Paid Clinical Trials in Tennessee

Tennessee has 2,077 paid clinical trials enrolling now across cities including Nashville, Memphis and Knoxville. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Tennessee include Vanderbilt University Medical Center and St. Jude Children's Research Hospital, running studies across oncology, cardiology, neurology, and more. The most actively recruiting conditions are Breast Cancer, Colorectal Cancer, Advanced Solid Tumor, Ovarian Cancer — browse the full list or use the filters to match your diagnosis. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 31, 2026.

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Healthy volunteers only

Newly added in Tennessee

Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.

Screen2Prevent (S2P)

for HIV Infections

Sites in Memphis +4 more locations

Sponsor: Westat

Sex: All·Age: 14 - 24·Accepts healthy volunteers

Code: NCT07728123·Recruiting·Listed Jul 27, 2026

Apply to this trial

A Study in Patients With Metastatic Castration-Resistant Prostate Cancer

for Metastatic Castration Resistant Prostate Cancer

Sites in Nashville +9 more locations

Sponsor: Flare Therapeutics Inc.

Sex: Male·Age: 18+

Code: NCT07719361·Phase 1·Recruiting·Listed Jul 22, 2026

Apply to this trial

An Open-label Study to Investigate the Efficacy and Safety of Dato-DXd + Rilvegostomig vs SoC in Adult Participants With High-risk MIUC

for High-risk Muscle Invasive Urothelial Carcinoma

Drug: Rilvegostomig

Sites in Nashville +17 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07720284·Phase 3·Recruiting·Listed Jul 22, 2026

Apply to this trial

A Study to Assess the Efficacy and Safety of Solriamfetol in Children With ADHD

for ADHD

Drug: Solriamfetol

Sites in Memphis +8 more locations

Sponsor: Axsome Therapeutics, Inc.

Sex: All·Age: 6 - 11

Code: NCT07717879·Phase 3·Recruiting·Listed Jul 21, 2026

Apply to this trial

A Study to Assess the Efficacy and Safety of Solriamfetol in Adolescents With ADHD

for ADHD

Drug: Solriamfetol

Sites in Memphis +8 more locations

Sponsor: Axsome Therapeutics, Inc.

Sex: All·Age: 12 - 17

Code: NCT07717892·Phase 3·Recruiting·Listed Jul 21, 2026

Apply to this trial

Post-market Cosmetic Evaluation of Ariessence™ Pure PDGF+ Following Ablative Laser

for Immediate Post-Treatment Care

Sites in Nashville +1 more location

Sponsor: Lynch Regenerative Medicine

Sex: All·Age: 40 - 70

Code: NCT07718347·Recruiting·Listed Jul 21, 2026

Apply to this trial

1,847 clinical trials

A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine

for Migraine

Drug: Elismetrep

Sites in Nashville, Chattanooga +112 more locations

Sponsor: Kallyope Inc.

Sex: All·Age: 18 - 75

Code: NCT07645924·Phase 3·Recruiting·Listed Jun 12, 2026

Apply to this trial

A Research Study Comparing How Well Different Doses of the Medicine UBT251 Lower Blood Sugar in People With Type 2 Diabetes

for Diabetes Mellitus, Type 2

Sites in Memphis +24 more locations

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18 - 75

Code: NCT07668388·Phase 2·Recruiting·Listed Jun 25, 2026

Apply to this trial

Study to Learn About Safety, Tolerability, and Immune Response of a Catch-up Pneumococcal Vaccine in Children and Adolescents

for Pneumococcal Disease

Sites in Tullahoma +42 more locations

Sponsor: Pfizer

Sex: All·Age: 15 Months - 17·Accepts healthy volunteers

Code: NCT07660198·Phase 3·Recruiting·Listed Jun 22, 2026

Apply to this trial

A Study to Learn About How a New Pneumococcal Vaccine Works in Infants.

