Clinical Trials at Roswell Park Cancer Institute

As of September 2026, 148 paid clinical trials are recruiting at Roswell Park Cancer Institute, located at ELM AND CARLTON ST, BUFFALO, NY 14263, phone (716) 845-2300 in Buffalo, New York. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

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Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 24, 2026.

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148 clinical trials at Roswell Park Cancer Institute

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Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

for Ganglioneuroblastoma

Sites in Buffalo, Rochester +141 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 365 Days - 30

Code: NCT03126916·Phase 3·Recruiting·Listed Apr 2017

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Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

for Previously Treated Non-Small Cell Lung Cancer

Sites in Buffalo, Rochester +948 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT03851445·Phase 2, Phase 3·Recruiting·Listed Feb 2019

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A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia

for B Acute Lymphoblastic Leukemia Associated With Down Syndrome

Sites in Buffalo, Albany +70 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 6 - 39

Code: NCT05702645·Recruiting·Listed Jan 2023

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A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

for Childhood Medulloblastoma

Sites in Buffalo, Syracuse +100 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 4 - 21

Code: NCT05382338·Phase 3·Recruiting·Listed May 2022

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Testing the Addition of an Anti-Cancer Drug, Gemcitabine, to Usual Treatment (BCG Alone) in People Whose Non-Muscle Invasive Bladder Cancer (NMIBC) Came Back After Prior BCG Therapy

for Recurrent Non-Muscle Invasive Bladder Carcinoma

Sites in Buffalo, Harrison +56 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT07000084·Phase 3·Recruiting·Listed May 2025

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A Study About How Blood Cell Growth Patterns Relate to Heart Health After Treatment for Hodgkin Lymphoma

for Cardiovascular Disorder

Sites in Buffalo, Albany +33 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 7+

Code: NCT05705531·Recruiting·Listed Jan 2023

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Pegcetacoplan in Combination With Modified FOLFIRINOX for the Treatment of Metastatic Pancreatic Ductal Adenocarcinoma

for Metastatic Pancreatic Ductal Adenocarcinoma

Drug: Pegcetacoplan

1 location in Buffalo

Sponsor: Roswell Park Cancer Institute

Sex: All·Age: 18+

Code: NCT07214298·Phase 1, Phase 2·Recruiting·Listed Oct 2025

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Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma

for Embryonal Rhabdomyosarcoma

Sites in Buffalo, Rochester +162 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT05304585·Phase 3·Recruiting·Listed Mar 2022

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NALIRIFOX Before Surgery for the Treatment of Borderline Resectable Pancreatic Ductal Adenocarcinoma, Nectar Trial

for Borderline Resectable Pancreatic Ductal Adenocarcinoma

1 location in Buffalo

Sponsor: Roswell Park Cancer Institute

Sex: All·Age: 18+

Code: NCT06821997·Phase 2·Recruiting·Listed Feb 2025

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Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial

for Metastatic Colorectal Carcinoma

Sites in Buffalo, Harrison +52 more locations

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT05863195·Phase 3·Recruiting·Listed May 2023

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A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

for Hematologic Malignancies

Sites in Buffalo, Rochester +111 more locations

Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All·Age: All ages

Code: NCT01351545·Recruiting·Listed May 2011

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A Community Health Education Intervention for Increasing Community-driven Actions to Reduce the Cancer Burden in Western New York

for Healthy

1 location in Buffalo

Sponsor: Roswell Park Cancer Institute

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06681077·Recruiting·Listed Nov 2024

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A Phase II Study of Pemigatinib Plus Durvalumab in Previously Treated Advanced Intrahepatic Cholangiocarcinoma Patients With FGFR-2 Fusion or Rearrangement

for Intrahepatic Cholangiocarcinoma

Drug: Durvalumab

Sites in Buffalo +1 more location

Sponsor: Mehmet Akce

Sex: All·Age: 18+

Code: NCT06728410·Phase 2·Recruiting·Listed Dec 2024

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GT103 in Combination With Pembrolizumab for the Treatment of Advanced or Metastatic STK11 Mutant Non-Small Cell Lung Cancer

