Genetic of Skeletal Muscle Insulin Resistance

Part of paid clinical trials in San Antonio, Texas.

Sponsor
The University of Texas Health Science Center at San Antonio
Study ID
NCT07780513
Status
Recruiting
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Conditions

  • Insulin Stimulated

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Accepted

Interventions

  • Insulin 80mU/m2*min — OTHER
    80mU/m2\*min euglycemic-hyperinsulinemic clamp

Study Details

In this study, we will use euglycemic/hyperinsulinemic clamps, longitudinal skeletal muscle biopsies, and single nucleus RNA- and ATAC- sequencing to reveal cell type-specific molecular response Quantitative trait loci (rQTLs) acutely regulated by insulin signaling and glucose uptake.

Key Dates

First listed
Aug 21, 2026
Start date
Aug 31, 2026
Status verified
Aug 2026
Primary completion
Jul 31, 2031
Completion
Jul 31, 2031

Study Design

Enrollment
100 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Insulin stimulated
    80mU/m2\*min euglycemic/hyperinsulinemic clamp

Primary Outcome Measure

Cell type specific quantitative trait loci in skeletal muscle [ Time Frame: Before and after insulin clamp ( Baseline to approximately 6 hours) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Texas Diabetes Institute - University Health System, San Antonio, Texas 78207San AntonioTexas78229
Luke Norton, Ph.D
[email protected]
210-567-0739
[email protected]
Luke Norton, Ph.D (PRINCIPAL_INVESTIGATOR)

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Texas Diabetes Institute - University Health System, San Antonio, Texas 78207· San Antonio, TX