Imaging Mitochondrial Complex-I in Alcohol Use Disorder

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
Rajesh Narendran
Study ID
NCT07825818
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

  • Alcohol Use Disorder (AUD)
  • Healthy Controls Group - Age and Sex-matched

Eligibility Criteria

Sex
ALL
Age
18 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • [F-18]BCPP-EF — DRUG
    Radiotracer to measure binding to mitochondria complex -I
  • [F-18]FDG — DRUG
    Radiotracer to measure cerebral glucose metabolism

Study Details

Studies proposed in this application will image mitochondrial Complex-I (MCI-I) and cerebral glucose metabolism (CGM) in alcohol use disorder (AUD) and matched healthy controls

Key Dates

First listed
Sep 17, 2026
Start date
Sep 30, 2026
Status verified
Sep 2026
Primary completion
Dec 31, 2032
Completion
Dec 31, 2032

Study Design

Enrollment
100 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: PET
    Positron Emission Tomography Scans

Primary Outcome Measure

Dorsolateral prefrontal cortex [F-18]BCPP-EF VT [ Time Frame: Baseline scan (time 0) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of PIttsburghPittsburghPennsylvania15213
Principal Investigator
[email protected]
412-647-5176

Find similar trials in Pittsburgh, PA

By research site
University of PIttsburgh· Pittsburgh, PA

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