Effects of Cannabidiol (CBD) on a Fixed Dose of Delta-9-tetrahydrocannabinol (THC)

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
Johns Hopkins University
Study ID
NCT07870187
Phase
PHASE1
Status
Not Yet Recruiting

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Conditions

  • Cannabis Intoxication

Eligibility Criteria

Sex
ALL
Age
21 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • 0mg THC + 0mg CBD Brownie — DRUG
    Brownie containing no THC and CBD will be self administered through oral ingestion.
  • 10mg THC + 0mg CBD Brownie — DRUG
    Brownie containing 10mg THC and no CBD will be self administered through oral ingestion.
  • 10mg THC + 10mg CBD Brownie — DRUG
    Brownie containing 10mg THC and 10mg CBD will be self administered through oral ingestion.
  • 10mg THC + 50mg CBD Brownie — DRUG
    Brownie containing 10mg THC and 50mg CBD will be self administered through oral ingestion.
  • 10mg THC + 100mg CBD Brownie — DRUG
    Brownie containing 10mg THC and 100mg CBD will be self administered through oral ingestion.
  • 10mg THC + 300mg CBD Brownie — DRUG
    Brownie containing 10mg THC and 300mg CBD will be self administered through oral ingestion.
  • 0mg THC + 300mg CBD Brownie — DRUG
    Brownie containing no THC and 300mg CBD will be self administered through oral ingestion.

Study Details

This study will evaluate the subjective and behavioral effects of cannabis products containing delta-9-tetrahydrocannabinol and cannabidiol

Key Dates

First listed
Oct 13, 2026
Start date
Feb 1, 2027
Status verified
Oct 2026
Primary completion
Feb 1, 2029
Completion
Feb 1, 2029

Study Design

Enrollment
70 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Placebo Comparator: 0mg THC + 0mg CBD
    Participants ingest a brownie containing 0mg THC and 0mg CBD.
  • Experimental: 10mg THC + 0mg CBD
    Participants ingest a brownie containing 10mg THC and 0mg CBD.
  • Experimental: 10mg THC + 10mg CBD
    Participants ingest a brownie containing 10mg THC and 10mg CBD.
  • Experimental: 10mg THC + 50mg CBD
    Participants ingest a brownie containing 10mg THC and 50mg CBD.
  • Experimental: 10mg THC + 100mg CBD
    Participants ingest a brownie containing 10mg THC and 100mg CBD.
  • Experimental: 10mg THC + 300mg CBD
    Participants ingest a brownie containing 10mg THC and 300mg CBD.
  • Experimental: 0mg THC + 300mg CBD
    Participants ingest a brownie containing 0mg THC and 300mg CBD.

Primary Outcome Measure

Driving performance as assessed by standard deviation of lateral position (SDLP) [ Time Frame: Baseline, , 2-, 4-, 6-, 8-hours post dosing. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Johns Hopkins UniversityBaltimoreMaryland21224
Carlos A Zamarripa, PhD
[email protected]
410-550-6969

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