A Study to Assess the Efficacy and Safety of GIA632 Across a Range of Doses in Participants With Moderate to Severe Cutaneous Lichen Planus

Conditions

• Cutaneous Lichen Planus

Eligibility Criteria

Sex

ALL

Age

18 Years - 99 Years

Healthy Volunteers

Not accepted

Interventions

• Placebo — DRUG
  Matching placebo
• GIA632 — DRUG
  GIA632 administered according to the assigned study treatment regimen.

Study Details

This study will evaluate the safety and efficacy of GIA632 in participants with moderate to severe cutaneous lichen planus (cLP).

Key Dates

First listed

Aug 20, 2026

Start date

Sep 10, 2026

Status verified

Aug 2026

Primary completion

Nov 22, 2028

Completion

Feb 13, 2030

Study Design

Enrollment

259 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Placebo Comparator: Placebo
  Participants will receive matching placebo according to the treatment regimen assigned at randomization during the study treatment period.
• Experimental: GIA632 - Treatment regimen 1
  Participants will receive GIA632 according to the treatment regimen assigned at randomization during the study treatment period.
• Experimental: GIA632 - Treatment regimen 2
  Participants will receive GIA632 according to the treatment regimen assigned at randomization during the study treatment period.
• Experimental: GIA632 - Treatment regimen 3
  Participants will receive GIA632 according to the treatment regimen assigned at randomization during the study treatment period.
• Experimental: GIA632 - Treatment regimen 4
  Participants will receive GIA632 according to the treatment regimen assigned at randomization during the study treatment period.

Primary Outcome Measure

Number of participants achieving an Investigator Global Assessment (IGA) response [ Time Frame: Week 16 ]

Central Contacts

• Novartis Pharmaceuticals
  1-888-669-6682
  [email protected]
• Novartis Pharmaceuticals
  +41613241111
  [email protected]

Locations (2)

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