Beta-2 Adrenergic Receptor Polymorphic Variants: An Endotype of Salt Sensitive Hypertension (Beta2AR).

Conditions

• Genetics in Hypertension

Eligibility Criteria

Sex

ALL

Age

18 Years - 50 Years

Healthy Volunteers

Not accepted

Interventions

• low sodium diet — OTHER
  Low Sodium Diet
• high sodium diet — OTHER
  High Sodium Diet
• renal plasma flow — PROCEDURE
  renal blood flow response to diet and angiotensin II by diplotype
• SIEA collection — PROCEDURE
  Vasoreactivity response by diplotype

Study Details

All living things are made of building blocks called cells. Genes are the part of cells that contain the instructions which determine important things about you, like your height or hair color, and affect your health. DNA is the material in the cells that makes up your genes and your particular make-up is call your genotype. Changes or differences in a gene (your genotype) may affect your chances of developing a particular disease, or how a person responds to a particular drug. Your genes are passed down from your parents and then passed on to your children. Different forms of certain genes in your body, for example, the B2AR gene, can increase your blood pressure. The form of the gene that could raise your blood pressure is called the risk allele or risk genotype. Taking too much salt in your food or drink also can increase your blood pressure. In this research study we want to determine if different forms of the B2AR gene and the level of salt intake act together to cause high blood pressure.

Key Dates

First listed

Sep 22, 2026

Start date

Nov 30, 2026

Status verified

Sep 2026

Primary completion

Apr 30, 2030

Completion

Apr 30, 2030

Study Design

Enrollment

110 participants (estimated)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: Low Salt
  Low Salt Diet
• Experimental: High Salt
  High Salt Diet

Primary Outcome Measure

Differences in systolic SSBP between the diplotypes [ Time Frame: Two weeks ]

Central Contacts

• Rayan Uddin, BS
  617-732-4248
  [email protected]
• Kristen Foote, MBA
  617-525-9585
  [email protected]

Locations (1)

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