for Advanced Lung Non-Small Cell Carcinoma

1 location in Buffalo

Sponsor: Roswell Park Cancer Institute

Sex: All·Age: 18+

Code: NCT07017829·Phase 2·Recruiting·Listed Jun 2025

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De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

for Stage I Breast Cancer

Sites in Buffalo, Rochester +705 more locations

Sponsor: NRG Oncology

Sex: All·Age: 50 - 70

Code: NCT04852887·Phase 3·Recruiting·Listed Apr 2021

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Olanzapine for Managing Anorexia in Head and Neck Cancer Patients Undergoing Chemoradiation, MACRO Trial

for Cancer-Associated Anorexia

1 location in Buffalo

Sponsor: Roswell Park Cancer Institute

Sex: All·Age: 18+

Code: NCT06995508·Phase 2·Recruiting·Listed May 2025

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Pulmonary Suffusion in Controlling Minimal Residual Disease in Patients With Sarcoma or Colorectal Metastases

for Metastatic Bone Sarcoma

1 location in Buffalo

Sponsor: Roswell Park Cancer Institute

Sex: All·Age: 18+

Code: NCT03965234·Phase 1, Phase 2·Recruiting·Listed May 2019

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Proton or Photon RT for Retroperitoneal Sarcomas

for Retroperitoneal Sarcoma

Sites in Buffalo +9 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT01659203·Phase 1, Phase 2·Recruiting·Listed Aug 2012

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Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer

for Rectal Cancer

Sites in Buffalo, Rochester +101 more locations

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT06205485·Phase 3·Recruiting·Listed Jan 2024

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Home-based Respiratory Muscle Training for Minimizing Side Effects in Patients Undergoing Treatment for Cancer

for Breast Carcinoma

1 location in Buffalo

Sponsor: Roswell Park Cancer Institute

Sex: All·Age: 21+

Code: NCT05787834·Recruiting·Listed Mar 2023

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Mezigdomide, Carfilzomib, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma in Patients With Extramedullary Disease

for Extramedullary Disease in Multiple Myeloma

Drug: Mezigdomide

1 location in Buffalo

Sponsor: Roswell Park Cancer Institute

Sex: All·Age: 18+

Code: NCT06627751·Phase 2·Recruiting·Listed Oct 2024

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Genetically Engineered Cells (CD83 CAR T Cells) for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

for Recurrent Acute Myeloid Leukemia

1 location in Buffalo

Sponsor: Roswell Park Cancer Institute

Sex: All·Age: 18+

Code: NCT06871410·Phase 1·Recruiting·Listed Mar 2025

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Pembrolizumab Combined With Bevacizumab With or Without Agonist Anti-CD40 CDX-1140 for the Treatment of Patients With Recurrent Ovarian Cancer

for Ovarian Clear Cell Adenocarcinoma

Drug: Bevacizumab

Sites in Buffalo +1 more location

Sponsor: Roswell Park Cancer Institute

Sex: Female·Age: 18+

Code: NCT05231122·Phase 2·Recruiting·Listed Feb 2022

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MedSupport Intervention to Identify and Address Barriers to Pediatric Medication Adherence

for Acute Lymphoblastic Leukemia

1 location in Buffalo

Sponsor: Roswell Park Cancer Institute

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06323044·Recruiting·Listed Mar 2024

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High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer

for Head and Neck Squamous Cell Carcinoma

Sites in Buffalo, The Bronx +167 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06992427·Phase 3·Recruiting·Listed May 2025

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Community-Based Exercise and Nutrition Training and Education Program for Cancer Survivors

for Hematopoietic and Lymphatic System Neoplasm

1 location in Buffalo

Sponsor: Roswell Park Cancer Institute

Sex: All·Age: 18+

Code: NCT06565260·Recruiting·Listed Aug 2024

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Community-Based Physical Activity Intervention for Underserved Cancer Survivors

for Hematopoietic and Lymphoid System Neoplasm

1 location in Buffalo

Sponsor: Roswell Park Cancer Institute

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06206863·Recruiting·Listed Jan 2024

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Childhood Cancer Survivor Study

for Cancer

Sites in Buffalo, New York +25 more locations

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT01120353·Recruiting·Listed May 2010

