Oncology Clinical Trials in Charlottesville, VA

As of July 2026, 106 paid clinical trials are recruiting for Oncology in Charlottesville, Virginia. Oncology trials evaluate immunotherapies, targeted therapies, antibody-drug conjugates, and combination regimens across solid tumors and blood cancers — from early-phase first-in-human studies to phase 3 registration trials. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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107 clinical trials for Oncology

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International Registry for Men With Advanced Prostate Cancer (IRONMAN)

for Prostate Cancer

Sites in Charlottesville +34 more locations

Sponsor: Prostate Cancer Clinical Trials Consortium

Sex: Male·Age: 21+

Code: NCT03151629·Recruiting·Listed May 2017

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Sotorasib in Combination With Trastuzumab Deruxtecan for the Treatment of Locally Advanced and Metastatic Non-small Cell Lung Cancer With a KRAS G12C Mutation

for Locally Advanced Lung Non-Small Cell Carcinoma

Drug: Sotorasib

Sites in Charlottesville +8 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07012031·Phase 1, Phase 2·Recruiting·Listed Jun 2025

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Study of EGFRBi Armed Fresh PBMC in Metastatic or Unresectable Pancreatic Cancer

for Pancreas Cancer

1 location in Charlottesville

Sponsor: University of Virginia

Sex: All·Age: 18+

Code: NCT06479239·Phase 1, Phase 2·Recruiting·Listed Jun 2024

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Pre-Operative Window of ET to Inform RT Decisions (POWER II)

for Breast Cancer Female

Sites in Charlottesville, Culpeper +4 more locations

Sponsor: University of Virginia

Sex: Female·Age: 65+

Code: NCT06507618·Phase 3·Recruiting·Listed Jul 2024

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Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)

for Advanced Malignant Solid Neoplasm

Sites in Charlottesville, Richmond +25 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06311214·Phase 2·Recruiting·Listed Mar 2024

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Pancreatic Cancer Early Detection Consortium

for Pancreas Cancer

Sites in Charlottesville, Richmond +41 more locations

Sponsor: Arbor Research Collaborative for Health

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT04970056·Recruiting·Listed Jul 2021

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4D-MRI for Precision Medicine

for Healthy Volunteers

1 location in Charlottesville

Sponsor: University of Virginia

Sex: All·Age: 18 - 82·Accepts healthy volunteers

Code: NCT04657042·Recruiting·Listed Dec 2020

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Cardioprotection in AML

for AML

1 location in Charlottesville

Sponsor: University of Virginia

Sex: All·Age: 18+

Code: NCT04977180·Phase 2·Recruiting·Listed Jul 2021

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Remotely Monitored Exercise Interventions in Patients With mCSPC Undergoing ADT (Prostate 006)

for Castrate Sensitive Prostate Cancer

1 location in Charlottesville

Sponsor: Paul Viscuse

Sex: Male·Age: 18+

Code: NCT06429813·Recruiting·Listed May 2024

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Sonodynamic Therapy in Patients With Recurrent GBM

for Recurrent Glioblastoma

1 location in Charlottesville

Sponsor: Shayan Moosa, MD

Sex: All·Age: 18 - 80

Code: NCT06039709·Phase 1·Recruiting·Listed Sep 2023

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Vaginal Cuff Brachytherapy Fractionation Study

for Endometrial Cancer

Sites in Charlottesville +2 more locations

Sponsor: Kara Romano, MD

Sex: Female·Age: 18+

Code: NCT03785288·Phase 3·Recruiting·Listed Dec 2018

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MOnaliZumab in Combination With durvAlumab (MEDI4736) for tRreatmenT of Small Cell Lung Cancer

for Small Cell Lung Cancer

Drug: Monalizumab

Sites in Charlottesville +3 more locations

Sponsor: Hirva Mamdani

Sex: All·Age: 18+

Code: NCT05903092·Phase 2·Recruiting·Listed Jun 2023

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Venetoclax, Lenalidomide and Rituximab in Patients With Previously Untreated Mantle Cell Lymphoma

for Mantle Cell Lymphoma

Drug: Venetoclax

Sites in Charlottesville +3 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT03523975·Phase 1, Phase 2·Recruiting·Listed May 2018

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A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation

for AML (Acute Myelogenous Leukemia)

