Dynamic Functional Imaging Phenotyping and Disease Progression Risk Assessment in COPD Using Dynamic Chest Radiography: A Multicenter Retrospective Study

Sponsor
Nanfang Hospital, Southern Medical University
Study ID
NCT07762573
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
30 Years - 85 Years
Healthy Volunteers
Not accepted

Study Details

To evaluate the utility of DCR-derived parameters for identifying dynamic functional imaging phenotypes, assessing disease severity, and predicting the risk of disease progression in COPD.

Key Dates

First listed
Aug 13, 2026
Start date
Aug 3, 2026
Status verified
Aug 2026
Primary completion
Dec 30, 2029
Completion
Jan 30, 2030

Study Design

Enrollment
2,500 participants (estimated)

Arms

  • Arm: COPD group
    any patient who complains of dyspnea, chronic cough or sputum, a history of recurrent lower respiratory infection and/or a history of exposure to disease risk factors, Pulmonary function examination indicated that FEV1/FVC \<0.7 after bronchodilator was used to confirm COPD.
  • Arm: PRISM group
    After bronchial dilation, FEV1/FVC was ≥0.70, and FEV1%PRED was \<80%.
  • Arm: Smoking exposure groups
    Smoking history of 10 years, or without COPD, pulmonary function of COPD diagnosis standard.
  • Arm: Normal control group
    Never-smokers without airflow limitation and with normal pulmonary function.

Primary Outcome Measure

Exacerbation/respiratory history and event [ Time Frame: At Baseline ]

Central Contacts

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