A Study of Romosozumab in People With Breast Cancer and Osteoporosis

Part of paid clinical trials in Basking Ridge, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT07776613
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
FEMALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Romosozumab — DRUG
    Romosozumab will be given on-label at 210 mg administered SC once monthly for 12 months.

Study Details

The researchers are doing this study to see if romosozumab is effective at helping with bone formation in people with metastatic breast cancer (MBC) that has spread to the bones. All participants will have osteoporosis. The researchers will also look at bone breakdown (resorption) in participants and determine if romosozumab is a safe treatment for osteoporosis in people with MBC that has spread to the bones.

Key Dates

First listed
Aug 20, 2026
Start date
Aug 17, 2026
Status verified
Aug 2026
Primary completion
Aug 31, 2028
Completion
Aug 31, 2028

Study Design

Enrollment
25 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Romosozumab
    Romosozumab will be given on-label at 210 mg

Primary Outcome Measure

Percent change in Procollagen Type 1 N-telopeptide (P1NP ) levels [ Time Frame: 1 year ]

Central Contacts

Locations (7)

FacilityCityStateZIPSite coordinators
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)Basking RidgeNew Jersey07920
Monica Fornier, MD
6468884563
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)MiddletownNew Jersey07748
Monica Fornier, MD
646-888-5240
Memorial Sloan Kettering Bergen (Limited Protocol Activities)MontvaleNew Jersey07645
Monica Fornier, MD
646-888-5240
Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (Limited protocol activities)CommackNew York11725
Monica Fornier, MD
646-888-4563
Memorial Sloan Kettering Westchester (Limited Protocol Activities)HarrisonNew York10604
Monica Fornier, MD
646-888-4563
Memorial Sloan Kettering Cancer CenterNew YorkNew York10065
Monica Fornier, MD
646-888-5240
Jasmeet Singh, MD
914-367-7358
Memorial Sloan Kettering Nassau (Limited Protocol Activities)UniondaleNew York11553
Monica Fornier, MD
646-888-4563

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By research site
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)· Basking Ridge, NJMemorial Sloan Kettering Monmouth (Limited Protocol Activities)· Middletown, NJMemorial Sloan Kettering Bergen (Limited Protocol Activities)· Montvale, NJMemorial Sloan Kettering Cancer Center @ Suffolk-Commack (Limited protocol activities)· Commack, NYMemorial Sloan Kettering Westchester (Limited Protocol Activities)· Harrison, NYMemorial Sloan Kettering Cancer Center· New York, NY

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