Improving TelePrEP Initiation and Retention Outcomes in the US: The MISTR+ Study

Part of paid clinical trials in Atlanta, Georgia.

Sponsor: Emory University
Study ID: NCT07821671
Status: Not Yet Recruiting

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Conditions

Human Immunodeficiency Virus

Eligibility Criteria

Sex: ALL
Age: 18 Years - N/A
Healthy Volunteers: Not accepted

Interventions

No Marginal Cost Interventions — BEHAVIORAL
The exact intervention types will be determined based on Aim 1 data analyses that seek to identify the areas that could most benefit from intervention. Possible interventions to be tested include message content, message format, message time of day, and website design.
Low-Marginal Cost Interventions — BEHAVIORAL
The exact intervention types will be determined based on Aim 1 data analyses that seek to identify the areas that could most benefit from intervention. Possible interventions to be tested include warm handoffs, personalized messages, and enhanced remote laboratory testing.
Standard of Care — BEHAVIORAL
MISTR users receive the current standard of care. The standard of care will be updated as impactful interventions are identified.

Study Details

This study uses a rapid randomized controlled trial (RCT) design to examine HIV pre-exposure prophylaxis (PrEP) delivered through telehealth. This study will develop a knowledge base of small, effective changes to digital messaging and website design to improve telemedicine PrEP (telePrEP) provision for MISTR users in the United States.

Key Dates

First listed: Sep 16, 2026
Start date: Mar 1, 2027
Status verified: Sep 2026
Primary completion: May 31, 2031
Completion: May 31, 2031

Study Design

Enrollment: 223,165 participants (estimated)
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Arms

Experimental: Intervention Condition
Individuals using MISTR services receiving an intervention condition.
Active Comparator: Control Condition
Individuals using MISTR services receiving the standard of care.