Clinical Trials at University of North Carolina

As of July 2026, 83 paid clinical trials are recruiting at University of North Carolina, located at 101 MANNING DR, CB 7512, CHAPEL HILL, NC 27514-4220, phone (919) 966-7700 in Chapel Hill, North Carolina. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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86 clinical trials at University of North Carolina

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Frontline T-cell Engager vs Autologous Stem Cell Transplant (ASCT) and Measurable Residual Disease (MRD)-Guided Sequential Intensification thERapy in Multiple Myeloma

for Multiple Myeloma, Newly Diagnosed

Sites in Chapel Hill +9 more locations

Sponsor: SCRI Development Innovations, LLC

Sex: All·Age: 19+

Code: NCT06974786·Phase 2·Recruiting·Listed May 2025

Apply to this trial

CD40 Agonist, Flt3 Ligand, and Chemotherapy in HER2 Negative Breast Cancer

for HER2-negative Breast Cancer

Sites in Chapel Hill +4 more locations

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18 - 99

Code: NCT05029999·Phase 1·Recruiting·Listed Sep 2021

Apply to this trial

Practice Facilitation as a Strategy to Improve Alcohol Treatment Adoption and Implementation in HIV Care

for Hiv

Sites in Chapel Hill +2 more locations

Sponsor: Johns Hopkins University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05241990·Recruiting·Listed Feb 2022

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The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation

for Atrial Fibrillation

Sites in Chapel Hill, Winston-Salem +85 more locations

Sponsor: Johns Hopkins University

Sex: All·Age: 22 - 85

Code: NCT05836987·Phase 3·Recruiting·Listed May 2023

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Study of Autologous CAR-T Cells Targeting B7-H3 in TNBC iC9-CAR.B7-H3 T Cells

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06347068·Phase 1·Recruiting·Listed Apr 2024

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Personalized Environment and Genes Study

for Diabetes

Sites in Chapel Hill & Research Triangle Park

Sponsor: National Institute of Environmental Health Sciences (NIEHS)

Sex: All·Age: 18 - 120·Accepts healthy volunteers

Code: NCT00341237·Recruiting·Listed Jun 2006

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Proton and Photon Consortium Registry (PPCR): A Multi Center Registry of Pediatric Patients Treated With Radiation Therapy

for Pediatric Patients Treated With Radiation Therapy

Sites in Chapel Hill +22 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: Up to 21

Code: NCT01696721·Recruiting·Listed Oct 2012

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Low Dose Aspirin for the Prevention of Postpartum Related Breast Cancer

for Breast Carcinoma

Sites in Chapel Hill +3 more locations

Sponsor: Mayo Clinic

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT05557877·Phase 2·Recruiting·Listed Sep 2022

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Promoting Resilience in Women With Breast Cancer (PRISM -MBC)

for Breast Cancer

Sites in Chapel Hill +1 more location

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06855654·Recruiting·Listed Mar 2025

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Orthognathic Speech Pathology: Phonetic Contrasts of Patients With Dental Discrepancies Pre- and Post-Treatment Analyses

for Dentofacial Abnormalities

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 15 - 40

Code: NCT04117360·Recruiting·Listed Oct 2019

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Compare Adjuvant Monotherapy With Endocrine or Accelerated Partial Breast Irradiation After Lumpectomy

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 65+

Code: NCT05472792·Phase 2·Recruiting·Listed Jul 2022

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Campath/Fludarabine/Melphalan Transplant Conditioning for Non-Malignant Diseases

for Metabolic Disorders

Sites in Chapel Hill +11 more locations

Sponsor: Washington University School of Medicine

Sex: All·Age: Up to 20

Code: NCT00920972·Phase 1, Phase 2·Recruiting·Listed Jun 2009

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Kidney Precision Medicine Project

for Acute Kidney Failure

Sites in Chapel Hill +12 more locations

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT04334707·Recruiting·Listed Apr 2020

Apply to this trial

A Novel Approach Utilizing Organ Specific Age Proteomics

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 22 - 66

Code: NCT06789653·Recruiting·Listed Jan 2025

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A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation

for AML (Acute Myelogenous Leukemia)

Sites in Chapel Hill +12 more locations

Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All·Age: 18 - 66

Code: NCT06859424·Phase 2·Recruiting·Listed Mar 2025

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The DART DELIVER-02 Study

for HIV (Human Immunodeficiency Virus)

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 65

Code: NCT07217379·Phase 1·Recruiting·Listed Oct 2025

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Impact of Sinus Surgery on Individuals With Cystic Fibrosis

for Chronic Rhinosinusitis (Diagnosis)

Sites in Chapel Hill +8 more locations

Sponsor: University of California, Los Angeles

Sex: All·Age: 18 - 99

Code: NCT04469439·Recruiting·Listed Jul 2020

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Transformative Research in Diabetic Nephropathy

for Diabetic Nephropathies

Sites in Chapel Hill +12 more locations

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 100

Code: NCT02986984·Recruiting·Listed Dec 2016

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Ultra Hypo-fractionated Adjuvant Whole Breast Radiation Therapy With Simultaneous Integrated Boost for Early-Stage Breast Cancer (H-ASSIST)

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 50+

Code: NCT06902311·Phase 2·Recruiting·Listed Mar 2025

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Fecal Microbiota Transplant National Registry

for Fecal Microbiota Transplantation

Sites in Chapel Hill +27 more locations

Sponsor: American Gastroenterological Association

Sex: All·Age: All ages

Code: NCT03325855·Recruiting·Listed Oct 2017

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Dichoptic Treatment for Amblyopia in Children 4 to 7 Years of Age

for Amblyopia

Sites in Chapel Hill, Durham +71 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 4 - 7

