A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Non-Small Cell Lung Cancer

Part of paid clinical trials in Los Angeles, California.

Sponsor
Verastem, Inc.
Study ID
NCT07659782
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • VS-7375 — DRUG
    Taken by mouth

Study Details

This study will assess the safety and efficacy of VS-7375 alone and in combination with cetuximab in patients with metastatic KRAS G12D - mutated Non-Small Cell Lung Cancer

Key Dates

First listed
Jun 22, 2026
Start date
Jul 22, 2026
Status verified
Jul 2026
Primary completion
Jun 30, 2027
Completion
Dec 31, 2028

Study Design

Enrollment
105 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: VS-7375 Monotherapy 2L/3L
    2L/3L VS-7375 dose
  • Experimental: VS-7375 Monotherapy 2L/3L Preferred Dose
    2L/3L Preferred VS-7375 dose
  • Experimental: 2L-4L with brain metastasis
    2L-4L VS-7375 dose

Primary Outcome Measure

Confirmed ORR by blinded independent central review (BICR) per RESIST v1.1 [ Time Frame: 6 months ]

Central Contacts

Locations (6)

FacilityCityStateZIPSite coordinators
START LALos AngelesCalifornia90025
Hope Team Distribution List
[email protected]
4244651820
Navid Hafez, MD (PRINCIPAL_INVESTIGATOR)
Valkyrie Clinical TrialsLos AngelesCalifornia90067
Matthew Nguyen
[email protected]
424 535 1874
David Berz, MD (PRINCIPAL_INVESTIGATOR)
Emory Winship Cancer InstituteAtlantaGeorgia30322
Lily Goggans
[email protected]
404-778-5087
Jennifer Carlisle, MD (PRINCIPAL_INVESTIGATOR)
START New JerseyEast BrunswickNew Jersey08816
Emily Lichtenstein
[email protected]
7324264750
Bruno Fang, MD (PRINCIPAL_INVESTIGATOR)
Memorial Sloan Kettering Cancer CenterNew YorkNew York10065
Robert Dyson
[email protected]
Kathryn Arbour, MD (PRINCIPAL_INVESTIGATOR)
START Fort WorthFort WorthTexas76104
Hope Team
[email protected]
6823503010
Salwan Almutar, MD (PRINCIPAL_INVESTIGATOR)

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START LA· Los Angeles, CAValkyrie Clinical Trials· Los Angeles, CAEmory Winship Cancer Institute· Atlanta, GASTART New Jersey· East Brunswick, NJMemorial Sloan Kettering Cancer Center· New York, NYSTART Fort Worth· Fort Worth, TX

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