Clinical Trials at Medical University of South Carolina

As of August 2026, 345 paid clinical trials are recruiting at Medical University of South Carolina, located at 96 JONATHAN LUCAS ST, SUITE 309, CHARLESTON, SC 29425-8900, phone (843) 792-3221 in Charleston, South Carolina. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 13, 2026.

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350 clinical trials at Medical University of South Carolina

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A Study of Nipocalimab Administered to Adults With Generalized Myasthenia Gravis

for Myasthenia Gravis

Drug: Nipocalimab

Sites in Charleston +10 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT04951622·Phase 3·Recruiting·Listed Jul 2021

Apply to this trial

Melodi Matrix™ in Breast Reconstruction

for Breast Reconstruction

Sites in Charleston +9 more locations

Sponsor: Melodi Health, Inc.

Sex: Female·Age: 22+

Code: NCT06027996·Recruiting·Listed Sep 2023

Apply to this trial

Cardiac RADIoablation Versus Repeat Catheter Ablation: a Pivotal Randomized Clinical Trial Evaluating Safety and Efficacy for Patients With High-risk Refractory Ventricular Tachycardia (RADIATE-VT)

for Tachycardia, Ventricular

Sites in Charleston +10 more locations

Sponsor: Varian, a Siemens Healthineers Company

Sex: All·Age: 18+

Code: NCT05765175·Recruiting·Listed Mar 2023

Apply to this trial

Pivotal Study for the Cardiac Performance System (CPS)

for Cardiovascular Diseases

Sites in Charleston +9 more locations

Sponsor: Sensydia Corporation

Sex: All·Age: 18+

Code: NCT06870591·Recruiting·Listed Mar 2025

Apply to this trial

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

for Brain Cancer

Sites in Charleston, Florence +14 more locations

Sponsor: Adela, Inc

Sex: All·Age: 40+·Accepts healthy volunteers

Code: NCT05366881·Recruiting·Listed May 2022

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Treatment of Pulmonary Arterial Hypertension Using the Aria CV Pulmonary Hypertension System

for Pulmonary Arterial Hypertension

Sites in Charleston +8 more locations

Sponsor: Aria CV, Inc

Sex: All·Age: 18+

Code: NCT04555161·Recruiting·Listed Sep 2020

Apply to this trial

uTRACT Jelmyto Registry: A Registry of Patients With Upper Tract Urothelial Cancer (UTUC) Treated With Jelmyto

for Urothelial Carcinoma

Sites in Charleston +21 more locations

Sponsor: UroGen Pharma Ltd.

Sex: All·Age: 18+

Code: NCT05874921·Recruiting·Listed May 2023

Apply to this trial

An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement System

for Mitral Regurgitation

Sites in Charleston +7 more locations

Sponsor: HighLife SAS

Sex: All·Age: 18+

Code: NCT04029337·Recruiting·Listed Jul 2019

Apply to this trial

Nafamostat Efficacy in Phase 3 Registrational CRRT Study

for Acute Kidney Injury

Sites in Charleston +9 more locations

Sponsor: Talphera, Inc

Sex: All·Age: 18 - 80

Code: NCT06150742·Recruiting·Listed Nov 2023

Apply to this trial

Specimen Collection from Pregnant Women At Increased Risk for Fetal Aneuploidy

for Down Syndrome

Sites in Charleston +11 more locations

Sponsor: Sequenom, Inc.

Sex: Female·Age: 18+

Code: NCT01429389·Recruiting·Listed Sep 2011

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Post Approval Study for Treatment of Drug-resistant Adult and Pediatric Primary FSGS Using the LIPOSORBER® LA-15 System

for Focal Segmental Glomerulosclerosis

Sites in Charleston +9 more locations

Sponsor: Kaneka Medical America LLC

Sex: All·Age: Up to 75

Code: NCT04065438·Recruiting·Listed Aug 2019

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A Phase 1 AAV Gene Therapy Trial Evaluating Safety and Preliminary Efficacy of RP-A701 in Subjects With BAG3 Dilated Cardiomyopathy

for Dilated Cardiomyopathy (DCM)

Sites in Charleston +2 more locations

Sponsor: Rocket Pharmaceuticals Inc.