Code: NCT06380517·Phase 3·Recruiting·Listed Apr 2024

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A Randomized Trial to Evaluate Sequential vs Simultaneous Patching

for Amblyopia

Sites in Chapel Hill, Durham +66 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 3 - 13

Code: NCT04378790·Phase 3·Recruiting·Listed May 2020

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A Multi-Institution Study of TGFβ Imprinted, Ex Vivo Expanded Universal Donor NK Cell Infusions as Adoptive Immunotherapy in Combination With Gemcitabine and Docetaxel in Patients With Relapsed or Refractory Pediatric Bone and Soft Tissue

for Pediatric Sarcoma, Refractory

Sites in Chapel Hill, Durham +20 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 2 - 40

Code: NCT05634369·Phase 1, Phase 2·Recruiting·Listed Dec 2022

Apply to this trial

Dichoptic Treatment for Amblyopia in Children 8 to 12 Years of Age

for Amblyopia

Sites in Chapel Hill, Durham +56 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 8 - 12

Code: NCT06524882·Phase 3·Recruiting·Listed Jul 2024

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A Study of Enzalutamide, Enzalutamide in Combination With Mifepristone, or Chemotherapy in People With Metastatic Breast Cancer

for Metastatic Breast Cancer

Sites in Chapel Hill +11 more locations

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06099769·Phase 2·Recruiting·Listed Oct 2023

Apply to this trial

Physical Activity and Community EmPOWERment Project

for Intellectual Disability

Sites in Chapel Hill +1 more location

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06740162·Recruiting·Listed Dec 2024

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Maternal Newborn Health Registry

for Pregnancy Outcome Trends in Low-resource Geographic Areas

Sites in Chapel Hill +7 more locations

Sponsor: NICHD Global Network for Women's and Children's Health

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT01073475·Recruiting·Listed Feb 2010

Apply to this trial

Left vs Left Randomized Clinical Trial

for Heart Failure

Sites in Chapel Hill, Charlotte +55 more locations

Sponsor: Baylor College of Medicine

Sex: All·Age: 18+

Code: NCT05650658·Recruiting·Listed Dec 2022

Apply to this trial

National Liver Cancer Screening Trial

for Carcinoma, Hepatocellular

Sites in Chapel Hill +17 more locations

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18 - 85

Code: NCT06084234·Phase 4·Recruiting·Listed Oct 2023

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Achieving Understanding of the Natural History of Sickle Cell Trait (AUNT)

for Sickle Cell Trait

Sites in Chapel Hill, Durham +8 more locations

Sponsor: National Alliance for Sickle Cell Centers

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06071377·Recruiting·Listed Oct 2023

Apply to this trial

Quality of Pediatric Resuscitation in a Multicenter Collaborative

for Cardiac Arrest

Sites in Chapel Hill +39 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 0 - 18

Code: NCT02708134·Recruiting·Listed Mar 2016

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Health Outcomes of Parents With Cystic Fibrosis-Aim 2

for Cystic Fibrosis

Sites in Chapel Hill +17 more locations

Sponsor: University of Pittsburgh

Sex: All·Age: 18+

Code: NCT06296394·Recruiting·Listed Mar 2024

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Mirikizumab in the Treatment of Chronic Inflammatory Conditions of the Pouch

for Pouchitis

Sites in Chapel Hill +4 more locations

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 80

Code: NCT06864403·Phase 4·Recruiting·Listed Mar 2025

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TReatment of ADC-Refractory Breast CancEr With Dato-DXd or T-DXd: TRADE DXd

for Breast Cancer

Sites in Chapel Hill +10 more locations

Sponsor: Ana C Garrido-Castro, MD

Sex: All·Age: 18+

Code: NCT06533826·Phase 2·Recruiting·Listed Aug 2024

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Genetics of Charcot Marie Tooth (CMT) - Modifiers of CMT1A, New Causes of CMT2

for Charcot-Marie-Tooth Disease, Type Ia (Disorder)

Sites in Chapel Hill +16 more locations

Sponsor: University of Iowa

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT01193088·Recruiting·Listed Sep 2010

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Evaluation of the Acceptability, Appropriateness, and Feasibility/Usability of a Metastatic Breast-cancer Specific Prognostic Calculator Among Clinicians

for Metastatic Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT05440929·Recruiting·Listed Jul 2022

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Prognostic Estimates Among ICU Clinicians

for Mechanical Ventilation

Sites in Chapel Hill +1 more location

Sponsor: Rush University Medical Center

Sex: All·Age: All ages

Code: NCT06452797·Recruiting·Listed Jun 2024

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Mirikizumab Real World Protocol

for Ulcerative Colitis

Sites in Chapel Hill +7 more locations

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT06696014·Recruiting·Listed Nov 2024

Apply to this trial

Rifaximin for the Secondary Prevention of Recurrent Pouchitis

for Pouchitis

Sites in Chapel Hill +1 more location

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 74

Code: NCT06312683·Phase 4·Recruiting·Listed Mar 2024

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Study of Efficacy and Adherence to Subcutaneous vs. Intravenous Vedolizumab in Patients With Inflammatory Bowel Disease Using a Novel Remote MONITORing Intervention

for Inflammatory Bowel Disease (IBD)

Sites in Chapel Hill +5 more locations

Sponsor: Mercy Medical Center

Sex: All·Age: 18+

Code: NCT06750731·Recruiting·Listed Dec 2024

Apply to this trial