Clinical Trials at Massachusetts General Hospital

As of July 2026, 599 paid clinical trials are recruiting at Massachusetts General Hospital, located at Faustman Lab at Massachusetts General Hospital, 149 13th St #3602, Boston, MA 02129, phone (617) 726-4084 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 16, 2026.

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604 clinical trials at Massachusetts General Hospital

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Performance of SGM-101 for the Delineation of Primary and Recurrent Tumor and Metastases in Patients Undergoing Surgery for Colorectal Cancer

for Colorectal Neoplasms

6 locations incl. Duarte

Sponsor: Surgimab

Sex: All·Age: 18+

Code: NCT03659448·Phase 3·Recruiting·Listed Sep 2018

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Advanced Imaging to Assess the Effect of Immunosuppression on Progressive Fibrosis

for Interstitial Lung Disease

1 location in Boston

Sponsor: Peter Caravan

Sex: All·Age: 18 - 80

Code: NCT07572383·Phase 2·Recruiting·Listed May 2026

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Identifying Oxytocin Deficiency in Pediatric Patients With Pituitary Disease

for Arginine Vasopressin Deficiency

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 7 - 21

Code: NCT07568509·EARLY_Phase 1·Recruiting·Listed May 2026

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Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression

for Treatment Resistant Depression (TRD)

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07563868·Recruiting·Listed May 2026

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Falls Validation Study

for Intracranial Bleed

1 location in Boston

Sponsor: Dr. Kerstin de Wit

Sex: All·Age: 65+

Code: NCT07536906·Recruiting·Listed Apr 2026

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A Nurse-Led, Coping and Supportive Intervention for Patients With Triple-Negative Breast Cancer

for Triple Negative Breast Cancer (TNBC)

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07513311·Recruiting·Listed Apr 2026

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Remote Monitoring and Symptom Management Digital Application

for Breast Cancer (Locally Advanced or Metastatic)

1 location in Boston

Sponsor: Patrick C. Johnson, MD

Sex: All·Age: 18+

Code: NCT07553572·Recruiting·Listed Apr 2026

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PrP-targeting siRNA Safety & Mechanism Study

for Prion Disease

5 locations incl. Boston

Sponsor: Broad Institute of MIT and Harvard

Sex: All·Age: 18+

Code: NCT07444580·Phase 1·Recruiting·Listed Mar 2026

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Effects of Resistance Exercise Among TGD Individuals Initiating Estrogen-Based Gender-Affirming Hormone Therapy

for Muscle Mass and Strength

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Male·Age: 18+

Code: NCT07400419·Recruiting·Listed Feb 2026

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Testing the Effectiveness of a Novel Intervention to Improve Medication Adherence in Stroke Survivors

for Stroke

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 99

Code: NCT07414732·Recruiting·Listed Feb 2026

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Investigating Subcortical Contributions to Speech Sequencing in Deep Brain Stimulator Recipients

for Parkinson's Disease (PD)

2 locations incl. Boston

Sponsor: Boston University Charles River Campus

Sex: All·Age: 18+

Code: NCT07455760·Recruiting·Listed Mar 2026

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CC-97540 in Patients With Antineutrophil Cytoplasmic Antibody-associated Vasculitis

for Antineutrophil Cytoplasmic Antibody-associated Vasculitis

1 location in Boston

Sponsor: Marcela V. Maus, M.D.,Ph.D.

Sex: All·Age: 18+

Code: NCT07388277·Phase 1, Phase 2·Recruiting·Listed Feb 2026

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Dapagliflozin in Active Lupus Nephritis

for Lupus Nephritis (LN)

Drug: Dapagliflozin

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 70

Code: NCT07323524·Phase 4·Recruiting·Listed Jan 2026

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A Prospective Longitudinal Observational Cohort Study of Pregnant Women Residing at High Altitude in Bolivia

for Hypertensive Disorder of Pregnancy

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT07312227·Recruiting·Listed Dec 2025

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Tofersen in Non-SOD1 ALS

for ALS (Amyotrophic Lateral Sclerosis)

3 locations incl. Atlanta

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07294144·Phase 2·Recruiting·Listed Dec 2025

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Immune Response to Percutaneous Hepatic Perfusion With Melphalan for Ocular Melanoma Metastatic to the Liver

for Uveal Melanoma

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07364474·Recruiting·Listed Jan 2026

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Cardiac Effects of Mineralocorticoid Receptor Antagonism After Preeclampsia

for Hypertension

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18 - 65

Code: NCT07238400·Phase 2·Recruiting·Listed Nov 2025

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Biomarker-based Trial of NPC-1 for Alzheimer's Pathology

for Alzheimer Disease

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 55+

Code: NCT07236190·Phase 2·Recruiting·Listed Nov 2025

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Tailoring an Online Platform to Promote Evidence-Based Care for Adults With Neurofibromatosis 1 and Low Health Literacy

for Neurofibromatosis 1

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07233408·Recruiting·Listed Nov 2025

