Clinical Trials at Children's Hospital Colorado

As of June 2026, 185 paid clinical trials are recruiting at Children's Hospital Colorado in Aurora, Colorado. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 3, 2026.

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185 clinical trials at Children's Hospital Colorado

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A Study With Tovorafenib (DAY101) as a Treatment Option for Progressive, Relapsed, or Refractory Langerhans Cell Histiocytosis

for Recurrent Langerhans Cell Histiocytosis

104 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 180 Days - 22

Code: NCT05828069·Phase 2·Recruiting

Apply to this trial

OLE Study of Carbetocin Nasal Spray for the Treatment of Hyperphagia in Prader-Willi Syndrome

for Hyperphagia in Prader-Willi Syndrome

19 locations incl. Birmingham

Sponsor: ACADIA Pharmaceuticals Inc.

Sex: All·Age: 5 - 30

Code: NCT06420297·Phase 3·Enrolling By Invitation

Depression in Youth Onset Type 2 Diabetes

for Type 2 Diabetes

1 location in Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 12 - 17

Code: NCT06285487·Not Yet Recruiting

NS-089/NCNP-02-201 in Boys With Duchenne Muscular Dystrophy (DMD)

for Duchenne Muscular Dystrophy

10 locations incl. Aurora

Sponsor: NS Pharma, Inc.

Sex: Male·Age: 4 - 14

Code: NCT05996003·Phase 2·Recruiting

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Oral Pyridoxal 5'-Phosphate for the Treatment of Patients With PNPO Deficiency

for Pyridox(am)Ine 5'-Phosphate Oxidase Deficiency

6 locations incl. Birmingham

Sponsor: Medicure

Sex: All·Age: All ages

Code: NCT04706013·Phase 3·Recruiting

Apply to this trial

Danon Disease Natural History Study

for Danon Disease

8 locations incl. Phoenix

Sponsor: Rocket Pharmaceuticals Inc.

Sex: All·Age: 8+

Code: NCT06214507·Recruiting

Apply to this trial

Pharmacokinetic Study of Venetoclax Tablets Crushed and Dissolved Into a Solution

for Hematologic Malignancy

Drug: Venetoclax

5 locations incl. Aurora

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 0 - 38

Code: NCT06131801·Recruiting

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Cabozantinib With Ifosfamide in Relapsed/Refractory Sarcomas

for Ewing Sarcoma

Drug: Cabozantinib

4 locations incl. San Francisco

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 5 - 40

Code: NCT06156410·Phase 1·Recruiting

Apply to this trial

Neurophysiologic Biomarkers in Rett Syndrome

for Rett Syndrome

6 locations incl. Los Angeles

Sponsor: Children's Hospital of Philadelphia

Sex: Female·Age: 1 - 18·Accepts healthy volunteers

Code: NCT05932589·Recruiting

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Pediatric Medication Therapy Management Trial

for Child, Only

1 location in Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 2 - 18

Code: NCT05761847·Recruiting

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One-4-ALL Initiative

for Literacy

1 location in Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT05454969·Recruiting

Apply to this trial

STXBP1 and SYNGAP1 Related Disorders Natural History Study

for Genetic Disease

5 locations incl. Palo Alto

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: All ages

Code: NCT06555965·Recruiting

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A Longitudinal Study Looking at the Prevalence, Risk Factors & Consequences of Persistent Post-surgical Pain in Children

for Chronic Pain

7 locations incl. San Francisco

Sponsor: Telethon Kids Institute

Sex: All·Age: Up to 16·Accepts healthy volunteers

Code: NCT06354699·Recruiting

Apply to this trial

A Novel, Regulated Gene Therapy (NGN-401) Study for Females With Rett Syndrome

for Rett Syndrome

13 locations incl. Birmingham

Sponsor: Neurogene Inc.

Sex: Female·Age: 3+

Code: NCT05898620·Phase 3·Recruiting

Apply to this trial

Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes

for Insulin Resistance

2 locations incl. Aurora

Sponsor: Colorado State University

Sex: Female·Age: 12 - 17·Accepts healthy volunteers

Code: NCT05543083·Recruiting

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A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab

for Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8

Drug: Nivolumab

390 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 5 - 60

Code: NCT05675410·Phase 3·Recruiting

Apply to this trial

TelePrEP for At-risk Youth in Colorado

for Hiv

1 location in Aurora

Sponsor: University of Colorado, Denver

Sex: Male·Age: 14 - 24·Accepts healthy volunteers

Code: NCT05520905·Recruiting

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Sinus Disease in Young Children With Cystic Fibrosis

for Cystic Fibrosis in Children

6 locations incl. Aurora

Sponsor: University of California, Los Angeles

Sex: All·Age: 2 - 8

Code: NCT06191640·Recruiting

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MEKTOVI® for the Treatment of Pediatric Adamantinomatous Craniopharyngioma