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Dendritic Cell Vaccines Against Her2/Her3 and Pembrolizumab for the Treatment of Brain Metastasis From Triple Negative Breast Cancer or HER2+ Breast Cancer

for Anatomic Stage IV Breast Cancer AJCC v8

Sites in Buffalo +1 more location

Sponsor: Roswell Park Cancer Institute

Sex: Female·Age: 18+

Code: NCT04348747·Phase 2·Recruiting·Listed Apr 2020

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Nemtabrutinib and Pembrolizumab for the Treatment of Richter Transformation, Diffuse Large B-cell Lymphoma Subtype

for Richter Syndrome

Drug: Nemtabrutinib

1 location in Buffalo

Sponsor: Roswell Park Cancer Institute

Sex: All·Age: 18+

Code: NCT06863402·Phase 2·Recruiting·Listed Mar 2025

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Collection of Research Data and Samples From Patients Treated With Immunotherapy to Study Its Side Effects

for Hematopoietic and Lymphoid Cell Neoplasm

Sites in Buffalo, Auburn +392 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: All ages

Code: NCT04242095·Recruiting·Listed Jan 2020

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Testing the Effect of the Broccoli Seed and Sprout Extract, Avmacol ES, on the Cancer Causing Substances of Tobacco in Heavy Smokers

for Cigarette Smoking-Related Carcinoma

Sites in Buffalo +2 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05121051·Phase 2·Recruiting·Listed Nov 2021

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Tagraxofusp and Azacitidine With Venetoclax in Newly Diagnosed Secondary AML After Hypomethylating Agents

for Acute Myeloid Leukemia

Drug: Venetoclax

Sites in Buffalo +6 more locations

Sponsor: Joshua Zeidner

Sex: All·Age: 18+

Code: NCT05442216·Phase 2·Recruiting·Listed Jul 2022

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I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

for Breast Neoplasms

Sites in Buffalo, Rochester +31 more locations

Sponsor: QuantumLeap Healthcare Collaborative

Sex: All·Age: 18+

Code: NCT01042379·Phase 2·Recruiting·Listed Jan 2010

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Using Biomarker Tests to Select and Test New, Personalized Treatments for Extensive Stage Small Cell Lung Cancer, PRISM Study

for Extensive Stage Lung Small Cell Carcinoma

Sites in Buffalo, Rochester +144 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06769126·Phase 2·Recruiting·Listed Jan 2025

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A Financial Intervention (Financial Compass) to Identify and Address Financial Hardship Among Head and Neck Cancer Patients, Financial Compass Trial

for Head and Neck Carcinoma

1 location in Buffalo

Sponsor: Roswell Park Cancer Institute

Sex: All·Age: 18+

Code: NCT06896695·Recruiting·Listed Mar 2025

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Fluorescence Image Guided Surgery Followed by Intraoperative Photodynamic Therapy for Improving Local Tumor Control in Patients With Locally Advanced or Recurrent Colorectal Cancer

for Locally Advanced Colorectal Carcinoma

1 location in Buffalo

Sponsor: Roswell Park Cancer Institute

Sex: All·Age: 18+

Code: NCT06307548·Phase 1, Phase 2·Recruiting·Listed Mar 2024

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New York Better Breathing Study

for Localized Lung Carcinoma

1 location in Buffalo

Sponsor: Roswell Park Cancer Institute

Sex: All·Age: 18+

Code: NCT06869447·Recruiting·Listed Mar 2025

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Single-Fraction SBRT Versus Standard Palliative Radiation Therapy in Treating Patients With Metastatic Cancer

for Metastatic Malignant Neoplasm

Sites in Buffalo, West Islip & East Hills

Sponsor: Roswell Park Cancer Institute

Sex: All·Age: 18+

Code: NCT04068649·Phase 2·Recruiting·Listed Aug 2019

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Respiratory Muscle Training Before Surgery in Preventing Lung Complications in Patients With Stage I-IIIB Lung Cancer

for Stage I Lung Cancer AJCC v8

1 location in Buffalo

Sponsor: Roswell Park Cancer Institute

Sex: All·Age: 18+

Code: NCT04067830·Phase 2·Recruiting·Listed Aug 2019

Apply to this trial