Post-exercise Blood Pressure With Inorganic Nitrate

Conditions

• Central Adiposity
• Obese Individuals

Eligibility Criteria

Sex

ALL

Age

18 Years - 40 Years

Healthy Volunteers

Accepted

Interventions

• Beetroot Juice - Active + Exercise — DIETARY_SUPPLEMENT
  Supplement with 140 mL nitrate-rich beverage (800mg NO3-) (\~12.9 mmol/L) 1 hour 30 minutes before lab visit after a 3-day washout + ACUTE EXERCISE and post-exercise blood pressure, and central hemodynamics measured via impedance cardiography.
• Beetroot juice placebo + Exercise — DIETARY_SUPPLEMENT
  Supplement with 140 mL nitrate-depleted beverage (\<0.1 mmol/L) after a 3-day washout + ACUTE EXERCISE, and post-exercise blood pressure, and central hemodynamics measured via impedance cardiography
• Beetroot Juice - Active + No exercise — DIETARY_SUPPLEMENT
  Supplement with 140mL nitrate rich beverage (800mg NO3-) (\~12.9 mmol/L) 1 hour 30 minutes before lab visit after a 3 day washout + NO EXERCISE, and blood pressure, and central hemodynamics measured via impedance cardiography.
• Beetroot juice placebo+ No exercise — DIETARY_SUPPLEMENT
  Supplement with 140 mL nitrate-depleted beverage (\<0.1 mmol/L) after a 3-day washout + NO EXERCISE, and blood pressure and central hemodynamics measured via impedance cardiography.

Study Details

This study is examining whether acute inorganic nitrate supplementation in the form of beetroot juice, paired with an acute bout of exercise, affects blood pressure and what is the magnitude of the difference compared to exercise alone.

Key Dates

First listed

Oct 9, 2026

Start date

Oct 15, 2026

Status verified

Oct 2026

Primary completion

Jan 1, 2027

Completion

Mar 30, 2027

Study Design

Enrollment

12 participants (estimated)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

OTHER

Arms

• Experimental: A
  1 x 4 crossover design where each participant will be randomized to complete four conditions after at least a 3-day washout period.
• Active Comparator: B
  1 x 4 crossover design where each participant will be randomized to complete four conditions after at least a 3-day washout period.
• Placebo Comparator: C
  1 x 4 crossover design where each participant will be randomized to complete four conditions after at least a 3-day washout period.
• Sham Comparator: D
  1 x 4 crossover design where each participant will be randomized to complete four conditions after at least a 3-day washout period.

Primary Outcome Measure

Blood pressure (Central and Peripheral) [ Time Frame: Before each condition and after every 15 minutes for 3 hours. ]

Central Contacts

• Money Ghimire, M.S
  4349243004
  [email protected]

Locations (1)

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