Effects of Flavonoid Foods on Carbonyl Stress

Conditions

• Carbonyl Stress
• Flavonoids
• Human Health

Eligibility Criteria

Sex

ALL

Age

25 Years - 70 Years

Healthy Volunteers

Accepted

Interventions

• High-Flavonoid Diet — DIETARY_SUPPLEMENT
  Participants will consume the high-flavonoid diet daily for 3 weeks. The diet includes 1 Red Delicious apple (approximately 160 g), freeze-dried whole blueberry powder (25 g), soy milk (240 mL), and decaffeinated Lipton green tea ( 2 g tea leaves), providing approximately 420 mg flavonoids per day.
• Low-Flavonoid Diet — DIETARY_SUPPLEMENT
  Participants will consume the low-flavonoid diet daily for 3 weeks. The diet includes 1/3 of Red Delicious, 107 g of pineapple; 8.3 g of blueberry powder plus 16.7 g of blueberry placebo powder; 80 mL of soy milk plus 160 mL of 2% low-fat milk; and 0.67 g tea leaves, providing approximately 140 mg flavonoids per day.

Study Details

This randomized crossover study will compare low- and high-flavonoid diets in healthy adults to identify flavonoid-derived biomarkers in urine and plasma. Using targeted LC-MS metabolomics, researchers will measure known and novel flavonoid metabolites and evaluate whether a higher flavonoid intake reduces carbonyl stress markers, including reactive carbonyl species (RCS) and advanced glycation end products (AGEs).

Key Dates

First listed

Aug 17, 2026

Start date

Sep 2, 2026

Status verified

Aug 2026

Primary completion

Oct 15, 2027

Completion

Dec 31, 2027

Study Design

Enrollment

36 participants (estimated)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Arms

• Experimental: High-Flavonoid Diet, Then Low-Flavonoid Diet
  All participants will first complete a 2-week low-flavonoid wash-in period. Participants in this sequence will then consume the high-flavonoid diet for 3 weeks, complete a 3-week low-flavonoid washout period, and then consume the low-flavonoid diet for 3 weeks.
• Experimental: Low-Flavonoid Diet Followed by High-Flavonoid Diet
  All participants will first complete a 2-week low-flavonoid wash-in period. Participants in this sequence will then consume the low-flavonoid diet for 3 weeks, complete a 3-week low-flavonoid washout period, and then consume the high-flavonoid diet for 3 weeks.

Primary Outcome Measure

Plasma and Urine Flavonoid Metabolites [ Time Frame: After the 3-week dietary intervention period. ]

Central Contacts

• Shengmin Sang
  704-250-5710
  [email protected]

Locations (1)

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