Cognitive Neurocomputational Task Reliability and Clinical Applications Consortium: Study 2

Conditions

• Healthy Adult
• SCHIZOPHRENIA 1 (Disorder)
• Schizo Affective Disorder

Eligibility Criteria

Sex

ALL

Age

18 Years - 59 Years

Healthy Volunteers

Accepted

Interventions

• Motion Perception Task — BEHAVIORAL
  Assesses updating of beliefs from new sensory inputs with prior knowledge via perceiving direction changes in random dot motion stimuli
• Sine Wave Speech Task — BEHAVIORAL
  Measures the degree to which overweighting of prior beliefs impacts processing of sensory inputs (detection of speech).
• Volatility Task — BEHAVIORAL
  Measures the updating of priors about the location of a bag drop from a helicopter when the location changes (prediction errors).
• Choice Probabilistic Reversal Task — BEHAVIORAL
  Assesses prior belief updating when feedback about obtaining positive outcomes changes (prediction errors).
• Kamin Blocking Task — BEHAVIORAL
  Examines the role of mismatches between learned priors and new information (prediction errors) in belief formation about event causes.
• Minnesota Trust Game — BEHAVIORAL
  Assesses the degree to which people distinguish between their priors about others' motivations, such as selfishness and spite, and impersonal chance in one-shot trust game and dictator games.
• Dynamic Trust Game — BEHAVIORAL
  Assesses degree to which people learn and update priors about trusting partners from dynamic social feedback (prediction error) in a social exchange game.

Study Details

In Study 2, investigators will recruit individuals with schizophrenia (SZ) and or schizoaffective disorder (SZA) and healthy controls (HC) using optimized behavioral tasks to replicate the behavioral findings from Study 1 and to assess additional psychometric properties such as test re-test reliability and practice effects. Investigators will obtain data on: A) clinical symptoms, with detailed assessment of hallucinations and delusions; B) community functioning; and C) functional capacity, allowing us to examine clinical validity. To generate a sample with sufficient variation in hallucinations and delusions, investigators will recruit the following groups that balance feasibility with clinical relevance: A) healthy controls \[HC, N=125\]; B) schizophrenia and schizoaffective disorder \[SZ/SZA, N=200\]). Investigators anticipate a \~20% screen fail/drop-out rate based upon prior studies. Thus, investigators will run an additional 40 SZ/SZA and 15 HC. Investigators will administer tasks optimized in Aim 1 without electroencephalogram (EEG), to this new sample of individuals with SZ/SZA and HC. All participants will be retested after approximately 28 days and repeat clinical assessments. Although the investigators' goal is to shorten task length using the Study 1 analyses, they will administer longer tasks than optimal for public dissemination in Study 2 to determine the minimum number of trials required for acceptable reliability. Study 2 will use the same clinical and functional measures as Study 1.

Key Dates

First listed

Oct 15, 2026

Start date

Apr 30, 2028

Status verified

Oct 2026

Primary completion

Jun 30, 2031

Completion

Jun 30, 2031

Study Design

Enrollment

325 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Primary Outcome Measure

Motion Perception Task Performance [ Time Frame: 1 hour ]

Central Contacts

• Deanna Barch, Ph.D.
  314-935-8729
  [email protected]
• Lori Ingram
  314-747-2160
  [email protected]

Locations (5)

Find similar trials in Irvine, CA

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