Paid Clinical Trials in Charlotte, NC

As of July 2026, 506 paid clinical trials are recruiting in Charlotte, North Carolina. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 31, 2026.

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451 clinical trials

Sickle Cell Clinical Research and Intervention Program

for Sickle Cell Disease

Sites in Charlotte +4 more locations

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: All ages

Code: NCT02098863·Recruiting·Listed Mar 2014

Apply to this trial

Study of CM4620 to Reduce the Severity of Pancreatitis Due to Asparaginase

for Acute Pancreatitis

Sites in Charlotte +2 more locations

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: Up to 21

Code: NCT04195347·Phase 1, Phase 2·Recruiting·Listed Dec 2019

Apply to this trial

LATe Cerclage in High-risk Pregnancies (LATCH)

for Premature Birth

Sites in Charlotte +1 more location

Sponsor: Thomas Jefferson University

Sex: Female·Age: 18 - 50·Accepts healthy volunteers

Code: NCT06036446·Recruiting·Listed Sep 2023

Apply to this trial

DISCOVERY of Risk Factors for Type 2 Diabetes in Youth

for Diabetes Mellitus Type 2, Childhood-Onset

Sites in Charlotte, Winston-Salem +18 more locations

Sponsor: George Washington University

Sex: All·Age: 8 - 15

Code: NCT06525259·Recruiting·Listed Jul 2024

Apply to this trial

Supraglottic Airway for Resuscitation Trial

for Neonatal Resuscitation

Sites in Charlotte, Chapel Hill +28 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 0 Days+

Code: NCT07150923·Recruiting·Listed Sep 2025

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PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes

for Type2Diabetes

Sites in Charlotte, Durham +34 more locations

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 40 - 80

Code: NCT05390892·Phase 4·Recruiting·Listed May 2022

Apply to this trial

Single Versus Dual Implant Fixation of Distal Femur Fractures

for Articular Fractures

Sites in Charlotte, Concord +14 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06286670·Recruiting·Listed Feb 2024

Apply to this trial

CIED Infection Quality Initiative Demonstration Project

for Infections

Sites in Charlotte, Greensboro +1 more location

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT05471973·Recruiting·Listed Jul 2022

Apply to this trial

Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

for Ganglioneuroblastoma

Sites in Charlotte, Winston-Salem +143 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 365 Days - 30

Code: NCT03126916·Phase 3·Recruiting·Listed Apr 2017

Apply to this trial

Daoist Zhanzhuang and Human Flourishing

for Stress, Physiological

1 location in Charlotte

Sponsor: University of North Carolina, Charlotte

Sex: All·Age: 18 - 25·Accepts healthy volunteers

Code: NCT06573034·Recruiting·Listed Aug 2024

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Protocol for Collecting, Banking and Distributing Human Tissue Samples: St. Jude Children's Research Hospital Tissue Resources Core Facility

for Normal and Diseased Tissue and Body Fluids Samples

Sites in Charlotte +12 more locations

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT01354002·Recruiting·Listed May 2011

Apply to this trial

The SKyRoCKeT Study

for Healthy

1 location in Charlotte

Sponsor: University of North Carolina, Charlotte

Sex: All·Age: 6 - 20·Accepts healthy volunteers

Code: NCT05770817·Recruiting·Listed Mar 2023

Apply to this trial

Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma

for Diffuse Large B-Cell Lymphoma

Sites in Charlotte, Concord +81 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05633615·Phase 2·Recruiting·Listed Dec 2022

Apply to this trial

Inhaled Nitric Oxide in Acute Ischemic Stroke Patients Undergoing Mechanical Thrombectomy

for Cerebrovascular Disorders

2 locations in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18 - 80

Code: NCT05871606·Phase 1·Recruiting·Listed May 2023

Apply to this trial

Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer

for Colorectal Cancer

Sites in Charlotte, Concord +140 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 60+

Code: NCT03998202·Recruiting·Listed Jun 2019

Apply to this trial

Prehospital Analgesia INtervention Trial (PAIN)

for Traumatic Injury

Sites in Charlotte +9 more locations

Sponsor: Jason Sperry

Sex: All·Age: 18+

Code: NCT05437575·Phase 3·Recruiting·Listed Jun 2022

Apply to this trial

Physical Therapy Wound Care Modalities in Patients With Spinal Cord Injury (SCI)

for Spinal Cord Injuries

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05458947·Recruiting·Listed Jul 2022

Apply to this trial

CARE-CP (Testing a Cardiovascular Ambulatory Rapid Evaluation for Patients With Chest Pain)

for Chest Pain

Sites in Charlotte, Winston-Salem +1 more location

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 21+

Code: NCT05897632·Recruiting·Listed Jun 2023

Apply to this trial

Direct Comparison of Cardiac CT With TEE to Evaluate Watchman FLX LAA Occluder Device Characteristics

for Device Related Thrombosis

Sites in Charlotte +4 more locations

Sponsor: University Hospitals Cleveland Medical Center

Sex: All·Age: 18+

Code: NCT06523166·Recruiting·Listed Jul 2024

Apply to this trial

Enhancing Wellness Through Affirming Services and Education

for HIV

1 location in Charlotte

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT05700474·Recruiting·Listed Jan 2023

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Gastroparesis Registry 4

for Gastroparesis

Sites in Charlotte +5 more locations

Sponsor: Johns Hopkins Bloomberg School of Public Health

Sex: All·Age: 18 - 85

Code: NCT05846802·Recruiting·Listed May 2023

Apply to this trial

A Multi-Institution Study of TGFβ Imprinted, Ex Vivo Expanded Universal Donor NK Cell Infusions as Adoptive Immunotherapy in Combination With Gemcitabine and Docetaxel in Patients With Relapsed or Refractory Pediatric Bone and Soft Tissue

for Pediatric Sarcoma, Refractory

Sites in Charlotte, Chapel Hill +20 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 2 - 40

