Cardiology Clinical Trials in Chicago, IL

As of July 2026, 78 paid clinical trials are recruiting for Cardiology in Chicago, Illinois. Cardiology trials investigate SGLT-2 inhibitors, myosin modulators, lipid-lowering therapies, anti-inflammatory agents, and device-based interventions across heart failure, hypertension, AFib, and coronary artery disease. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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79 clinical trials for Cardiology

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BEETroot Juice to Reverse Functional Impairment in PAD

for Peripheral Artery Disease

Sites in Chicago +2 more locations

Sponsor: Northwestern University

Sex: All·Age: 50+

Code: NCT05624125·Recruiting·Listed Nov 2022

Apply to this trial

HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets

for Heart Failure

Sites in Chicago +5 more locations

Sponsor: Northwestern University

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT05873634·Recruiting·Listed May 2023

Apply to this trial

Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction

for Heart Failure

Sites in Chicago +5 more locations

Sponsor: Northwestern University

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT06517186·Recruiting·Listed Jul 2024

Apply to this trial

Community-based Approach to Lowering Stress Through Mindfulness

for Depression

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT06987799·Recruiting·Listed May 2025

Apply to this trial

Fisetin to Reduce Senescence and Mobility Impairment in PAD

for Peripheral Arterial Disease

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 50+

Code: NCT06399809·Phase 2·Recruiting·Listed May 2024

Apply to this trial

ENhancing Exercise With LIGHT to Improve Functioning in PAD

for Peripheral Artery Disease

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 50+

Code: NCT06399900·Recruiting·Listed May 2024

Apply to this trial

SMART Exercise for PAD

for Peripheral Arterial Disease

Sites in Chicago +2 more locations

Sponsor: Northwestern University

Sex: All·Age: 50+

Code: NCT06032065·Phase 3·Recruiting·Listed Sep 2023

Apply to this trial

Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk

for Peripheral Arterial Disease

Sites in Chicago +18 more locations

Sponsor: Population Health Research Institute

Sex: All·Age: 18+

Code: NCT04774159·Phase 3·Recruiting·Listed Mar 2021

Apply to this trial

Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

for Diabetic Nephropathies

Drug: Sotagliflozin

Sites in Chicago +12 more locations

Sponsor: Alessandro Doria

Sex: All·Age: 18 - 75

Code: NCT06217302·Phase 3·Recruiting·Listed Jan 2024

Apply to this trial

His-Bundle Corrective Pacing in Heart Failure

for Right Bundle-Branch Block

Sites in Chicago +13 more locations

Sponsor: University of Rochester

Sex: All·Age: 18+

Code: NCT05265520·Recruiting·Listed Mar 2022

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The 1200 Patients Project: Studying the Implementation of Clinical Pharmacogenomic Testing

for Patients Undergoing Routine Health Care

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT01280825·Recruiting·Listed Jan 2011

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Prevention of Postoperative Atrial Fibrillation (POAF) Using Intra-Pericardial Amiodarone

for Atrial Fibrillation

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 20 - 85

Code: NCT06063538·EARLY_Phase 1·Recruiting·Listed Oct 2023

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Effect of Dapagliflozin on Metabolomics and Cardiac Mechanics in Chronic Kidney Disease

for Chronic Kidney Diseases

Drug: Dapagliflozin

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 85

Code: NCT05719714·Phase 1, Phase 2·Recruiting·Listed Feb 2023

Apply to this trial

Diabetic Neuropathy in Spinal Cord Stimulator Patients

for Diabetes Mellitus

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT04687215·Recruiting·Listed Dec 2020

Apply to this trial

Human/Machine Interface: What the HeartMate 3 ® Device Tells Us About the Future

for LVAD

Sites in Chicago +3 more locations

Sponsor: International Consortium of Circulatory Assist Clinicians

Sex: All·Age: 18 - 100

Code: NCT06039176·Recruiting·Listed Sep 2023

Apply to this trial

iCardia4HF: Multi-component mHealth Intervention for Patients With Heart Failure

for Heart Failure

2 locations in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT06205225·Recruiting·Listed Jan 2024

Apply to this trial

Left vs Left Randomized Clinical Trial

for Heart Failure

Sites in Chicago, Evanston +55 more locations

Sponsor: Baylor College of Medicine

Sex: All·Age: 18+

Code: NCT05650658·Recruiting·Listed Dec 2022

Apply to this trial

UIC Multi-Ethnic DCM Registry

for Heart Failure

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07145138·Recruiting·Listed Aug 2025

