Exercise Training Intensity and Nitrate Supplementation in Post-Menopausal Females on Hormone Therapy

Part of paid clinical trials in Charlottesville, Virginia.

Sponsor
University of Virginia
Study ID
NCT07871396
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
FEMALE
Age
45 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Moderate Intensity Exercise (MIE) — OTHER
    MIE bout of exercise will be completed after 3 days of supplementation with BRJ/placebo. This intensity will be equivalent to the watts at lactate threshold.
  • High intensity exercise (HIE) — OTHER
    HIE bout of exercise will be completed after 3 days of supplementation with BRJ/placebo. This intensity will be equivalent to the watts at Lactate threshold + 75% ∆ (VO2peak - LT).
  • Control (No exercise) — OTHER
    The control session will involve passive rest.

Study Details

This study is examining whether short-term supplementation with inorganic nitrate in the form of beetroot juice can enhance vascular function in postmenopausal females taking hormone therapy compared to placebo.

Key Dates

First listed
Oct 13, 2026
Start date
Oct 15, 2026
Status verified
Sep 2026
Primary completion
Nov 30, 2027
Completion
Jan 30, 2028

Study Design

Enrollment
24 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • Experimental: Beetroot juice
    Participants will supplement with nitrate-rich beetroot juice (BRJ) for 3 days: 6.45 mmol of NO3 in the morning and 6.45 mmol in the evening for 2 days, and 12.9 mmol 2 hours before the lab visit.
  • Placebo Comparator: Placebo
    Participants will supplement with nitrate-depleted beetroot juice (BRJ) for 3 days: 6.45 mmol of NO3 in the morning and 6.45 mmol in the evening for 2 days, and 12.9 mmol 2 hours before the lab visit.

Primary Outcome Measure

Vascular Endothelial Function (Flow-Mediated Dilation [FMD]) [ Time Frame: At baseline on each condition and following 3-day supplementation before and after exercise/rest conditions up to 3 hours post (60, 90, 120, 150, and 180 min post) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of VirginiaCharlottesvilleVirginia22903
Money Ghimire Ghimire, M.S.
[email protected]
4349243004

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By condition
Menopause
By specialty
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By research site
University of Virginia· Charlottesville, VA

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