Paid Clinical Trials in Chapel Hill, NC

As of June 2026, 736 paid clinical trials are recruiting in Chapel Hill, North Carolina. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 26, 2026.

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736 clinical trials

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Supporting Just-In-Time Consent for Prenatal Screening: The INFORM Study

for Delivery of Health Care

3 locations incl. San Francisco

Sponsor: Case Western Reserve University

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT07557303·Not Yet Recruiting

Clinical Outcomes of 3D Printed and Milled Complete Dentures

for Edentulous Mouth

1 location in Chapel Hill

Sponsor: Dentsply Sirona Implants and Consumables

Sex: All·Age: 18+

Code: NCT07586774·Not Yet Recruiting

Testing the Effectiveness of the Anti-cancer Drug, Mirdametinib, in Treating Relapsed, Refractory Chronic Lymphocytic Leukemia

for Recurrent Chronic Lymphocytic Leukemia

8 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07061951·Phase 2·Recruiting

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Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV

for Major Depressive Disorder

25 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 70

Code: NCT06705478·Phase 2·Recruiting

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Study of INCA036978 in Participants With Myeloproliferative Neoplasms

for Myeloproliferative Neoplasms

Drug: INCA036978

22 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT07441694·Phase 1·Recruiting

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Reducing Post-Operative Opioid Prescribing in Southeastern North Carolina

for Opioid Prescribing

2 locations incl. Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT07566182·Not Yet Recruiting

Collaboration for Down Syndrome Progress (CDP)

for Down Syndrome

16 locations incl. Orange

Sponsor: RTI International

Sex: All·Age: All ages

Code: NCT07625579·Recruiting

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Dental-Child Interaction Training

for Behavior and Behavior Mechanisms

4 locations incl. Fayetteville

Sponsor: University of Florida

Sex: All·Age: 18 - 99

Code: NCT06138405·Recruiting

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Horizon Two: HR NDMM (MMRC-100)

for High Risk Newly Diagnosed Multiple Myeloma

7 locations incl. Atlanta

Sponsor: Multiple Myeloma Research Consortium

Sex: All·Age: 18+

Code: NCT07053436·Phase 2·Recruiting

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Recovering Sleep After Trauma

for Post-traumatic Stress Disorder

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 65

Code: NCT07196332·Recruiting

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Study of Oral Food Challenge Biomarkers (SAFER)

for Allergy

10 locations incl. Little Rock

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 12 Months - 17

Code: NCT07279467·Not Yet Recruiting

Testing the Addition of Anti-Cancer Drug Sonrotoclax, to the Standard Treatment Zanubrutinib, for Previously Untreated CLL/SLL

for Chronic Lymphocytic Leukemia

Drug: Sonrotoclax

141 locations incl. Los Angeles

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 65+

Code: NCT07321652·Phase 3·Recruiting

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Comparison of Performance Using MED-EL Automatic Sound Management

for Hearing Loss, Sensorineural

1 location in Chapel Hill

Sponsor: Med-El Corporation

Sex: All·Age: 18+

Code: NCT07500311·Enrolling By Invitation

Mast Cell Treatment in Post-tick Bite Illness (PTBI)

for Post-tick Bite Illness

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 21 - 65·Accepts healthy volunteers

Code: NCT07526558·Phase 2·Not Yet Recruiting

GLOW Study: Effects of Triple Protein in Women

for Healthy Women

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: Female·Age: 30 - 60·Accepts healthy volunteers

Code: NCT07526571·Recruiting

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Comparing the Effects of Front-of-Package Labeling Schemes in Indonesia

for Nutrition

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07526584·Not Yet Recruiting

Descartes-08 in Autoantibody Myositis

for Antisynthetase Syndrome

2 locations incl. Chapel Hill

Sponsor: Cartesian Therapeutics

Sex: All·Age: 18+

Code: NCT07391605·Phase 2·Recruiting

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Tirzepatide in Obesity-Driven Endometrial Cancer

for Endometrial Cancer

Drug: Tirzepatide

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 18+

Code: NCT07065552·EARLY_Phase 1·Recruiting

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Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer

for Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

83 locations incl. Tucson

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07195734·Phase 2·Recruiting

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Pilot Study of Communication for Dual Users of Cigarettes and E-cigarettes

for Tobacco Products

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07599462·Recruiting

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HomeGrown: A Family-based Lifestyle Intervention to Support Healthy Development of Young Children With Down Syndrome

for Down Syndrome

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07296861·Recruiting

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CARED : A Novel Rapid Treatment Paradigm for Depression

for Major Depressive Disorder

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 70

Code: NCT07507370·Recruiting

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Menopausal HT for Women Living With HIV (HoT)

for HIV Infection

23 locations incl. Birmingham

Sponsor: Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

Sex: Female·Age: 40 - 60

Code: NCT06856174·Phase 4·Recruiting

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A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma

for Solid Tumors

Drug: INCB161734

68 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT07522073·Phase 3·Recruiting