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Kisspeptin Administration Subcutaneously to Patients With Hypothalamic Amenorrhea

for Hypothalamic Amenorrhea

1 location in Boston

Sponsor: Stephanie B. Seminara, MD

Sex: Female·Age: 18 - 45

Code: NCT07224438·Phase 2·Recruiting·Listed Nov 2025

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Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease

for Reproductive Disorder

1 location in Boston

Sponsor: Stephanie B. Seminara, MD

Sex: All·Age: 18 - 60

Code: NCT07224490·Phase 1·Recruiting·Listed Nov 2025

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The Impact of Dry Needling on Electrophysiological and Ultrasound-based Biomarkers for Myofascial Pain

for Trigger Point in Trapezius Muscle

2 locations incl. Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18 - 80

Code: NCT07270276·Recruiting·Listed Dec 2025

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Time Restricted Eating (TRE) in Bipolar Disorder

for Bipolar Disorder (BD)

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT07211217·Recruiting·Listed Oct 2025

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LiverSleep: A Behavioral Sleep Intervention for Patients With Cirrhosis and Insomnia

for Cirrhosis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07417163·Recruiting·Listed Feb 2026

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Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

for Atrial Fibrillation

51 locations incl. Little Rock

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT04045665·Phase 3·Recruiting·Listed Aug 2019

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A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

for Hematologic Malignancies

142 locations incl. Birmingham

Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All·Age: All ages

Code: NCT01351545·Recruiting·Listed May 2011

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Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial - Part 2

for Intracerebral Hemorrhage

48 locations incl. Birmingham

Sponsor: Joseph Broderick, MD

Sex: All·Age: 18 - 80

Code: NCT07227246·Phase 3·Recruiting·Listed Nov 2025

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TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age

for Cystic Fibrosis (CF)

13 locations incl. Orange

Sponsor: State University of New York at Buffalo

Sex: All·Age: 18 Months - 11

Code: NCT07048574·Recruiting·Listed Jul 2025

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A Digital Health Intervention to Improve Physical Function and Wellness of Lung Cancer Survivors

for Advanced Lung Cancer

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07227623·Recruiting·Listed Nov 2025

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Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome

for Acute Respiratory Distress Syndrome

33 locations incl. Tucson

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT06066502·Phase 3·Recruiting·Listed Oct 2023

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HEALEY ALS Platform Trial - Master Protocol

for Amyotrophic Lateral Sclerosis

81 locations incl. Phoenix

Sponsor: Merit E. Cudkowicz, MD

Sex: All·Age: 18+

Code: NCT04297683·Phase 2, Phase 3·Recruiting·Listed Mar 2020

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DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes

for Gestational Diabetes Mellitus

24 locations incl. Tuscaloosa

Sponsor: Ohio State University

Sex: Female·Age: 18+

Code: NCT06445946·Phase 4·Recruiting·Listed Jun 2024

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Clinical and Genetic Evaluation of Individuals With Undiagnosed Disorders Through the Undiagnosed Diseases Network

for Genetic Disease

33 locations incl. Birmingham

Sponsor: National Human Genome Research Institute (NHGRI)

Sex: All·Age: 1 Month - 100·Accepts healthy volunteers

Code: NCT02450851·Recruiting·Listed May 2015

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Multisite Inventory of Neonatal-Perinatal Interventions (MINI) Minimum Dataset

for Infant, Extremely Premature

43 locations incl. Birmingham

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 0 - 1

Code: NCT05685745·Recruiting·Listed Jan 2023

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Imagined Acupuncture for Postoperative Pain After Spinal Surgery

for Pain Management

1 location in Boston

Sponsor: Jingping Wang, MD, Ph.D.

Sex: All·Age: 18+

Code: NCT07197710·Recruiting·Listed Sep 2025

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A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

for Glioblastoma

42 locations incl. Birmingham

Sponsor: Global Coalition for Adaptive Research

Sex: All·Age: 18+

Code: NCT03970447·Phase 2, Phase 3·Recruiting·Listed May 2019

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Chronic Subdural Hematoma Treatment With Embolization Versus Surgery Study

for Chronic Subdural Hematoma

31 locations incl. Phoenix

Sponsor: The University of Texas Medical Branch, Galveston

Sex: All·Age: 40 - 90

Code: NCT06347796·Recruiting·Listed Apr 2024

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Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

for Intracerebral Hemorrhage

187 locations incl. Birmingham

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT03907046·Phase 3·Recruiting·Listed Apr 2019

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Comparing the Efficacy of Heated Yoga and Sauna as a Treatment for Depression

for Depression Disorders

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT07082998·Recruiting·Listed Jul 2025

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CTSN Embolic Protection Trial

for Delirium

24 locations incl. North Little Rock

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 60+

Code: NCT06027788·Recruiting·Listed Sep 2023

Apply to this trial