for Pneumococcal Disease

Sites in Tullahoma +78 more locations

Sponsor: Pfizer

Sex: All·Age: 42 Days - 211 Days·Accepts healthy volunteers

Code: NCT07629440·Phase 3·Recruiting·Listed Jun 5, 2026

Apply to this trial

A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

for Obesity

Drug: NNC0487-0111

Sites in Jackson, Greeneville +204 more locations

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07567001·Phase 3·Recruiting·Listed May 2026

Apply to this trial

A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)

for Major Depressive Episode (MDE)

Sites in Mephis +24 more locations

Sponsor: Tonix Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT07621237·Phase 2·Recruiting·Listed Jun 2026

Apply to this trial

A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity (SOLIS-1)

for Overweight

Sites in Hendersonville +54 more locations

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07575932·Phase 2·Recruiting·Listed May 2026

Apply to this trial

A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

for Overweight

Drug: Eloralintide

Sites in Nashville +39 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT07589608·Phase 2·Recruiting·Listed May 2026

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A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight

for Obesity

Drug: Semaglutide

Sites in Nashville, Memphis +97 more locations

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07564414·Phase 3·Recruiting·Listed May 2026

Apply to this trial

A Study in People With Diabetic Macular Edema to Test How Well Different Doses of BI 3812465 Are Tolerated

for Diabetic Macular Edema

Sites in Nashville +28 more locations

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT07553429·Phase 1, Phase 2·Recruiting·Listed Apr 2026

Apply to this trial

An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)

for Cardiovascular Disease and Lipoprotein(a)

Drug: Pelacarsen

Sites in Nashville, Germantown +110 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT07517263·Phase 3·Recruiting·Listed Apr 2026

Apply to this trial

A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)

for Macular Degeneration

Sites in Nashville, Knoxville +48 more locations

Sponsor: EyeBiotech Ltd.

Sex: All·Age: 50+

Code: NCT07496567·Phase 2, Phase 3·Recruiting·Listed Mar 2026

Apply to this trial

A Phase 2/3 Study of Brepocitinib in Adults With Lichen Planopilaris

for Lichen Planopilaris

Sites in Murfreesboro, Smyrna +45 more locations

Sponsor: Priovant Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07532603·Phase 2, Phase 3·Recruiting·Listed Apr 2026

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Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer

for Urothelial Cancer

Drug: PF-08634404

Sites in Nashville, Chattanooga +93 more locations

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07421700·Phase 1, Phase 2·Recruiting·Listed Feb 2026

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A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma

for Solid Tumors

Drug: INCB161734

Sites in Nashville +67 more locations

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT07522073·Phase 3·Recruiting·Listed Apr 2026

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A Trial to Investigate Safety, Exposure, and Efficacy of HU6 Compared With Placebo in Adult Participants With Metabolic Dysfunction-associated Steatohepatitis (MASH)

for MASH - Metabolic Dysfunction-Associated Steatohepatitis

Sites in Clarksville +30 more locations

Sponsor: Rivus Pharmaceuticals, Inc.

Sex: All·Age: 30+

Code: NCT07491458·Phase 2·Recruiting·Listed Mar 2026

Apply to this trial

A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)

for Macular Degeneration

Sites in Germantown +52 more locations

Sponsor: EyeBiotech Ltd.

Sex: All·Age: 50+

Code: NCT07440225·Phase 2, Phase 3·Recruiting·Listed Feb 2026

Apply to this trial

COMO: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME

for Diabetic Macular Edema

Drug: Aflibercept

Sites in Nashville +49 more locations

Sponsor: EyePoint Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT07449936·Phase 3·Recruiting·Listed Mar 2026

Apply to this trial

CAPRI: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME

for Diabetic Macular Edema

Drug: Aflibercept

Sites in Germantown +49 more locations

Sponsor: EyePoint Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT07449923·Phase 3·Recruiting·Listed Mar 2026