Sex: All·Age: 18 - 65

Code: NCT07137338·Phase 1·Recruiting·Listed Aug 2025

Apply to this trial

A Long-term Study of the Medicine Called Abrocitinib in Children Aged 2 Years and Older With Moderate to Severe Eczema

for Atopic Dermatitis

Sites in Charleston, Greenville +7 more locations

Sponsor: Pfizer

Sex: All·Age: 2 - 11

Code: NCT06807281·Phase 3·Recruiting·Listed Feb 2025

Apply to this trial

Trial Investigating Visugromab in Combination With Immunochemotherapy in 1L Treatment of Participants With Metastatic NSCLC

for Metastatic Non-Squamous Non-Small Cell Lung Cancer

Sites in Charleston +6 more locations

Sponsor: CatalYm GmbH

Sex: All·Age: 18+

Code: NCT07098988·Phase 2·Recruiting·Listed Aug 2025

Apply to this trial

The TRICURE EFS Study

for Tricuspid Valve Regurgitation

Sites in Charleston +7 more locations

Sponsor: TRiCares

Sex: All·Age: 18+

Code: NCT06506942·Recruiting·Listed Jul 2024

Apply to this trial

SPI-1005 in Adults Receiving Cochlear Implant

for Hearing Loss

Sites in Charleston +5 more locations

Sponsor: Sound Pharmaceuticals, Incorporated

Sex: All·Age: 18+

Code: NCT06340633·Phase 2·Recruiting·Listed Apr 2024

Apply to this trial

Real Life Evaluation of the LibAirty Airway Clearance System in Adults With Bronchiectasis (RELACS)

for Bronchiectasis Adult

Sites in Charleston +2 more locations

Sponsor: Synchrony-Medical, Ltd

Sex: All·Age: 21+

Code: NCT07135284·Recruiting·Listed Aug 2025

Apply to this trial

Contour Neurovascular System™ ContiNued Access Investigational Device EXempTion (IDE) Trial (NEXT Trial)

for Cerebral Aneurysms

Sites in Charleston +8 more locations

Sponsor: Cerus Endovascular, Inc.

Sex: All·Age: 18 - 75

Code: NCT06693011·Recruiting·Listed Nov 2024

Apply to this trial

A Study to Investigate APL-5125 in Adults With Advanced Solid Tumors

for Colorectal Cancer

Sites in Charleston +6 more locations

Sponsor: Apollo Therapeutics Ltd

Sex: All·Age: 18+

Code: NCT06399757·Phase 1, Phase 2·Recruiting·Listed May 2024

Apply to this trial

ViewFlex X ICE First-in-Human Study

for Cardiac Arrhythmias

Sites in Charleston +7 more locations

Sponsor: Abbott Medical Devices

Sex: All·Age: 18+

Code: NCT06772493·Recruiting·Listed Jan 2025

Apply to this trial

Saline Enhanced Radiofrequency (SERF) Needle Ablation for Refractory VT

for Refractory Ventricular Tachycardia

Sites in Charleston +4 more locations

Sponsor: Thermedical, Inc.

Sex: All·Age: 18+

Code: NCT05337241·Recruiting·Listed Apr 2022

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Patient Specific Talus Spacer Post Approval Study

for Avascular Necrosis of the Talus

Sites in Charleston +5 more locations

Sponsor: Paragon 28

Sex: All·Age: 21+

Code: NCT05364606·Recruiting·Listed May 2022

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Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)

for Arrhythmogenic Right Ventricular Cardiomyopathy

Sites in Charleston +7 more locations

Sponsor: Tenaya Therapeutics

Sex: All·Age: 14 - 65

Code: NCT06311708·Recruiting·Listed Mar 2024

Apply to this trial

A Study of KB408 for the Treatment of Alpha-1 Antitrypsin Deficiency

for Alpha 1-Antitrypsin Deficiency

Sites in Charleston +2 more locations

Sponsor: Krystal Biotech, Inc.

