Tracing Of Real-time glu13Cose Metabolism in Human Immune Cells - Intensive Care Unit

Part of paid clinical trials in Nashville, Tennessee.

Sponsor
Vanderbilt University Medical Center
Study ID
NCT07811180
Status
Not Yet Recruiting

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Conditions

  • Critical Illness
  • Glucose
  • Immune System and Related Disorders
  • Intensive Care Unit (ICU)
  • Isotope Labeling
  • Metabolism
  • Sepsis

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • 13C6-Glucose — DRUG
    Compounded as 5% 13C6-glucose in water and given intravenously over 2-4 hours at a total dose of 10-25 grams.

Study Details

The purpose of this study is to understand how cells of the immune system use the common sugar glucose during critical illness. Investigators will intravenously infuse a non-radioactive carbon-13 glucose tracer into adult intensive care unit (ICU) participants over a few hours and collect immune cells from the blood to track uptake and usage of this glucose within these immune cells.

Key Dates

First listed
Sep 9, 2026
Start date
Nov 1, 2026
Status verified
Sep 2026
Primary completion
Oct 31, 2027
Completion
Mar 1, 2028

Study Design

Enrollment
25 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Other: 13C6-Glucose
    Participants will receive 10-25 grams of 13C6-glucose intravenously over 2-4 hours during a single ICU study procedure.

Primary Outcome Measure

13C6-Glucose Uptake and Metabolism in Immune Cells [ Time Frame: Up to 4 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Vanderbilt University Medical CenterNashvilleTennessee37212
Matthew T Stier, M.D., Ph.D.
[email protected]
615-875-4978
Matthew T Stier, M.D., Ph.D. (PRINCIPAL_INVESTIGATOR)

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Vanderbilt University Medical Center· Nashville, TN

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