Clinical Trials at University of North Carolina at Chapel Hill

As of June 2026, 146 paid clinical trials are recruiting at University of North Carolina at Chapel Hill in Chapel Hill, North Carolina. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 3, 2026.

Filter results

Filter results

State

City

Facility

Phase

Study type

Intervention

Recruitment status

Condition

Sex

Age

Healthy volunteers only

146 clinical trials at University of North Carolina at Chapel Hill

·Clear filters·↓ Download CSV

A Study of Amivantamab Alone or in Addition to Other Treatment Agents in Participants With Head and Neck Cancer

for Squamous Cell Carcinoma of Head and Neck

Drug: Amivantamab

14 locations incl. La Jolla

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06385080·Phase 1, Phase 2·Recruiting

Apply to this trial

Evaluating a National Person-Centered Training Program to Strengthen the Dementia Care Workforce

for Aging

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06239688·Recruiting

Apply to this trial

Study on Efficacy and Safety of Givinostat Versus Hydroxyurea in Patients With Polycythemia Vera

for Polycythemia Vera

Drug: Givinostat

14 locations incl. Birmingham

Sponsor: Italfarmaco

Sex: All·Age: 18+

Code: NCT06093672·Phase 3·Recruiting

Apply to this trial

The Osteoarthritis Prevention Study

for Osteoarthritis, Knee

3 locations incl. Boston

Sponsor: Wake Forest University

Sex: Female·Age: 50+·Accepts healthy volunteers

Code: NCT05946044·Recruiting

Apply to this trial

A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events

for Diabetes Mellitus, Type 2

124 locations incl. Chandler

Sponsor: Cleerly, Inc.

Sex: All·Age: 55+·Accepts healthy volunteers

Code: NCT06112418·Recruiting

Apply to this trial

3-D Tractography FUS Ablation for Essential Tremor

for Essential Tremor

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 22+

Code: NCT06331052·Recruiting

Apply to this trial

Mycobacteriophage Treatment of Non-tuberculosis Mycobacteria

for Cystic Fibrosis

18 locations incl. Birmingham

Sponsor: National Jewish Health

Sex: All·Age: 6+

Code: NCT06262282·Enrolling By Invitation

Comparing Cognitive-Behavioral Therapy Versus Mindfulness-Based Therapy for Autistic Adults

for Autism Spectrum Disorder

2 locations incl. Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT06060860·Recruiting

Apply to this trial

Zenith® Fenestrated+ Clinical Study

for Aortic Aneurysm, Abdominal

32 locations incl. Birmingham

Sponsor: Cook Research Incorporated

Sex: All·Age: 18+

Code: NCT04875429·Recruiting

Apply to this trial

Transforming Hemodialysis-Related Vascular Access Education

for Chronic Kidney Disease

3 locations incl. Baltimore

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05997875·Recruiting

Apply to this trial

Evaluation of the GORE® Ascending Stent Graft

for Aortic Aneurysm, Thoracic

41 locations incl. Birmingham

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT05800743·Enrolling By Invitation

Integrating Biological, Clinical, and Behavioral Factors to Improve Breast Cancer Outcomes - Carolina Breast Cancer Study

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 20 - 74

Code: NCT07214610·Recruiting

Apply to this trial

Study of EXE-346 Live Biotherapeutic to Reduce High Bowel Movement Frequency in Subjects With an IPAA (PROF)

for Ileal Pouch

8 locations incl. Los Angeles

Sponsor: Exegi Pharma, LLC

Sex: All·Age: 18+

Code: NCT05938465·Phase 1, Phase 2·Recruiting

Apply to this trial

Performance and Safety of a Digital Tool for Unsupervised Self-assessment of NMOSD

for Neuromyelitis Optica

10 locations incl. Los Angeles

Sponsor: Ad scientiam

Sex: All·Age: 18+

Code: NCT05566769·Recruiting

Apply to this trial

Precision Medicine and Physical Function

for Frailty

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 65 - 85

Code: NCT05877846·Recruiting

Apply to this trial

GI Alpha-Gal Study

for Alpha-Gal Syndrome

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 99

Code: NCT06268717·Recruiting

Apply to this trial

A Study of Peluntamig (PT217) in Patients With Neuroendocrine Carcinomas Expressing DLL3 (the SKYBRIDGE Study)

for Small Cell Lung Cancer (SCLC)

12 locations incl. Duarte

Sponsor: Phanes Therapeutics

Sex: All·Age: 18+

Code: NCT05652686·Phase 1, Phase 2·Recruiting

Apply to this trial

Targeted Motor Learning to Improve Gait for Individuals With Parkinson Disease

for Parkinson Disease

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 50 - 80

Code: NCT05864157·Recruiting

Apply to this trial

Observational Study for Patients at Risk for Chronic Graft-Versus-Host Disease

for cGVHD

32 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT05919511·Recruiting

Apply to this trial

The Nightlight Falls Prevention Study

for Aging

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT05973448·Enrolling By Invitation

