Harvard/ Massachusetts Eye & Ear

Clinical research site in Boston, Massachusetts · 243 CHARLES ST, BOSTON, MA 02114-3002 · (617) 573-3532 · Website

As of July 2026, 31 paid clinical trials are recruiting at Harvard/ Massachusetts Eye & Ear in Boston, Massachusetts. Active studies at this site cover conditions such as Cone Rod Dystrophy, Glaucoma and Juvenile Macular Degeneration. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 19, 2026.

Recruiting clinical trials at Harvard/ Massachusetts Eye & Ear (31)

A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy

for Age-related Macular Degeneration (AMD)

140 locations incl. Chandler

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 50 - 85

Code: NCT06541704·Phase 3·Recruiting·Listed Aug 2024

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Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD

for AMD

65 locations incl. Phoenix

Sponsor: AbbVie

Sex: All·Age: 50 - 89

Code: NCT05407636·Phase 3·Recruiting·Listed Jun 2022

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A Phase 3 Randomized, Masked, Controlled Trial to Evaluate Efficacy and Safety of Belzupacap Sarotalocan (AU-011) Treatment Compared to Sham Control in Subjects With Primary Indeterminate Lesions or Small Choroidal Melanoma

for Choroidal Melanoma

34 locations incl. La Jolla

Sponsor: Aura Biosciences

Sex: All·Age: 18+

Code: NCT06007690·Phase 3·Recruiting·Listed Aug 2023

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An Efficacy and Safety Study of Cenegermin Ophthalmic Solution Compared With Vehicle in the Treatment of PCED

for Persistent Corneal Epithelial Defect

18 locations incl. Huntington Beach

Sponsor: Dompé Farmaceutici S.p.A

Sex: All·Age: 18+

Code: NCT07519902·Phase 3·Recruiting·Listed Apr 2026

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Phase 4 Study: Long-term Safety and Efficacy of NT-501 in MacTel Type 2, Including Sham Procedure Participants

for Macular Telangiectasia Type 2 (MacTel)

23 locations incl. La Jolla

Sponsor: Neurotech Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06971939·Phase 4·Recruiting·Listed May 2025

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A Study of AMG 732 in Healthy Participants and Participants With Thyroid Eye Disease

for Thyroid Eye Disease

12 locations incl. Little Rock

Sponsor: Amgen

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06401044·Phase 1, Phase 2·Recruiting·Listed May 2024

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Suprachoroidal Administration in Subjects With Metastases to the Choroid

for Eye Cancer

10 locations incl. Palo Alto

Sponsor: Aura Biosciences

Sex: All·Age: 18+

Code: NCT06643884·Phase 2·Recruiting·Listed Oct 2024

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Study to Evaluate ACDN-01 in ABCA4-related Stargardt Retinopathy (STELLAR)

for Stargardt Disease

10 locations incl. San Francisco

Sponsor: Ascidian Therapeutics, Inc

Sex: All·Age: 12+

Code: NCT06467344·Phase 1, Phase 2·Recruiting·Listed Jun 2024

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An Observational Study in Subjects to Follow the Progression of Stargardt Disease Type 1 (STGD1) Caused by Bi-Allelic Autosomal Recessive Mutations in the ABCA4 Gene

for Stargardt

14 locations incl. San Diego

Sponsor: Splice Bio

Sex: All·Age: 12 - 65

Code: NCT06435000·Recruiting·Listed May 2024

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A Study of the Safety and Tolerability of ASP7317 in Senior Adults Who Are Losing Their Clear, Sharp Central Vision Due to Geographic Atrophy Secondary to Dry Age-related Macular Degeneration

for Age-Related Macular Degeneration

12 locations incl. Los Angeles

Sponsor: Astellas Institute for Regenerative Medicine

Sex: All·Age: 50+

Code: NCT03178149·Phase 1·Recruiting·Listed Jun 2017

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A Study to Investigate the Safety of DSP-3077 After a Unilateral Eye Injection in Male and Female Participants 18 Years of Age or Older With Retinitis Pigmentosa

for Retinitis Pigmentosa

2 locations incl. Boston

Sponsor: Sumitomo Pharma America, Inc.

Sex: All·Age: 18+

Code: NCT06891885·Phase 1, Phase 2·Recruiting·Listed Mar 2025

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Prescreening Study to Identify Potential Stargardt Participants for ACDN-01 Clinical Trials (STARPATH)

for Stargardt Disease

8 locations incl. San Francisco

Sponsor: Ascidian Therapeutics, Inc

Sex: All·Age: 5+

Code: NCT06445322·Recruiting·Listed Jun 2024

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A Phase 1/2, First-in-Human Dose Escalation/Expansion Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of a Subretinal Injection of SB-007 in Subjects With Stargardt Disease (STGD1)

for Stargardt Disease

5 locations incl. Aurora

Sponsor: Splice Bio

Sex: All·Age: 12 - 65

Code: NCT06942572·Phase 1, Phase 2·Recruiting·Listed Apr 2025

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Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants

for Inherited Retinal Degeneration

19 locations incl. Little Rock

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 4+

Code: NCT05589714·Recruiting·Listed Oct 2022

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Glaucoma Drainage Device and Endothelial Cell Loss Compare Trial

for Glaucoma

7 locations incl. San Francisco

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05924477·Recruiting·Listed Jun 2023

