Clinical Trials at UNC Lineberger Comprehensive Cancer Center

As of August 2026, 85 paid clinical trials are recruiting at UNC Lineberger Comprehensive Cancer Center in Chapel Hill, North Carolina. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 27, 2026.

Filter results

Filter results

State

City

Facility

Recruitment status

Phase

Study type

Intervention

Condition

Sex

Age

Healthy volunteers only

85 clinical trials at UNC Lineberger Comprehensive Cancer Center

·Clear filters·

Get a weekly email when new trials open in Chapel Hill, NC.

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

for Recurrent Head and Neck Squamous Cell Carcinoma

Sites in Chapel Hill, Greensboro +127 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 79

Code: NCT04671667·Phase 2·Recruiting·Listed Dec 2020

Apply to this trial

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

for Metastatic Head and Neck Squamous Cell Carcinoma

Sites in Chapel Hill, Pinehurst +183 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06589804·Phase 3·Recruiting·Listed Sep 2024

Apply to this trial

Testing the Addition of Lenalidomide and Nivolumab to the Usual Treatment for Primary CNS Lymphoma

for Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System

Drug: Nivolumab

Sites in Chapel Hill +42 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04609046·Phase 1·Recruiting·Listed Oct 2020

Apply to this trial

Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia

for Acute Leukemia of Ambiguous Lineage

Drug: Venetoclax

Sites in Chapel Hill, Durham +109 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 365 Days

Code: NCT06317662·Phase 2·Recruiting·Listed Mar 2024

Apply to this trial

Project: Every Child for Younger Patients With Cancer

for Adrenal Gland Pheochromocytoma

Sites in Chapel Hill, Durham +225 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 25

Code: NCT02402244·Recruiting·Listed Mar 2015

Apply to this trial

A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT)

for Stage I Mixed Cell Type Kidney Wilms Tumor

Sites in Chapel Hill, Durham +151 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 30

Code: NCT06401330·Phase 3·Recruiting·Listed May 2024

Apply to this trial

Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

for Buccal Mucosa Squamous Cell Carcinoma

Sites in Chapel Hill +86 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT04333537·Phase 2, Phase 3·Recruiting·Listed Apr 2020

Apply to this trial

A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma

for Low Grade Astrocytoma

Drug: Selumetinib

Sites in Chapel Hill, Durham +115 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 2 - 21

Code: NCT04166409·Phase 3·Recruiting·Listed Nov 2019

Apply to this trial

Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial

for Castration-Resistant Prostate Carcinoma

Sites in Chapel Hill +99 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06632977·Phase 2·Recruiting·Listed Oct 2024

Apply to this trial

The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study

for Acute Lymphoblastic Leukemia

Sites in Chapel Hill, Durham +154 more locations

Sponsor: PedAL BCU, LLC

Sex: All·Age: Up to 22

Code: NCT04726241·Phase 1, Phase 2·Recruiting·Listed Jan 2021

Apply to this trial

Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

for Metastatic Malignant Neoplasm in the Lung

Sites in Chapel Hill, Durham +200 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 50

Code: NCT05235165·Phase 3·Recruiting·Listed Feb 2022

Apply to this trial

A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma

for Basal Ganglia Germinoma

Sites in Chapel Hill, Winston-Salem +93 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 3 - 29

Code: NCT06368817·Phase 2·Recruiting·Listed Apr 2024

Apply to this trial

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

for Ganglioneuroblastoma, Nodular

Sites in Chapel Hill, Durham +152 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 30

Code: NCT06172296·Phase 3·Recruiting·Listed Dec 2023

Apply to this trial

Comparing the Clinical Impact of Pancreatic Cyst Surveillance Programs and Associated Biomarkers

for Pancreatic Neoplasm

Sites in Chapel Hill, Durham +333 more locations

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 50 - 75

Code: NCT04239573·Recruiting·Listed Jan 2020

Apply to this trial

Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

for Ganglioneuroblastoma

Sites in Chapel Hill, Durham +141 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 365 Days - 30

Code: NCT03126916·Phase 3·Recruiting·Listed Apr 2017

Apply to this trial

Adjuvant Therapy in POLE-Mutated and p53-Wildtype/NSMP Early Stage Endometrial Cancer RAINBO BLUE & TAPER

for Endometrial Cancer

Sites in Chapel Hill, Durham +73 more locations

Sponsor: Canadian Cancer Trials Group

Sex: Female·Age: 18+

Code: NCT05640999·Phase 2·Recruiting·Listed Dec 2022

Apply to this trial

Testing the Addition of Paclitaxel Administered Into the Abdominal Cavity Combined With Chemotherapy for Patients With Gastric Cancer Spread to the Abdominal Cavity

for Gastric Adenocarcinoma

Sites in Chapel Hill, Hillsborough +76 more locations

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT07001748·Phase 2, Phase 3·Recruiting·Listed Jun 2025

Apply to this trial

A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia

for B Acute Lymphoblastic Leukemia Associated With Down Syndrome

Sites in Chapel Hill, Winston-Salem +70 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 6 - 39

Code: NCT05702645·Recruiting·Listed Jan 2023

Apply to this trial

A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

for Childhood Medulloblastoma

Sites in Chapel Hill, Winston-Salem +100 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 4 - 21