Sex: All·Age: 18 - 70

Code: NCT06049082·Phase 1·Recruiting·Listed Sep 2023

Apply to this trial

UC-MSC Cell Therapy Study for Systemic Lupus Erythematosus (SLE) Patients

for SLE

1 location in Charleston

Sponsor: LiveKidney.Bio

Sex: All·Age: 18 - 75

Code: NCT06737380·Phase 1·Recruiting·Listed Dec 2024

Apply to this trial

Project Mountain - Comparing SpO2 and SaO2 for Accuracy

for SpO2

Sites in Charleston +4 more locations

Sponsor: Philips Clinical & Medical Affairs Global

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06372106·Recruiting·Listed Apr 2024

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Impact of Capturing Ictal Events With Ultra-long-term Ambulatory EEG Monitoring With Remote EEG Monitoring System.

for Epilepsy

Sites in Charleston +1 more location

Sponsor: Epitel, Inc.

Sex: All·Age: 18 - 70

Code: NCT06027749·Recruiting·Listed Sep 2023

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Digitally Enhanced Stepped-Care for Depression in Primary Care

for Depression

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07634705·Recruiting·Listed Jun 2026

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A Pragmatic Clinical Trial of the WE BEAT Well-Being Education Program in Adolescent Congenital Heart Disease: WE BEAT CHD Study

for Patient-Reported Outcome Measures (PROMs)

Sites in Charleston +13 more locations

Sponsor: Carelon Research

Sex: All·Age: 12 - 17

Code: NCT07525843·Recruiting·Listed Apr 2026

Apply to this trial

At-home taVNS for Neurorehabilitation in Parkinson's Disease

for Parkinson's Disease

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 40 - 85

Code: NCT07536022·Recruiting·Listed Apr 2026

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Omission of Postoperative Radiation in HPV-Associated Oropharyngeal Cancer Using ctHPVDNA Surveillance (OPERATION)

for Squamous Cell Carcinoma

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07513389·Phase 2·Recruiting·Listed Apr 2026

Apply to this trial

Brain Stimulation and Cognitive Training for MCI

for Mild Cognitive Impairment (MCI)

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 60 - 85

Code: NCT07526740·Recruiting·Listed Apr 2026

Apply to this trial

taVNS + CCT for Neurocognitive Rehab

for Psychosocial Well-being

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 45 - 80

Code: NCT07517237·Recruiting·Listed Apr 2026

Apply to this trial

Pilot of Mailing Buprenorphine

for Opioid Use Disorder

2 locations in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07421102·EARLY_Phase 1·Recruiting·Listed Feb 2026

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Exoskeleton for Balance

for Stroke

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 21+

Code: NCT07356011·Recruiting·Listed Jan 2026

Apply to this trial

Accelerated TMS for Apathy in PD

for Parkinson Disease

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 45 - 85

Code: NCT07399496·Recruiting·Listed Feb 2026

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Testing Addition of an Anti-cancer Drug, Vorasidenib to Temozolomide, After Radiation for Advanced Brain Cancer

for Astrocytoma, IDH-Mutant, Grade 3

Drug: Vorasidenib

Sites in Charleston +96 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 12+

Code: NCT07215910·Phase 3·Recruiting·Listed Oct 2025

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Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

for Breast Cancer

Sites in Charleston, Hilton Head Island +1098 more locations

Sponsor: NRG Oncology

Sex: Female·Age: 18 - 60

Code: NCT05879926·Phase 3·Recruiting·Listed May 2023

Apply to this trial

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

for Lung Non-Small Cell Carcinoma

Sites in Charleston, Hilton Head Island +633 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04267848·Phase 3·Recruiting·Listed Feb 2020

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Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease

for Stage III Colon Cancer

Sites in Charleston, Union +913 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT05174169·Phase 2, Phase 3·Recruiting·Listed Dec 2021

Apply to this trial