· Boston, MAMassachusetts General Hospital· Boston, MA

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