Code: NCT05634369·Phase 1, Phase 2·Recruiting·Listed Dec 2022

Apply to this trial

Clinical Trial of Upfront Haploidentical or Unrelated Donor BMT to Restore Normal Hematopoiesis in Aplastic Anemia

for Severe Aplastic Anemia

Sites in Charlotte, Chapel Hill +23 more locations

Sponsor: Medical College of Wisconsin

Sex: All·Age: 3 - 75

Code: NCT06517641·Phase 2·Recruiting·Listed Jul 2024

Apply to this trial

Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

for Castration Levels of Testosterone

Sites in Charlotte, Concord +292 more locations

Sponsor: SWOG Cancer Research Network

Sex: Male·Age: 18+

Code: NCT03678025·Phase 3·Recruiting·Listed Sep 2018

Apply to this trial

Use of an Integrated Orthotic and Rehabilitation Initiative for Treatment of Lower Extremity Musculoskeletal Disorders

for Musculoskeletal Injury

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05780502·Recruiting·Listed Mar 2023

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Minimizing Toxicity in HLA-identical Sibling Donor Transplantation for Children With Sickle Cell Disease

for Sickle Cell Disease

Sites in Charlotte +4 more locations

Sponsor: Robert Nickel

Sex: All·Age: 2 - 25

Code: NCT03587272·Phase 2·Recruiting·Listed Jul 2018

Apply to this trial

Comparison of Urinary Flow Study

for Urinary Retention

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: Female·Age: 18+

Code: NCT06918067·Recruiting·Listed Apr 2025

Apply to this trial

Multicenter Trial for Eliminating Breast Cancer Surgery or Radiotherapy in Exceptional Responders to Neoadjuvant Systemic Therapy

for Estrogen Receptor Negative

Sites in Charlotte +5 more locations

Sponsor: M.D. Anderson Cancer Center

Sex: Female·Age: 30+

Code: NCT02945579·Recruiting·Listed Oct 2016

Apply to this trial

Evaluating the Safety and Efficacy of Polyethylene Glycol (PEG) Mediated Fusion (PEG Fusion)

for Peripheral Nerve Injuries

Sites in Charlotte +6 more locations

Sponsor: Major Extremity Trauma Research Consortium

Sex: All·Age: 18 - 80

Code: NCT04789044·Phase 2·Recruiting·Listed Mar 2021

Apply to this trial

Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry

for Rheumatic Joint Disease

Sites in Charlotte, Winston-Salem +66 more locations

Sponsor: Duke University

Sex: All·Age: Up to 21

Code: NCT02418442·Recruiting·Listed Apr 2015

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A Phase II Nationwide, Fully Decentralized, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreatic Cancer With FGFR Genetic Alterations

for Advanced Pancreatic Carcinoma

Sites in Charlotte, Raleigh +107 more locations

Sponsor: Sameek Roychowdhury

Sex: All·Age: 18+

Code: NCT06906562·Phase 2·Recruiting·Listed Apr 2025

Apply to this trial

Left vs Left Randomized Clinical Trial

for Heart Failure

Sites in Charlotte, Asheville +55 more locations

Sponsor: Baylor College of Medicine

Sex: All·Age: 18+

Code: NCT05650658·Recruiting·Listed Dec 2022

Apply to this trial

StrokeNet Thrombectomy Endovascular Platform

for Ischemic Stroke

Sites in Charlotte, Winston-Salem +39 more locations

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06289985·Recruiting·Listed Mar 2024

Apply to this trial

Cancer-related Fatigue During Maintenance Immunotherapy for Non-small Cell Lung Cancer (NSCLC): a Qualitative Study

for Non-small Cell Lung Cancer

Sites in Charlotte & Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06567704·Recruiting·Listed Aug 2024

Apply to this trial

Secondary Mitral Regurgitation Treatment With MitraClip and Assessment by Cardiac Magnetic Resonance

for Heart Failure and Reduced Ejection Fraction

Sites in Charlotte +4 more locations

Sponsor: Minneapolis Heart Institute Foundation

Sex: All·Age: 18+

Code: NCT07131631·Recruiting·Listed Aug 2025

Apply to this trial

Individualizing Treatment for Asthma in Primary Care (Full Study)

for Asthma

Sites in Charlotte, Chapel Hill +11 more locations

Sponsor: DARTNet Institute

Sex: All·Age: 13 - 75

Code: NCT07052942·Phase 4·Recruiting·Listed Jul 2025

Apply to this trial

Xeomin® and Gait Related Mobility After Stroke

for Stroke

Drug: Xeomin

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18 - 79

Code: NCT04908423·Phase 4·Recruiting·Listed Jun 2021

Apply to this trial

Pelvic and Acetabular Fracture: A Prospective Observational Study

for Pelvic Fracture

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT04615104·Recruiting·Listed Nov 2020

Apply to this trial

Clinical Trial for Surgery of the Ulnar Nerve (SUN) at the Elbow

for Neuropathy Ulnar

Sites in Charlotte, Winston-Salem +7 more locations

Sponsor: University of Michigan

Sex: All·Age: 18+

Code: NCT04254185·Recruiting·Listed Feb 2020

Apply to this trial

Screening for AL Amyloidosis in Smoldering Multiple Myeloma

for Smoldering Multiple Myeloma

Sites in Charlotte, Durham +11 more locations

Sponsor: Tufts Medical Center

Sex: All·Age: 40+

Code: NCT06365060·Recruiting·Listed Apr 2024

Apply to this trial