Endocannabinoids in Reward

Part of paid clinical trials in Charleston, South Carolina.

Sponsor
Medical University of South Carolina
Study ID
NCT07815691
Phase
PHASE2
Status
Not Yet Recruiting

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Conditions

  • Cannabis Use Disorder

Eligibility Criteria

Sex
ALL
Age
21 Years - 45 Years
Healthy Volunteers
Not accepted

Interventions

  • Dronabinol — DRUG
    Oral dronabinol capsules (40 mg)
  • Placebo — DRUG
    Matched placebo capsules

Study Details

This study will examine sex differences in the effects of cannabis in people that regularly use it. Men and women that use cannabis at least 4 days a week will participate in a study involving 3 in-person visits. The first visit will be used to determine eligibility for the study. The other two visits will last 7 hours each and take place at least two days apart. Visits include administration of either THC, the chemical responsible for many of the psychoactive effects of cannabis, or a placebo; completion of questionnaires; and a 1-hour brain scan. One visit will also include a blood draw for genetic testing.

Key Dates

First listed
Sep 11, 2026
Start date
Sep 15, 2026
Status verified
Sep 2026
Primary completion
Jul 31, 2031
Completion
Jul 31, 2031

Study Design

Enrollment
78 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Other: Males
  • Other: Females

Primary Outcome Measure

Nucleus accumbens glutamate [ Time Frame: 2 hours post-dose ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Medical University of South CarolinaCharlestonSouth Carolina29403
Erin Martin, Ph.D.
[email protected]
843-876-3528

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By research site
Medical University of South Carolina· Charleston, SC

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