A Study to Learn About the Study Medicine Called Tilrekimig ( PF-07275315) in People With Severe Asthma

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
Pfizer
Study ID
NCT07869043
Phase
PHASE3
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
12 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • tilrekimig — DRUG
    subcutaneous injection
  • Placebo — OTHER
    subcutaneous injection

Study Details

The purpose of this clinical study is to learn about the safety and effects of the study medicine (called tilrekimig) for the potential treatment of severe asthma. Asthma is a condition that makes it challenging to breathe, which negatively impacts the quality of life of people who are affected. The study is seeking participants who: * Have a history of severe asthma for at least 12 months * Have had at least 2 asthma attacks (also known as exacerbations) within the last 12 months All participants will be given shots of study medicine or a placebo at the study clinic. Tilrekimig or the placebo will be given about every 4 weeks during the study. The study will compare the experiences of people receiving tilrekimig to those people who receive the placebo. This will help determine if tilrekimig is safe and effective.

Key Dates

First listed
Oct 9, 2026
Start date
Sep 30, 2026
Status verified
Oct 2026
Primary completion
Jun 7, 2029
Completion
Aug 30, 2029

Study Design

Enrollment
1,100 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Treatment Arm A Tilrekimig
    Tilrekimig
  • Placebo Comparator: Treatment Arm B Placebo
    Placebo

Primary Outcome Measure

Annualized asthma exacerbation rate over 52 weeks [ Time Frame: Baseline through Week 52 ]

Central Contacts

Locations (3)

FacilityCityStateZIPSite coordinators
Allergy and Clinical Immunology AssociatesPittsburghPennsylvania15241-
Orion Clinical ResearchAustinTexas78759-
DM Clinical ResearchTomballTexas77375-

Find similar trials in Pittsburgh, PA

Nationwide
Asthma trialsPulmonology trialsLung disease trials
By condition
Asthma
By specialty
PulmonologyLung disease
By research site
Allergy and Clinical Immunology Associates· Pittsburgh, PAOrion Clinical Research· Austin, TXDM Clinical Research· Tomball, TX

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