MINTER Trial: Metal Intervention aNd ThErapy With Radiotherapy In Thoracic Cancer Using Copper Donor Therapy: A Phase 2, Open-Label Study

Part of paid clinical trials in Houston, Texas.

Sponsor
M.D. Anderson Cancer Center
Study ID
NCT07843537
Phase
PHASE2
Status
Not Yet Recruiting

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Conditions

  • Thoracic Cancer

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Disulfiram 250 mg — DRUG
    Given orally once daily
  • Copper Gluconate 2 mg — DRUG
    Given orally three times daily
  • Radiation Therapy — DRUG
    Delivered per institutional standards (radiotherapy alone in 10-15 fractions as local consolidation therapy).

Study Details

This study is being done to test whether adding two drugs-disulfiram and copper gluconate-to radiation therapy can help overcome this resistance and improve treatment outcomes. When disulfiram is combined with copper, it forms a substance that may increase stress within cancer cells and lead to a specific type of cancer cell death knowns as "cuproptosis".

Key Dates

First listed
Sep 28, 2026
Start date
Mar 1, 2027
Status verified
Sep 2026
Primary completion
Mar 30, 2030
Completion
Mar 30, 2032

Study Design

Enrollment
30 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Treatment with Disulfiram + Copper Gluconate + Concurrent LCT

Primary Outcome Measure

Safety and Adverse Events (AEs) [ Time Frame: Through study completion; an average of 1 year ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UT MD AndersonHoustonTexas77030
Steven Lin, MD, PHD
[email protected]
713-563-8490
Steven Lin, MD, PHD (PRINCIPAL_INVESTIGATOR)

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By research site
UT MD Anderson· Houston, TX

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