Apply to this trial

Efficacy and Safety of Oral KAI-7535 in Adult Participants Living With Obesity or Overweight With at Least 1 Weight-Related Comorbidity

for Obesity

Sites in Knoxville +30 more locations

Sponsor: Kailera

Sex: All·Age: 18 - 75

Code: NCT07497880·Phase 2·Recruiting·Listed Mar 2026

Apply to this trial

A Study of Nipocalimab in Adults With Moderate to Severe Systemic Lupus Erythematosus

for Lupus Erythematosus, Systemic

Drug: Nipocalimab

Sites in Jackson +33 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18 - 75

Code: NCT07438496·Phase 3·Recruiting·Listed Feb 2026

Apply to this trial

LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis

for Ulcerative Colitis (UC)

Drug: LY4268989

Sites in Jackson +49 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 80

Code: NCT07415044·Phase 2·Recruiting·Listed Feb 2026

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Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-related Macular Degeneration (AQUARIUS)

for Neovascular Age-Related Macular Degeneration (nAMD)

Drug: Ixo-vec

Sites in Nashville +78 more locations

Sponsor: Adverum Biotechnologies, Inc.

Sex: All·Age: 50+

Code: NCT07482176·Phase 3·Recruiting·Listed Mar 2026

Apply to this trial

Study to Evaluate the Safety and Efficacy of Larsucosterol in Participants With Alcohol-associated Hepatitis (AH)

for Hepatitis

Drug: Larsucosterol

Sites in Nashville, Chattanooga +82 more locations

Sponsor: Bausch Health Americas, Inc.

Sex: All·Age: 18+

Code: NCT07428538·Phase 3·Recruiting·Listed Feb 2026

Apply to this trial

A Study to Evaluate the Effectiveness of Two Doses of AP-472 as Adjunctive Therapy to Levodopa in Parkinson's Disease (PD) Participants With Motor Fluctuations

for Parkinson Disease

Sites in Nashville +29 more locations

Sponsor: Appello Pharmaceuticals, Inc.

Sex: All·Age: 30 - 80

Code: NCT07432958·Phase 2·Recruiting·Listed Feb 2026

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A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults

for Chronic Idiopathic Constipation (CIC)

Drug: Tenapanor

Sites in Nashville, Memphis +107 more locations

Sponsor: Ardelyx

Sex: All·Age: 18 - 80

Code: NCT07382167·Phase 3·Recruiting·Listed Feb 2026

Apply to this trial

A Study to Test Whether Different Doses of BI 3000202 Help People With Systemic Lupus Erythematosus (SLE)

for Systemic Lupus Erythematosus

Drug: BI 3000202

Sites in Memphis, Jackson +28 more locations

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18 - 74

Code: NCT07409181·Phase 2·Recruiting·Listed Feb 2026

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A Study to Assess the Effectiveness and Safety of IPN10200 Over Time in Adults With Moderate to Severe Wrinkle-like Lines Between the Eyebrows

for Moderate to Severe Glabellar Lines

Drug: IPN10200

Sites in Nashville +40 more locations

Sponsor: Ipsen

Sex: All·Age: 18 - 80

Code: NCT07435428·Phase 3·Recruiting·Listed Feb 2026

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A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)

for Non-small Cell Lung Cancer (NSCLC)

Drug: Durvalumab

Sites in Nashville +36 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07361497·Phase 3·Recruiting·Listed Jan 2026

Apply to this trial

A Phase 3 Trial to Compare IV BCV Versus IV CDV for Treatment of Adenovirus Infection After Allo-HCT

for Adenovirus Infections

Sites in Memphis +31 more locations

Sponsor: SymBio Pharmaceuticals

Sex: All·Age: 2 Months+

Code: NCT07387367·Phase 3·Recruiting·Listed Feb 2026

Apply to this trial

A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate to Severe Chronic Obstructive Pulmonary Disease

for Moderate to Severe Chronic Obstructive Pulmonary Disease

Drug: PF-07275315

Sites in Franklin, Hendersonville +55 more locations

Sponsor: Pfizer

Sex: All·Age: 35 - 80

Code: NCT07363694·Phase 2, Phase 3·Recruiting·Listed Jan 2026

Apply to this trial

A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes

for Obesity or Overweight

Drug: Enicepatide

Sites in Nashville, Clarksville +34 more locations

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT07351045·Phase 3·Recruiting·Listed Jan 2026

