Clinical Trials at Massachusetts General Hospital

As of July 2026, 599 paid clinical trials are recruiting at Massachusetts General Hospital, located at Faustman Lab at Massachusetts General Hospital, 149 13th St #3602, Boston, MA 02129, phone (617) 726-4084 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 16, 2026.

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604 clinical trials at Massachusetts General Hospital

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The RECMAP-study: Resection With or Without Intraoperative Mapping for Recurrent Glioblastoma

for Glioblastoma, IDH-wildtype

2 locations incl. San Francisco

Sponsor: Erasmus Medical Center

Sex: All·Age: Up to 90

Code: NCT06273176·Recruiting·Listed Feb 2024

Apply to this trial

The SUPRAMAX Study: Supramaximal Resection Versus Maximal Resection for High-Grade Glioma Patients (ENCRAM 2201)

for Glioblastoma

2 locations incl. San Francisco

Sponsor: Jasper Gerritsen

Sex: All·Age: 18 - 90

Code: NCT06118723·Recruiting·Listed Nov 2023

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The RESBIOP-study: Resection Versus Biopsy in High-grade Glioma Patients (ENCRAM 2202)

for Glioblastoma

2 locations incl. San Francisco

Sponsor: Jasper Gerritsen

Sex: All·Age: 18 - 90

Code: NCT06146725·Recruiting·Listed Nov 2023

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The PALSUR-study: Palliative Care Versus Surgery in High-grade Glioma Patients (ENCRAM 2203)

for Glioblastoma

2 locations incl. San Francisco

Sponsor: Jasper Gerritsen

Sex: All·Age: 18 - 90

Code: NCT06146738·Recruiting·Listed Nov 2023

Apply to this trial

Effect of Theophylline in Pseudohypoparathyroidism

for PHP Ia

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 5 - 21

Code: NCT03718403·Phase 4·Recruiting·Listed Oct 2018

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The HALT Biomarker Study

for Aortic Stenosis

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 65+

Code: NCT04552275·Phase 1·Recruiting·Listed Sep 2020

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Mindfulness-based Cognitive Therapy vs the Health Enhancement Program for Chronic Pain and Depression; The Quiet Focus Study

for Chronic Pain

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 50 - 120

Code: NCT07118722·Recruiting·Listed Aug 2025

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Folfox+Irinotecan+Chemort In Esophageal Cancer

for Gastroesophageal Junction Adenocarcinoma

Drug: Irinotecan

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04656041·Phase 2·Recruiting·Listed Dec 2020

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Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement

for Aortic Stenosis

55 locations incl. Huntsville

Sponsor: University of British Columbia

Sex: All·Age: All ages

Code: NCT04634240·Recruiting·Listed Nov 2020

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Imaging Histone Deacetylase in the Heart

for Heart Failure With Normal Ejection Fraction

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT03549559·Recruiting·Listed Jun 2018

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Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression

for Major Depressive Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 70

Code: NCT05450432·Phase 4·Recruiting·Listed Jul 2022

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Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure

for Heart Failure With Normal Ejection Fraction

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT03480633·Recruiting·Listed Mar 2018

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Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy

for Peripartum Cardiomyopathy, Postpartum

64 locations incl. Birmingham

Sponsor: Dennis M. McNamara, MD, MS

Sex: Female·Age: 18+

Code: NCT05180773·Phase 4·Recruiting·Listed Jan 2022

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ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

for Frontotemporal Lobar Degeneration (FTLD)

25 locations incl. Birmingham

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04363684·Recruiting·Listed Apr 2020

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Psychophysical and Neural Mechanisms Contributing to Chronic Post-Surgical Pain in Adolescents and Adults

for Chronic Post-surgical Pain

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 12+

Code: NCT05304286·Recruiting·Listed Mar 2022

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A Decentralized Clinical Trial to Promote Evidence-Based Care for Underserved Patients With Neurofibromatosis 1

for Neurofibromatosis 1

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: All ages

Code: NCT06262113·Recruiting·Listed Feb 2024

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Impact of Cognitive Behavioral Therapy on PTSD-CVD Link

for Posttraumatic Stress Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT06429293·Recruiting·Listed May 2024

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Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations

for Traumatic Brain Injury

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT04296604·Recruiting·Listed Mar 2020

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Psychoeducational Intervention for Patients With Hepatocellular Carcinoma

for Hepatocellular Carcinoma

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06541990·Recruiting·Listed Aug 2024

