An Open-Label Trial of Veligrotug in Participants With Thyroid Eye Disease Who Previously Responded to Teprotumumab

Part of paid clinical trials in Newport Beach, California.

Sponsor
Viridian Therapeutics, Inc.
Study ID
NCT07832136
Phase
PHASE4
Status
Not Yet Recruiting

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Conditions

  • Thyroid Eye Disease

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • veligrotrug (LUMVOA™) — DRUG
    intravenous infusions

Study Details

This is a clinical trial to evaluate the safety and efficacy of veligrotug (LUMVOA™) in participants with moderate to severe TED who previously received and responded to an initial course of teprotumumab treatment but subsequently had a disease recurrence.

Key Dates

First listed
Sep 21, 2026
Start date
Sep 30, 2026
Status verified
Sep 2026
Primary completion
Apr 30, 2027
Completion
Sep 30, 2027

Study Design

Enrollment
30 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: 5 IV infusions of 10 mg/kg of veligrotug
    Participants will receive veligrotug10 mg/kg as an intravenous (IV) infusion every 3 weeks (Q3W) for 12 weeks.

Primary Outcome Measure

Safety and tolerability of veligrotrug (LUMVOA™) [ Time Frame: Through Week 15 ]

Central Contacts

Locations (8)

FacilityCityStateZIPSite coordinators
Office of Dr. Amy Patel Jain, MDNewport BeachCalifornia92660
Study Coordinator
[email protected]
248-800-1180
Sarasota Retina InstituteSarasotaFlorida34239
Study Coordinator
[email protected]
941-921-5335
Ophthalmic Consultants of BostonEast WeymouthMassachusetts02189
Study Coordinator
[email protected]
617-314-2732
Kahana Oculoplastic & Orbital SurgeryLivoniaMichigan48152
Study Coordinator
[email protected]
248-800-1180
University HealthKansas CityMissouri64108
Study Coordinator
[email protected]
816-218-2582
The Center for Eye and Facial Plastic SurgerySomersetNew Jersey08873
Study Coordinator
[email protected]
609-798-7171
Baylor College of Medicine Alkek Eye CenterHoustonTexas77030
Study Coordinator
[email protected]
941-921-5335
Neuro-Eye Clinical TrialsHoustonTexas34239
Study Coordinator
[email protected]
713-942-2187

Find similar trials in Newport Beach, CA

By research site
Office of Dr. Amy Patel Jain, MD· Newport Beach, CASarasota Retina Institute· Sarasota, FLOphthalmic Consultants of Boston· East Weymouth, MAKahana Oculoplastic & Orbital Surgery· Livonia, MIUniversity Health· Kansas City, MOThe Center for Eye and Facial Plastic Surgery· Somerset, NJ

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