Lower Body Negative Pressure to Validate Physiological Monitors

Conditions

• Physiological Stress

Eligibility Criteria

Sex

ALL

Age

18 Years - 55 Years

Healthy Volunteers

Accepted

Interventions

• Lower Body Negative Pressure with Noninvasive Physiological Monitoring — DIAGNOSTIC_TEST
  Participants will undergo a graded lower body negative pressure protocol using suction levels of 15, 30, 45, 60, 70, 80, 90, and 100 mmHg, each for up to 5 minutes or until presyncopal symptoms or other termination criteria occur. During the procedure, validated reference physiological measurements and investigational noninvasive monitor signals will be collected simultaneously.

Study Details

The purpose of this research is to test the accuracy of non-invasive physiological monitors while the body responds to different levels of lower body negative pressure (LBNP).

Key Dates

First listed

Sep 24, 2026

Start date

Sep 30, 2026

Status verified

Sep 2026

Primary completion

Sep 28, 2028

Completion

Sep 28, 2028

Study Design

Enrollment

50 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: Healthy Volunteers Undergoing Lower Body Negative Pressure
  Healthy adult participants will complete one study visit involving graded lower body negative pressure while standard physiological reference measurements and noninvasive investigational physiological monitor data are collected.

Primary Outcome Measure

Arterial Oxygen Saturation During Lower Body Negative Pressure [ Time Frame: During the single study visit, from baseline through completion of the lower body negative pressure protocol, up to 40 minutes ]

Central Contacts

• Pamela Engrav
  507-255-6938
  [email protected]
• Ronee Harvey
  507-255-1466
  [email protected]

Locations (1)

Find similar trials in Rochester, MN

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