for Adamantinous Craniopharyngioma

5 locations incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 1 - 39

Code: NCT05286788·Phase 2·Recruiting

Apply to this trial

Xylitol BSI Multisite - Reduction of Bloodstream Infections From Oral Organisms in Pediatric Stem Cell Transplant

for Allogeneic Stem Cell Transplantation

3 locations incl. Aurora

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 4 Months - 25

Code: NCT05579639·Phase 2·Recruiting

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Venetoclax Basket Trial for High Risk Hematologic Malignancies

for Myelodysplastic Syndromes, de Novo

Drug: Venetoclax

5 locations incl. San Francisco

Sponsor: Andrew E. Place, MD

Sex: All·Age: 1 - 40

Code: NCT05292664·Phase 1·Recruiting

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A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma

for High Grade Osteosarcoma

Drug: Cabozantinib

174 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 40

Code: NCT05691478·Phase 2, Phase 3·Recruiting

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Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low Weight Infants

for Ductus Arteriosus, Patent

24 locations incl. Birmingham

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 7 Days - 32 Days

Code: NCT05547165·Recruiting

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A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

for Childhood Medulloblastoma

101 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 4 - 21

Code: NCT05382338·Phase 3·Recruiting

Apply to this trial

Immune Responses to Gluten

for Celiac Disease

2 locations incl. Aurora

Sponsor: Boston Children's Hospital

Sex: All·Age: 2 - 101·Accepts healthy volunteers

Code: NCT05209568·Recruiting

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AFFINITY DUCHENNE: RGX-202 Gene Therapy in Participants With Duchenne Muscular Dystrophy (DMD)

for Duchenne Muscular Dystrophy

13 locations incl. Little Rock

Sponsor: REGENXBIO Inc.

Sex: Male·Age: 1+

Code: NCT05693142·Phase 2, Phase 3·Recruiting

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ACTEMRA® for the Treatment of Pediatric Adamantinomatous Craniopharyngioma

for Adamantinomatous Craniopharyngioma

8 locations incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 1 - 39

Code: NCT05233397·Phase 2·Recruiting

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Duchenne Electronic Health Record Study

for Duchenne Muscular Dystrophy (DMD)

10 locations incl. Little Rock

Sponsor: The Duchenne Registry

Sex: All·Age: All ages

Code: NCT07609394·Recruiting

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Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors

for High Grade Glioma

4 locations incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 4 - 39

Code: NCT05278208·Phase 1, Phase 2·Recruiting

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EXCOR Active Driving System for the EXCOR Pediatric VAD IDE Study

for Heart Failure

15 locations incl. Los Angeles

Sponsor: Berlin Heart, Inc

Sex: All·Age: Up to 21

Code: NCT05610787·Enrolling By Invitation

A Study to Give Treatment Inside the Eye to Treat Retinoblastoma

for Bilateral Retinoblastoma

17 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 18

Code: NCT05504291·Phase 2·Recruiting

Apply to this trial

Venetoclax in Children With Relapsed Acute Myeloid Leukemia (AML)

for Acute Myeloid Leukemia

Drug: Venetoclax

45 locations incl. Phoenix

Sponsor: PedAL BCU, LLC

Sex: All·Age: 29 Days - 21

Code: NCT05183035·Phase 3·Recruiting

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Renal Hemodynamics, Energetics and Insulin Resistance: A Follow-up Study

for Type 2 Diabetes

1 location in Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 12 - 26

Code: NCT05530356·Enrolling By Invitation

Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma

for Embryonal Rhabdomyosarcoma

165 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT05304585·Phase 3·Recruiting

Apply to this trial

A Study of Nipocalimab in Children Aged 2 to Less Than 18 Years With Generalized Myasthenia Gravis

for Myasthenia Gravis

Drug: Nipocalimab

11 locations incl. Phoenix

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 2 - 17

Code: NCT05265273·Phase 2, Phase 3·Recruiting

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An Open-label Extension Study to Evaluate Long-term Efficacy and Safety of Odevixibat in Children With Biliary Atresia

for Biliary Atresia

10 locations incl. Aurora

Sponsor: Albireo, an Ipsen Company

Sex: All·Age: All ages

Code: NCT05426733·Phase 3·Enrolling By Invitation

Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS

for Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS)

32 locations incl. Birmingham

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 1 Day - 17

Code: NCT05267821·Phase 2, Phase 3·Recruiting

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A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

for Malignant Glioma

Drug: Selinexor

109 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12 Months - 21

Code: NCT05099003·Phase 1, Phase 2·Recruiting

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Catheter-Related Early Thromboprophylaxis With Enoxaparin Studies

for Deep Venous Thrombosis

22 locations incl. Birmingham

Sponsor: Yale University

Sex: All·Age: Up to 17

Code: NCT04924322·Phase 2, Phase 3·Recruiting

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Generating Advancements Through Longitudinal Analysis in X and Y Variations (GALAXY)

for Sex Chromosome Aneuploidy

1 location in Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 0 Days - 100·Accepts healthy volunteers

Code: NCT06373861·Recruiting

Apply to this trial