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A U.S. Pilot Human Investigation of RadiofrEquency Vapor Ablation System to Evaluate Safety, TOleRability, and Effectiveness for Proximal Intestinal Mucosal Ablation in Patients With Type 2 Diabetes Mellitus (RESTORE-1 Study)

for Type-2 Diabetes Mellitus

4 locations incl. Scottsdale

Sponsor: Aqua Medical, Inc.

Sex: All·Age: 22 - 65

Code: NCT07355270·Recruiting

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AI-CARE: Artificial Intelligence for Cardiovascular Analysis and Risk Evaluation

for Aortic Aneurysm

2 locations incl. Chapel Hill

Sponsor: Aiatella Oy

Sex: All·Age: 22+·Accepts healthy volunteers

Code: NCT07438327·Recruiting

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Okami Medical ALPHA Registry

for Arterial Bleed

3 locations incl. Aurora

Sponsor: Okami Medical, Inc.

Sex: All·Age: 18+

Code: NCT07525518·Enrolling By Invitation

AI Tool to Reduce Clinician Documentation Burden

for Burnout, Healthcare Workers

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07498582·Enrolling By Invitation

How [14C]-DSP-5336 is Absorbed, Broken Down, and Removed From the Body After a Single Oral Dose in Patients With Advanced Blood Cancers

for Advanced Hematologic Malignancies

2 locations incl. Chapel Hill

Sponsor: Sumitomo Pharma America, Inc.

Sex: All·Age: 18+

Code: NCT07444268·Phase 1·Recruiting

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Piloting a Generative Artificial Intelligence Chatbot in a Mobile Weight Loss Program

for Overweight and/or Obesity

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 39·Accepts healthy volunteers

Code: NCT07534254·Recruiting

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Comparing Over the Counter Pain Medicines for Discomfort in Crohn's Disease (AVID-CD)

for Crohn's Disease (CD)

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: Female·Age: 18 - 44

Code: NCT07337902·Recruiting

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Preoperative Chemotherapy, Pembrolizumab and Low or High Dose RADiation in an Expansion Cohort of Node(+), Triple Negative Breast Cancer

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07276880·Phase 2·Recruiting

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Local Radiofrequency Ablation Plus External Beam Radiation for the Treatment of Painful Thoracic and Lumbar Spine Tumors

for Thoracic Neoplasms

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07479199·Recruiting

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A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204)

for Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma

Drug: Nivolumab

34 locations incl. Phoenix

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07221149·Phase 2, Phase 3·Recruiting

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A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer

for CRC (Colorectal Cancer)

Drug: Bevacizumab

80 locations incl. Chandler

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT07284849·Phase 3·Recruiting

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A Study Exploring Changes in a Variety of Biomarkers Following Dosing With MT1988 in Participants at Clinical High Risk for Psychosis

for Clinical High Risk for Psychosis (CHR)

15 locations incl. Irvine

Sponsor: Monument Therapeutics Limited

Sex: All·Age: 17 - 30

Code: NCT07226895·Phase 1, Phase 2·Recruiting

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Adolescent Mental Health Parenting Program for Child-Adult Relationship Enhancement

for Adolescent Behavior

2 locations incl. Cary

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT07303062·Not Yet Recruiting

BandPass: A Remote Monitoring System for Sarcopenia and Functional Decline Phase II Aim 4

for Sarcopenia

2 locations incl. Chapel Hill

Sponsor: SynchroHealth LLC

Sex: All·Age: 65+

Code: NCT07421648·Not Yet Recruiting

Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections

for Gonorrhea

13 locations incl. Los Angeles

Sponsor: Westat

Sex: Female·Age: 13 - 29

Code: NCT06738407·Phase 4·Recruiting

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PREDICT-RD: ctDNA Surveillance in TNBC With Residual Disease

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07069595·Phase 2·Recruiting

Apply to this trial