Glaucoma Drainage Device and Endothelial Cell Loss Compare Trial

for Glaucoma

7 locations incl. San Francisco

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05924477·Recruiting

Apply to this trial

Gait Rehabilitation to Treat FastOA

for Anterior Cruciate Ligament Injuries

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 16 - 35

Code: NCT05848622·Recruiting

Apply to this trial

Accountability for Care Through Undoing Racism & Equity for Moms

for Pregnancy Related

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: Female·Age: 12 - 99·Accepts healthy volunteers

Code: NCT05484804·Recruiting

Apply to this trial

Distal Radius Interventions for Fracture Treatment

for Fracture Distal Radius

25 locations incl. Phoenix

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 4 - 10

Code: NCT05131685·Recruiting

Apply to this trial

Comparison of CE-DBT and MRI in Patients With Known Breast Lesions

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 18+

Code: NCT05754749·EARLY_Phase 1·Recruiting

Apply to this trial

Evaluation of Endometriosis With 18F-fluorofuranylnorprogesterone PET / MRI

for Endometriosis

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: Female·Age: 18 - 55

Code: NCT05480995·Phase 2·Recruiting

Apply to this trial

An Extension Study to Assess Long-Term Safety of Eplontersen in Adults With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)

for Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)

46 locations incl. Scottsdale

Sponsor: Ionis Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT05667493·Phase 3·Enrolling By Invitation

Depression, Aging, Stress and Heart Health Study

for Menopause

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: Female·Age: 44 - 55·Accepts healthy volunteers

Code: NCT05570721·Recruiting

Apply to this trial

Seattle Biopsy Protocol Versus Wide-Area Transepithelial Sampling in Patients With Barrett's Esophagus Undergoing Surveillance

for Barrett Esophagus

14 locations incl. Gilbert

Sponsor: University of Colorado, Denver

Sex: All·Age: 18 - 89

Code: NCT05530343·Recruiting

Apply to this trial

A 2-Part Study to Learn Whether Litifilimab (BIIB059) Injections Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus

for Subacute Cutaneous Lupus Erythematosus

61 locations incl. Anniston

Sponsor: Biogen

Sex: All·Age: 18+

Code: NCT05531565·Phase 2, Phase 3·Recruiting

Apply to this trial

A Phase 2 Study of ACR-368 in Endometrial Adenocarcinoma

for Endometrial Adenocarcinoma

69 locations incl. Mobile

Sponsor: Acrivon Therapeutics

Sex: Female·Age: 18+

Code: NCT05548296·Phase 2·Recruiting

Apply to this trial

A Comparison of Two Brief Suicide Prevention Interventions Tailored for Youth on the Autism Spectrum

for Suicidal Ideation

5 locations incl. Baltimore

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 12 - 99

Code: NCT05398250·Enrolling By Invitation

A Study to Examine the Effects of Novel Therapy Linvoseltamab in Combination With Other Cancer Treatments for Adult Patients With Multiple Myeloma That is Resistant to Current Standard of Care Treatments

for Multiple Myeloma

Drug: Linvoseltamab

13 locations incl. La Jolla

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05137054·Phase 1·Recruiting

Apply to this trial

Sitting Interruption and Whole-body Cardiovascular Health

for Sedentary Behavior

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 30 - 60·Accepts healthy volunteers

Code: NCT05316571·Recruiting

Apply to this trial

Specialty Compared to Oncology Delivered Palliative Care for Patients With Acute Myeloid Leukemia

for Relapsed Adult AML

20 locations incl. Birmingham

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 120·Accepts healthy volunteers

Code: NCT05237258·Recruiting

Apply to this trial

Examining the Effects of Estradiol on Neural and Molecular Response to Reward

for Depression

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: Female·Age: 45 - 55

Code: NCT05282277·Phase 4·Recruiting

Apply to this trial

4D-710 in Adult Patients With Cystic Fibrosis

for Cystic Fibrosis Lung

20 locations incl. Birmingham

Sponsor: 4D Molecular Therapeutics

Sex: All·Age: 18+

Code: NCT05248230·Phase 2·Recruiting

Apply to this trial

Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial

for Schizophrenia

7 locations incl. Los Angeles

Sponsor: New York State Psychiatric Institute

Sex: All·Age: 18 - 65

Code: NCT05208190·Phase 4·Recruiting

Apply to this trial

Study of Stereotactic Radiosurgery With Olaparib Followed by Durvalumab and Physician's Choice Systemic Therapy in Subjects With Breast Cancer Brain Metastases

for Breast Cancer

Drug: Durvalumab

7 locations incl. Birmingham

Sponsor: Colette Shen

Sex: All·Age: 18+

Code: NCT04711824·Phase 1, Phase 2·Recruiting

Apply to this trial

Azithromycin Treatment for Respiratory Syncytial Virus-induced Respiratory Failure in Children

for Respiratory Syncytial Virus Infections

15 locations incl. Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 3 Days - 2

Code: NCT05026749·Phase 3·Recruiting

Apply to this trial