Circadian Variation of Anti-Factor Xa in Hospitalized Trauma Patients

Conditions

• Circadian Variation in Anti-Factor Xa (Anti-FXa) Activity

Eligibility Criteria

Sex

ALL

Age

18 Years - 80 Years

Healthy Volunteers

Not accepted

Study Details

The purpose of this study is to determine whether a circadian rhythm exists in anti-FXa levels and AT3 activity in hospitalized trauma patients receiving low-molecular-weight heparin (LMWH) chemoprophylaxis

Key Dates

First listed

Oct 2, 2026

Start date

Aug 26, 2026

Status verified

Sep 2026

Primary completion

Aug 26, 2027

Completion

Mar 26, 2028

Study Design

Enrollment

40 participants (estimated)

Arms

• Arm: Hospitalized Trauma Patients Receiving LMWH Chemoprophylaxis
  Hospitalized trauma patients receiving low-molecular-weight heparin (LMWH) chemoprophylaxis as part of routine clinical care. Participants will have anti-FXa levels and antithrombin III (AT3) activity measured at predefined time points to evaluate potential circadian variation in these measures.

Primary Outcome Measure

Change in anti-factor Xa (anti-FXa) levels [ Time Frame: 4 hours after the 3rd LMWH dose (T0), then every 6 hours (T6, T12, T18) ]

Central Contacts

• Evaline W Kihara, MSN, APRN, AGACNP-BC, CCRN
  (713) 500-6362
  [email protected]
• Nikhil Padhye, PhD
  (713) 500-2035
  [email protected]

Locations (1)

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