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Dropless Pars Plana Vitrectomy Study

for Rhegmatogenous Retinal Detachment

1 location in Boston

Sponsor: Massachusetts Eye and Ear Infirmary

Sex: All·Age: 40+·Accepts healthy volunteers

Code: NCT05331664·Phase 4·Recruiting·Listed Apr 2022

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Testing Effectiveness of a Stochastic Noise Stimulator to Immediately Improve Balance and Gait

for Vestibular Disorder

2 locations incl. Baltimore

Sponsor: Massachusetts Eye and Ear Infirmary

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT06688578·Recruiting·Listed Nov 2024

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ExCrossV Multi Site Trial for Vascularized High Risk Keratoplasty

for Corneal Transplant Failure

12 locations incl. Irvine

Sponsor: Massachusetts Eye and Ear Infirmary

Sex: All·Age: 18+

Code: NCT06753916·Phase 2·Recruiting·Listed Dec 2024

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ctDNA in Cutaneous Squamous Cell Carcinoma

for Cutaneous Squamous Cell Carcinoma

1 location in Boston

Sponsor: Massachusetts Eye and Ear Infirmary

Sex: All·Age: 18+

Code: NCT06875609·Recruiting·Listed Mar 2025

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A Trial of Hydrus Microstent Versus Goniotomy

for Glaucoma

1 location in Boston

Sponsor: Massachusetts Eye and Ear Infirmary

Sex: All·Age: 40 - 85

Code: NCT06289491·Recruiting·Listed Mar 2024

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Dark Adaptation as an Early Indicator of Response to Statin Therapy for Intermediate AMD

for Age-related Macular Degeneration

1 location in Boston

Sponsor: Massachusetts Eye and Ear Infirmary

Sex: All·Age: 50 - 85

Code: NCT04735263·Phase 2·Recruiting·Listed Feb 2021

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Brain Networks in Dystonia

for Spasmodic Dysphonia

1 location in Boston

Sponsor: Massachusetts Eye and Ear Infirmary

Sex: All·Age: 21 - 80·Accepts healthy volunteers

Code: NCT03042962·Recruiting·Listed Feb 2017

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Imaging Genetics of Laryngeal Dystonia

for Laryngeal Dystonia

1 location in Boston

Sponsor: Kristina Simonyan

Sex: All·Age: All ages

Code: NCT03042975·Recruiting·Listed Feb 2017

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An fMRI Investigation of the Effects of IV Lidocaine on Tinnitus

for Tinnitus

1 location in Boston

Sponsor: D. Bradley Welling, MD, PhD

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04192773·EARLY_Phase 1·Recruiting·Listed Dec 2019

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Brain-Computer Interfaces in Laryngeal Dystonia

for Laryngeal Dystonia

1 location in Boston

Sponsor: Kristina Simonyan

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT04421365·Recruiting·Listed Jun 2020

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Characterization of Clinical Phenotypes of Laryngeal Dystonia and Voice Tremor

for Laryngeal Dystonia

1 location in Boston

Sponsor: Massachusetts Eye and Ear Infirmary

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT05150106·Recruiting·Listed Dec 2021

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Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia

for Dystonia

1 location in Boston

Sponsor: Massachusetts Eye and Ear Infirmary

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT05317390·Recruiting·Listed Apr 2022

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Efgartigimod for the Treatment of Acute Optic Neuritis

for Optic Neuritis

2 locations in Boston

Sponsor: Anastasia Vishnevetsky, MD, MPH

Sex: All·Age: 18+

Code: NCT06453694·Phase 2·Recruiting·Listed Jun 2024

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Clarifying the Optimal Application of SLT Therapy Trial

for Glaucoma and Ocular Hypertension

27 locations incl. Laguna Hills

Sponsor: University of Pittsburgh

Sex: All·Age: 18+

Code: NCT04967989·Phase 3·Recruiting·Listed Jul 2021

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Measurable Residual Disease Detection Using Tumor-Informed ctDNA Surveillance After Curative-Intent Treatment in HPV-Independent Squamous Cell Carcinoma of the Head and Neck

for Squamous Cell Carcinoma of Head and Neck

1 location in Boston

Sponsor: Massachusetts Eye and Ear Infirmary

Sex: All·Age: 18+

Code: NCT06744296·Recruiting·Listed Dec 2024

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Targeting Reactive Oxygen Species Production as a Novel Therapeutic in Fuch's Endothelial Corneal Dystrophy

for Fuchs Endothelial Corneal Dystrophy

1 location in Boston

Sponsor: Massachusetts Eye and Ear Infirmary

Sex: All·Age: 21+

Code: NCT04440280·Phase 2·Recruiting·Listed Jun 2020

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Paid clinical trials in Boston, MA · Massachusetts clinical trials