Sites in Charlottesville +12 more locations

Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All·Age: 18 - 66

Code: NCT06859424·Phase 2·Recruiting·Listed Mar 2025

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Adagrasib + SRS for Patients With Metastatic KRAS G12C-mutated NSCLC With Untreated Brain Metastases

for Non Small Cell Lung Cancer

Drug: Adagrasib

Sites in Charlottesville, Richmond +1 more location

Sponsor: Ryan Gentzler, MD

Sex: All·Age: 18+

Code: NCT06248606·Phase 2·Recruiting·Listed Feb 2024

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A Trial of Robotic Versus Open Hysterectomy Surgery in Cervix Cancer

for Cervical Cancer

Sites in Charlottesville, Richmond +124 more locations

Sponsor: GOG Foundation

Sex: Female·Age: 18+

Code: NCT04831580·Recruiting·Listed Apr 2021

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Excision of Lymph Node Trial (EXCILYNT) (Mel69)

for Melanoma

Sites in Charlottesville +6 more locations

Sponsor: Craig L Slingluff, Jr

Sex: All·Age: 18+

Code: NCT05839912·Recruiting·Listed May 2023

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Adjuvant Chemoradiation and Biomarkers of Response in High-risk Breast Cancer

for Breast Cancer

1 location in Charlottesville

Sponsor: University of Virginia

Sex: All·Age: 18+

Code: NCT05288777·Phase 2, Phase 3·Recruiting·Listed Mar 2022

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Pre-Habilitation with Mindfulness and Exercise for Patients Undergoing Radical Cystectomy (PRIMER Trial)

for Bladder Cancer

1 location in Charlottesville

Sponsor: University of Virginia

Sex: All·Age: 18 - 90

Code: NCT05790850·Recruiting·Listed Mar 2023

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Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations

for Non-small Cell Lung Cancer (NSCLC)

Sites in Charlottesville, Fairfax +46 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07291037·Phase 3·Recruiting·Listed Dec 2025

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A Phase I, Open-label, Multicenter Study to Evaluate the Safety, Tolerability, Cellular Kinetics, Immunogenicity, Pharmacodynamics, and Preliminary Efficacy of AZD0120 in Participants With Multiple Myeloma (DURGA-2)

for Multiple Myeloma

Sites in Charlottesville +9 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07073547·Phase 1·Recruiting·Listed Jul 2025

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DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

for Endometrial Cancer

Drug: Rilvegostomig

Sites in Charlottesville, Fairfax +43 more locations

Sponsor: AstraZeneca

Sex: Female·Age: 18+

Code: NCT06989112·Phase 3·Recruiting·Listed May 2025

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A Phase 3 Study to Evaluate Petosemtamab Compared With Investigator's Choice Monotherapy in Previously Treated Head and Neck Squamous Cell Carcinoma Patients (LiGeR-HN2)

for Head and Neck Squamous Cell Carcinoma

Drug: Petosemtamab

Sites in Charlottesville, Winchester +59 more locations

Sponsor: Merus B.V.

Sex: All·Age: 18+

Code: NCT06496178·Phase 3·Recruiting·Listed Jul 2024

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A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)

for Breast Cancer

Drug: Durvalumab

Sites in Charlottesville, Midlothian +31 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06103864·Phase 3·Recruiting·Listed Oct 2023

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Study of Zanzalintinib in Combination With Immuno-Oncology Agents in Participants With Solid Tumors

for Renal Cell Carcinoma (RCC)

Sites in Charlottesville +43 more locations

Sponsor: Exelixis

Sex: All·Age: 18+

Code: NCT05176483·Phase 1·Recruiting·Listed Jan 2022

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A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer

for HER2-positive Gastric Cancer

Drug: Rilvegostomig

Sites in Charlottesville, Fairfax +43 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06764875·Phase 3·Recruiting·Listed Jan 2025

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Conditions in Oncology (Charlottesville, VA)

Non-small cell lung cancer (NSCLC)· 15 Solid tumor· 15 Acute myeloid leukemia (AML)· 11 Breast cancer· 10 Prostate cancer· 8 Metastatic prostate cancer· 8 Ovarian cancer· 8 Endometrial cancer· 6 Myelodysplastic syndromes (MDS)· 6 Pancreatic cancer· 5 Melanoma· 5 Cancer (any)· 5 Colorectal cancer· 4 Cervical cancer· 4 Glioblastoma· 4 Leukemia (other)· 4 Non-Hodgkin lymphoma· 4 Diffuse large B-cell lymphoma (DLBCL)· 4 Lung cancer· 3 Biliary tract cancer· 3 Bladder cancer· 3 Myelofibrosis· 3 Mantle cell lymphoma· 3 Hematologic malignancy· 3 Head and neck cancer· 3 Triple-negative breast cancer· 2 Small cell lung cancer· 2 Gastric cancer· 2 Fallopian tube cancer· 2 Glioma· 2 Multiple myeloma· 2 Myeloproliferative neoplasm· 2 Neuroendocrine tumors· 2 Metastatic breast cancer· 1 HER2-negative breast cancer· 1 Gastroesophageal junction cancer· 1 Liver cancer· 1 Kidney cancer· 1 Brain cancer· 1 Chronic lymphocytic leukemia (CLL)· 1 Acute lymphoblastic leukemia· 1 Hodgkin lymphoma· 1 Follicular lymphoma· 1 Marginal zone lymphoma· 1 Small lymphocytic lymphoma· 1 Osteosarcoma· 1 Ewing sarcoma· 1 Neuroblastoma· 1