Neuromodulation for Patients With Parkinson's Disease

Conditions

• Adults With Parkinson's Disease

Eligibility Criteria

Sex

ALL

Age

40 Years - 85 Years

Healthy Volunteers

Not accepted

Interventions

• tDCS combined with TUS — DEVICE
  This study will compare different treatment schedules of combined transcranial direct current stimulation (tDCS) and transcranial ultrasound stimulation (TUS) in participants with Parkinson's disease.

Study Details

This study will compare different treatment schedules of combined transcranial direct current stimulation (tDCS) and transcranial ultrasound stimulation (TUS) in participants with Parkinson's disease. Participants will be randomly assigned to one of four groups: Standard (10 sessions delivered five times per week for two weeks), Distributed (six sessions delivered three times per week for two weeks), Short (five sessions delivered over one week), or Sham (10 sham sessions delivered five times per week for two weeks).

Key Dates

First listed

Aug 17, 2026

Start date

Oct 1, 2026

Status verified

Aug 2026

Primary completion

Jun 30, 2031

Completion

Jun 30, 2032

Study Design

Enrollment

116 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: Standard Protocol
  tDCS combined with TUS for 10 sessions; 5/week for 2 weeks
• Active Comparator: Distributed Protocol
  tDCS and TUS for 6 sessions; 3/week for 2 weeks
• Active Comparator: Short Protocol
  tDCS and TUS for 5 sessions over 1 week
• Sham Comparator: Sham
  Sham stimulation for 10 sessions; 5/week for 2 weeks

Primary Outcome Measure

Improvement in Unified Parkinson's Disease Rating Scale (UPDRS) Part III [ Time Frame: Baseline-adjusted change in UPDRS Part III from end-of-stimulation through 12 weeks. ]

Central Contacts

• Felipe Fregni
  6179526154
  [email protected]

Locations (1)

Find similar trials in Cambridge, MA