A Double-Blinded Study on Rapid and Sustained Pain Relief Topical Cannabidiol for Plantar Fasciitis

Part of paid clinical trials in Gainesville, Florida.

Sponsor
University of Florida
Study ID
NCT07776405
Phase
PHASE1
Status
Not Yet Recruiting

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Conditions

  • Plantar Fasciitis

Eligibility Criteria

Sex
ALL
Age
18 Years - 85 Years
Healthy Volunteers
Accepted

Interventions

  • transdermal CBD cream (Tolcylen®, Marlinz Pharma) — DRUG
    The active product is the study CBD cream supplied by the manufacturer. Dosing is three pumps per application which delivers approximately one point five milliliters of cream. Application is once daily to the most tender plantar fascia region for the entire study month. The first dose will be taught and supervised in clinic using a glove. The cream will be massaged into the affected area for at least forty-five seconds. Skin must be clean and dry before application. No other topical agents may be placed on the study area during the study period.
  • Matched Placebos — DRUG
    The control group will receive a placebo cream identical in appearance, texture, scent, and packaging to the active product but containing no cannabidiol.

Study Details

This prospective, double-blinded, placebo-controlled study evaluates the efficacy of a 6000 mg transdermal CBD cream in adults with plantar fasciitis. Fifty participants will apply either CBD or placebo once daily for one month.

Key Dates

First listed
Aug 20, 2026
Start date
Sep 1, 2026
Status verified
Aug 2026
Primary completion
Mar 31, 2027
Completion
Mar 31, 2027

Study Design

Enrollment
50 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Participants who receive a transdermal cannabidiol cream
    Dosing is three pumps per application which delivers approximately one point five milliliters of cream. Application is once daily to the most tender plantar fascia region for the entire study month
  • Placebo Comparator: Participants who receive a matched placebo
    Dosing is three pumps per application which delivers approximately one point five milliliters of cream. Application is once daily to the most tender plantar fascia region for the entire study month

Primary Outcome Measure

• Immediate pain relief, measured by change in numeric rating scale (0-10) from baseline to ten minutes after supervised application. [ Time Frame: Daily for one month ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Florida Department of OrthopaedicsGainesvilleFlorida32611
Antony Merendino, DPM
[email protected]
352-273-7044
Shea Herlihy, MS
[email protected]
352-273-7361

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By research site
University of Florida Department of Orthopaedics· Gainesville, FL

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