Apply to this trial

PODOMOUNT-Basket, a Study to Test Whether BI 764198 Helps Adults and Adolescents With Different Types of Kidney Disease

for Proteinuric Kidney Diseases

Sites in Chattanooga +24 more locations

Sponsor: Boehringer Ingelheim

Sex: All·Age: 12+

Code: NCT07355296·Phase 2·Recruiting·Listed Jan 2026

Apply to this trial

A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes

for Obesity

Drug: Eloralintide

Sites in Nashville +40 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07321886·Phase 3·Recruiting·Listed Jan 2026

Apply to this trial

Effectiveness and Adverse-effect Switch Evaluation of Xanomeline and Trospium Chloride (KarXT)

for Schizophrenia

Drug: KarXT

Sites in Franklin, Cordova +50 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07379827·Recruiting·Listed Feb 2026

Apply to this trial

A Study to Test Whether BI 3802876 is Tolerated in People With Compensated Liver Cirrhosis Due to Metabolic Dysfunction- Associated Steatohepatitis (MASH)

for Liver Cirrhosis

Drug: BI 3802876

Sites in Nashville +25 more locations

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18 - 75

Code: NCT07325526·Phase 2·Recruiting·Listed Jan 2026

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A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer

for CRC (Colorectal Cancer)

Drug: Bevacizumab

Sites in Knoxville +69 more locations

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT07284849·Phase 3·Recruiting·Listed Dec 2025

Apply to this trial

Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

for Advanced Non-Small Cell Lung Cancer

Drug: PF-08634404

Sites in Nashville, Knoxville +191 more locations

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07222566·Phase 3·Recruiting·Listed Oct 2025

Apply to this trial

A Study to Learn About a Clostridioides Difficile Vaccine in People 65 Years of Age and Older

for Clostridioides Difficile Associated Disease

Sites in Nashville, Memphis +133 more locations

Sponsor: Pfizer

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT07282665·Phase 3·Recruiting·Listed Dec 2025

Apply to this trial

A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer

for Breast Neoplasms

Sites in Nashville +27 more locations

Sponsor: Eli Lilly and Company

Sex: Female·Age: 18+

Code: NCT07287098·Phase 2·Recruiting·Listed Dec 2025

Apply to this trial

Common conditions studied in Tennessee

Breast Cancer (51 active studies)
Colorectal Cancer (33 active studies)
Advanced Solid Tumor (31 active studies)
Ovarian Cancer (31 active studies)
Cancer (28 active studies)
Obesity (28 active studies)

Leading research sponsors in Tennessee

Vanderbilt University Medical Center
St. Jude Children's Research Hospital
AstraZeneca
National Cancer Institute (NCI)
Merck Sharp & Dohme LLC

Frequently asked questions

How many paid clinical trials are currently recruiting in Tennessee?

There are approximately 2,077 recruiting clinical trials in Tennessee listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.

Do clinical trials in Tennessee pay participants?

Most recruiting trials in Tennessee compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.

Who can participate in a clinical trial in Tennessee?

Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.

What conditions are most commonly studied in Tennessee?

The most common conditions under active study in Tennessee include Breast Cancer (51), Colorectal Cancer (33), Advanced Solid Tumor (31), Ovarian Cancer (31), among many others. Browse the list above to explore every recruiting trial.

Are there clinical trials for healthy volunteers in Tennessee?

Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Tennessee on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.

How do I enroll in a clinical trial in Tennessee?

Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.

Browse more clinical trials

All cities in Tennessee

Related healthcare resources in Tennessee

Behavioral health news in Tennessee Latest Tennessee clinical trials research report

Trials by condition in Tennessee

Breast Cancer· 51 Colorectal Cancer· 33 Ovarian Cancer· 31 Obesity· 28 Prostate Cancer· 27