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Stroke Motor Rehabilitation and Recovery Study

for Stroke, Ischemic

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 90

Code: NCT03485040·Recruiting·Listed Apr 2018

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Safety and Efficacy of realSKIN® to Provide Complete Wound Closure of Burn Wounds as an Alternative to Autografting

for Burns Degree Third

4 locations incl. Phoenix

Sponsor: XenoTherapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06223269·Phase 3·Recruiting·Listed Jan 2024

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Testing Tumor Tissue and Blood to Help Select Personalized Treatments for Patients With Suspected Lung Cancers

for NSCLC

21 locations incl. Davis

Sponsor: Lung Cancer Mutation Consortium

Sex: All·Age: All ages

Code: NCT04712877·Recruiting·Listed Jan 2021

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Surgical Treatments for Postamputation Pain

for Residual Limb Pain

3 locations incl. Chicago

Sponsor: Prometei Pain Rehabilitation Center

Sex: All·Age: 18+

Code: NCT05009394·Recruiting·Listed Aug 2021

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Prevalence and Prediction of ATTR in Ambulatory Patients With HFpEF

for Transthyretin Amyloidosis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 65+

Code: NCT05577819·Recruiting·Listed Oct 2022

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Studying the Neuronal Basis of Human Social Cognition

for Neurosciences

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05324579·Recruiting·Listed Apr 2022

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Restor. I-131 Upt. + Selpercatinib in RET F-P RAI-R TC

for Thyroid Cancer

6 locations incl. Washington D.C.

Sponsor: Massachusetts General Hospital

Sex: All·Age: 12+

Code: NCT05668962·Phase 2·Recruiting·Listed Dec 2022

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A Clinical Trial of Pulsed-dye Laser Versus Timolol Topical Solution Versus Observation on the Growth of Hemangioma in Newborn

for Hemangioma

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: Up to 3 Months·Accepts healthy volunteers

Code: NCT01873131·Recruiting·Listed Jun 2013

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VE416 for Treatment of Food Allergy

for Peanut Allergy

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 12 - 55

Code: NCT03936998·Phase 1, Phase 2·Recruiting·Listed May 2019

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The PROGRAM-study: Awake Mapping Versus Asleep Mapping Versus No Mapping for Glioblastoma Resections

for Glioblastoma

2 locations incl. San Francisco

Sponsor: Erasmus Medical Center

Sex: All·Age: 18 - 90

Code: NCT04708171·Recruiting·Listed Jan 2021

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HIPS Feasibility Randomized Controlled Trial

for Hip Pain Chronic

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07586397·Recruiting·Listed May 2026

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Study of Denikitug (GS-1811) Given Alone or With Nivolumab or Chemotherapy in Adults With Metastatic Gastric, Gastroesophageal Junction (GEJ), and Esophageal Adenocarcinomas

for HER2-negative

Drug: Nivolumab

1 location in Boston

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT07546812·Phase 2·Recruiting·Listed Apr 2026

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Plasma and Radiologic Biomarkers of Response to ECP in Lung Transplant Recipients With CLAD

for Lung Transplant Failure and Rejection

3 locations incl. Boston

Sponsor: Brian Keller

Sex: All·Age: 7+

Code: NCT07434869·Recruiting·Listed Feb 2026

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Ivonescimab Alone And With Carboplatin/Pemetrexed For NSCLC

for Lung Cancer (NSCLC)

Drug: Ivonescimab

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07405190·Phase 2·Recruiting·Listed Feb 2026

Apply to this trial

PDT For Induction Therapy For Head And Neck Cancer

for Squamous Cell Carcinoma

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07214987·Phase 2·Recruiting·Listed Oct 2025

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EXercise and Activin Inhibition to Modulate InflammatioN Effects on Heart Failure and Cognition (EXAMINE-HFC)

for Heart Failure With Preserved Ejection Fraction

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 40+

Code: NCT07202000·Phase 2·Recruiting·Listed Oct 2025

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Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study)

for Nicotine Dependence

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT07145866·Phase 4·Recruiting·Listed Aug 2025

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A Study of LY4152199 in Participants With Previously Treated B-cell Malignancies (BAF_FRontier-1 )

for Lymphoma, Non-Hodgkin

23 locations incl. Duarte

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07101328·Phase 1·Recruiting·Listed Aug 2025

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Selinexor and Backbone Treatments of Multiple Myeloma Patients

for Multiple Myeloma

Drug: Selinexor

16 locations incl. Boston

Sponsor: Karyopharm Therapeutics Inc

Sex: All·Age: 18+

Code: NCT02343042·Phase 1, Phase 2·Recruiting·Listed Jan 2015

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Screening For BCRL In Targeted Therapy For Breast Cancer

for Lymphedema

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18 - 80

Code: NCT05142800·Recruiting·Listed Dec 2021

Apply to this trial