Biomarkers of Cervical Spondylotic Myelopathy

Part of paid clinical trials in San Francisco, California.

Sponsor
University of California, San Francisco
Study ID
NCT07772297
Status
Not Yet Recruiting

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Conditions

  • Cervical Spondylotic Myelopathy

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Study Details

Investigators believe that patients with cervical spondylotic myelopathy (CSM) have measurable changes in certain molecules in their blood compared with people without CSM. Investigators expect that these changes may be related to how severe a patient's condition is based on imaging and clinical exams. Investigators will also study how these molecules change before and after surgery to see whether they are related to how well patients recover. By combining these blood markers with clinical and imaging information, investigators hope to develop a tool that may help predict patient outcomes.

Key Dates

First listed
Aug 19, 2026
Start date
Sep 30, 2026
Status verified
Aug 2026
Primary completion
Sep 30, 2028
Completion
Sep 30, 2030

Study Design

Enrollment
50 participants (estimated)

Arms

  • Arm: CSM
    All Adults over age of 18, with a diagnosis of/encompassed by/related to cervical spondylotic myelopathy, cervical myelopathy, or ossification of posterior longitudinal ligament.
  • Arm: Healthy, non-CSM
    Adults over age of 18, with no neck pain, radiculopathy, or myelopathy symptoms, and no trauma in the past 6 months. Does not meet exclusion criteria.

Primary Outcome Measure

Diagnostic performance of serum RNA biomarkers for CSM [ Time Frame: Preoperative/baseline visit ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UCSF Medical CenterSan FranciscoCalifornia94143
Danielle Nieto, BA
[email protected]
415-476-5199
Nima Alan, MD (PRINCIPAL_INVESTIGATOR)
Ethan Winkler, MD, PhD (SUB_INVESTIGATOR)
Lee Tan, MD (SUB_INVESTIGATOR)
Praveen Mummaneni, MBA, MD (SUB_INVESTIGATOR)
Jang Yoon, MD (SUB_INVESTIGATOR)

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UCSF Medical Center· San Francisco, CA