Apply to this trial

Implementing Models for Mechanical Circulatory Support Presurgical Assessment in Congenital Heart Disease Treatment

for Congenital Heart Disease

Sites in Chicago +4 more locations

Sponsor: Columbia University

Sex: All·Age: All ages

Code: NCT03891160·Recruiting·Listed Mar 2019

Apply to this trial

Semaglutide for Metabolic Intervention and Adipose Loss to Treat Atrial Fibrillation

for Overweight or Obesity

Drug: Semaglutide

Sites in Chicago +1 more location

Sponsor: University of Chicago

Sex: All·Age: 18 - 75

Code: NCT06499857·Phase 3·Recruiting·Listed Jul 2024

Apply to this trial

Community Intervention to Reduce CardiovascuLar Disease in Chicago

for Hypertension

3 locations in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 89

Code: NCT04755153·Recruiting·Listed Feb 2021

Apply to this trial

Improving Mobility After Revascularization in Peripheral Artery Disease

for Peripheral Artery Disease

Sites in Chicago +6 more locations

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT06686121·Phase 3·Recruiting·Listed Nov 2024

Apply to this trial

Response to Exercise and Nitric Oxide in PAD

for Peripheral Artery Disease

2 locations in Chicago

Sponsor: Northwestern University

Sex: All·Age: 50+

Code: NCT06657976·Phase 2·Recruiting·Listed Oct 2024

Apply to this trial

Role of Adiposomes in Endothelial Dysfunction

for Obesity

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 50

Code: NCT05199454·Recruiting·Listed Jan 2022

Apply to this trial

MANAGE-AF Registry -MANAGEment of Atrial Fibrillation Outcomes Registry (MANAGE-AF)

for Atrial Fibrillation

1 location in Chicago

Sponsor: CorVita Science Foundation

Sex: All·Age: 18+

Code: NCT05978466·Recruiting·Listed Aug 2023

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Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement

for Aortic Stenosis

Sites in Chicago +54 more locations

Sponsor: University of British Columbia

Sex: All·Age: All ages

Code: NCT04634240·Recruiting·Listed Nov 2020

Apply to this trial

Preparing FIM-BCS - A Lifestyle Modification for African-American Breast Cancer Survivors

for Hypertension

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: Female·Age: 18 - 99

Code: NCT06504914·Recruiting·Listed Jul 2024

Apply to this trial

Use of Bedside Imaging and Community Health Workers for Early Screening and Referral of Pre-symptomatic Stage B Heart Failure in the Emergency Department

for Heart Diseases

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 45+·Accepts healthy volunteers

Code: NCT06769880·Recruiting·Listed Jan 2025

Apply to this trial

Intensive Patient Referral and Education Program Prior to Renal Replacement Therapy

for Chronic Kidney Disease

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 70

Code: NCT06397456·Recruiting·Listed May 2024

Apply to this trial

TEXT4HF: A Randomized Controlled Trial of a Tailored Text Messaging Intervention to Improve Self-Care in Older Adult Patients With Heart Failure

for Heart Failure

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 50+

Code: NCT06473532·Recruiting·Listed Jun 2024

Apply to this trial

Pharmacogenetic Study of Antiarrhythmic Drugs for Atrial Fibrillation

for Atrial Fibrillation

Sites in Chicago & Oak Lawn

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 100

Code: NCT02347111·Phase 4·Recruiting·Listed Jan 2015

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Cardiac Power Output in Cardiogenic Shock Patients

for Heart Failure

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT05700617·EARLY_Phase 1·Recruiting·Listed Jan 2023

Apply to this trial

Interactive Computer-adaptive Chronic Kidney Disease Education Program

for Chronic Kidney Diseases

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 70

Code: NCT06364358·Recruiting·Listed Apr 2024

Apply to this trial

FIM+DASH: Food is Medicine Intervention to Promote Healthy Eating and Blood Pressure Control

for Hypertension

4 locations in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: All ages

Code: NCT07332741·Phase 2·Recruiting·Listed Jan 2026

Apply to this trial

A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event

for Cardiovascular Disease

Sites in Chicago, Melrose Park +294 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07000357·Phase 3·Recruiting·Listed Jun 2025

Apply to this trial

Product Surveillance Registry

for Cardiac Rhythm Disorders

Sites in Chicago +128 more locations

Sponsor: Medtronic

Sex: All·Age: All ages

Code: NCT01524276·Recruiting·Listed Feb 2012

Apply to this trial

Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

for Heart Failure

Drug: Dapagliflozin

Sites in Chicago, Park Ridge +172 more locations

Sponsor: AstraZeneca

Sex: All·Age: 40+

Code: NCT06677060·Phase 3·Recruiting·Listed Nov 2024

Apply to this trial

LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF

for Pulmonary Hypertension

Sites in Chicago, Galesburg +39 more locations

Sponsor: Tenax Therapeutics, Inc.

Sex: All·Age: 18 - 85

Code: NCT05983250·Phase 3·Recruiting·Listed Aug 2023

Apply to this trial

Conditions in Cardiology (Chicago, IL)

Heart failure· 29 Hypertension (high blood pressure)· 23 Cardiovascular disease (general)· 16 Atrial fibrillation· 11 Peripheral artery disease· 10 Pulmonary hypertension· 6 Coronary artery disease· 5 Congenital heart disease· 2