Code: NCT05382338·Phase 3·Recruiting·Listed May 2022

Apply to this trial

Testing the Combination of the Anti-cancer Drugs ZEN003694 (ZEN-3694) and Talazoparib in Patients With Advanced Solid Tumors, The ComBET Trial

for Advanced Malignant Solid Neoplasm

Sites in Chapel Hill +21 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05327010·Phase 2·Recruiting·Listed Apr 2022

Apply to this trial

Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary Blastoma

for Pleuropulmonary Blastoma

Sites in Chapel Hill, Durham +78 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT06647953·Phase 3·Recruiting·Listed Oct 2024

Apply to this trial

The Vanguard Study: Testing a New Way to Screen for Cancer

for Bladder Carcinoma

Sites in Chapel Hill +40 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 45 - 75·Accepts healthy volunteers

Code: NCT06995898·Recruiting·Listed May 2025

Apply to this trial

Digoxin Medulloblastoma Study

for Medulloblastoma

Sites in Chapel Hill, Charlotte +15 more locations

Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All·Age: 12 Months - 30

Code: NCT06701812·Phase 2·Recruiting·Listed Nov 2024

Apply to this trial

Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma

for Embryonal Rhabdomyosarcoma

Sites in Chapel Hill, Durham +162 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT05304585·Phase 3·Recruiting·Listed Mar 2022

Apply to this trial

A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)

for Down Syndrome

Drug: Nivolumab

Sites in Chapel Hill, Durham +148 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 1 - 30

Code: NCT04546399·Phase 2·Recruiting·Listed Sep 2020

Apply to this trial

A Phase 1b Study of Menin Inhibitor SNDX- 5613 in Combination With Daunorubicin and Cytarabine in Newly Diagnosed Patients With Acute Myeloid Leukemia and NPM1 Mutated/FLT3 Wildtype or MLL/KMT2A Rearranged or NUP98 Alterations Disease

for Acute Myeloid Leukemia

Sites in Chapel Hill, Winston-Salem +19 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 75

Code: NCT05886049·Phase 1·Recruiting·Listed Jun 2023

Apply to this trial

Expanding the Support of Family Caregivers of Diverse Patients With Cancer and Diabetes

for Cancer

Sites in Chapel Hill +2 more locations

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT07061652·Recruiting·Listed Jul 2025

Apply to this trial

Testing the Effectiveness of the Anti-cancer Drug, Mirdametinib, in Treating Relapsed, Refractory Chronic Lymphocytic Leukemia

for Recurrent Chronic Lymphocytic Leukemia

Drug: Mirdametinib

Sites in Chapel Hill +7 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07061951·Phase 2·Recruiting·Listed Jul 2025

Apply to this trial

ETHAN - ET for Male BC

for Male Breast Cancer

Sites in Chapel Hill +8 more locations

Sponsor: Jose Pablo Leone

Sex: Male·Age: 18+

Code: NCT05501704·Phase 2·Recruiting·Listed Aug 2022

Apply to this trial

SPECT-CT Guided ELEctive Contralateral Neck Treatment for Patients With Lateralized Oropharyngeal Cancer

for Oropharyngeal Cancer

Sites in Chapel Hill +22 more locations

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT05451004·Phase 3·Recruiting·Listed Jul 2022

Apply to this trial

Obeticholic Acid for Prevention in Barrett's Esophagus

for Barrett Esophagus

Sites in Chapel Hill +7 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04939051·Phase 2·Recruiting·Listed Jun 2021

Apply to this trial

Itraconazole in Combination With Ablation for the Prevention of Esophageal Cancer in Patients With High-risk Barrett's Esophagus

for Barrett Esophagus

Sites in Chapel Hill +5 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06732388·Phase 2·Recruiting·Listed Dec 2024

Apply to this trial

Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer

for Anatomic Stage I Breast Cancer AJCC v8

Sites in Chapel Hill, Hillsborough +913 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05929768·Phase 3·Recruiting·Listed Jul 2023

Apply to this trial

Promoting CT Engagement for Pancreatic Cancer With App

for Pancreas Cancer

Sites in Chapel Hill +1 more location

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06252545·Recruiting·Listed Feb 2024

Apply to this trial

PREDICT-RD: ctDNA Surveillance in TNBC With Residual Disease

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07069595·Phase 2·Recruiting·Listed Jul 2025

Apply to this trial

Support Through Remote Observation and Nutrition Guidance Program for Individuals With Gastroesophageal Cancer

for GastroEsophageal Cancer

Sites in Chapel Hill +1 more location

Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All·Age: 18+

Code: NCT06497569·Recruiting·Listed Jul 2024

Apply to this trial

Molecular Residual Disease Assessment in a Representative Diverse Population of Patients With Early-stage Breast Cancer

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07025785·Recruiting·Listed Jun 2025

Apply to this trial

Harnessing Analysis RNA Expression and Molecular Subtype to Optimize Novel TherapY MBCA

for Breast Cancer

Sites in Chapel Hill & Raleigh

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 - 99

Code: NCT03769415·Recruiting·Listed Dec 2018

Apply to this trial

Effectiveness of Central Oncology Navigation and the Use of an ORN

for Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06618274·Recruiting·Listed Oct 2024

Apply to this trial

Designing Visual Tools to Enhance Cancer Surgeon Decision-making

for Prostate Cancer

Sites in Chapel Hill & Wilmington

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06965192·Recruiting·Listed May 2025

Apply to this trial