Imaging Mitochondrial Complex-I in Cocaine Use Disorder: a [F-18]BCPP-EF PET Study

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
Rajesh Narendran
Study ID
NCT07773649
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

  • Cocaine Use Disorder
  • Healthy Controls Group - Age and Sex-matched

Eligibility Criteria

Sex
ALL
Age
18 Years - 45 Years
Healthy Volunteers
Accepted

Interventions

  • [F-18]BCPP-EF — DRUG
    Radiotracer

Study Details

Studies proposed in this application will image mitochondrial Complex-I in cocaine use disorder (CUD) and matched healthy controls

Key Dates

First listed
Aug 19, 2026
Start date
Sep 15, 2026
Status verified
Aug 2026
Primary completion
Dec 31, 2029
Completion
Dec 31, 2029

Study Design

Enrollment
40 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: PET
    \[F-18\]BCPP-EF

Primary Outcome Measure

Orbitofrontal Cortex [F-18]BCPP-EF VT [ Time Frame: Baseline scan (time 0) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of PittsburghPittsburghPennsylvania15213-

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By research site
University of Pittsburgh· Pittsburgh, PA

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