GI oncology Clinical Trials in Chicago, IL

As of September 2026, 56 paid clinical trials are recruiting for GI oncology in Chicago, Illinois. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 1, 2026.

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57 clinical trials for GI oncology

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Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer

for Colorectal Cancer

Sites in Chicago, Ottawa +140 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 60+

Code: NCT03998202·Recruiting·Listed Jun 2019

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Exogenous and Endogenous Risk Factors for Early-onset Colorectal Cancer

for Colorectal Cancer

Sites in Chicago +1 more location

Sponsor: San Raffaele University

Sex: All·Age: 18 - 49·Accepts healthy volunteers

Code: NCT05732623·Recruiting·Listed Feb 2023

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FITting Non-invasive Tests in Lynch Syndrome Surveillance

for Colorectal Cancer

Sites in Chicago +2 more locations

Sponsor: University of Chicago

Sex: All·Age: 20 - 80

Code: NCT06898996·Recruiting·Listed Mar 2025

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Surveillance vs. Endoscopic Therapy for Barrett's Esophagus With Low-grade Dysplasia

for Barretts Esophagus With Dysplasia

Sites in Chicago +22 more locations

Sponsor: University of Colorado, Denver

Sex: All·Age: 18 - 89

Code: NCT05753748·Recruiting·Listed Mar 2023

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Seattle Biopsy Protocol Versus Wide-Area Transepithelial Sampling in Patients With Barrett's Esophagus Undergoing Surveillance

for Barrett Esophagus

Sites in Chicago +13 more locations

Sponsor: University of Colorado, Denver

Sex: All·Age: 18 - 89

Code: NCT05530343·Recruiting·Listed Sep 2022

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Manipulation of the Gut Microbiome by a Standardized Preoperative Diet to Prevent Colorectal Cancer Recurrence and Metastasis Following Surgery

for Colorectal Cancer

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT06349590·Phase 1, Phase 2·Recruiting·Listed Apr 2024

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The Dragon PLC Trial (DRAGON-PLC)

for Primary Liver Cancer

Sites in Chicago +4 more locations

Sponsor: Maastricht University

Sex: All·Age: 18+

Code: NCT06914648·Recruiting·Listed Apr 2025

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TREAT-BE Study (Treatment With Resection and Endoscopic Ablation Techniques for Barrett's Esophagus)

for Barrett's Esophagus

Sites in Chicago +3 more locations

Sponsor: University of Colorado, Denver

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT02634645·Recruiting·Listed Dec 2015

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Safety of Combining Irinotecan With 5-FU, Leucovorin/Folinic Acid, Oxaliplatin, and Docetaxel Chemotherapies

for Pancreatic Adenocarcinoma

Drug: Irinotecan

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT04361708·Phase 1·Recruiting·Listed Apr 2020

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Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2

for Gastric Cancer

Drug: Sonesitatug vedotin

Sites in Chicago, Niles +70 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07431281·Phase 3·Recruiting·Listed Feb 2026

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A Study of Rilvegostomig or Durvalumab Plus Chemotherapy for First-Line Treatment of Biliary Tract Cancer (ARTEMIDE-Biliary02)

for Biliary Tract Cancer

Drug: Rilvegostomig

Sites in Chicago +35 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07221253·Phase 3·Recruiting·Listed Oct 2025

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Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors

for Non-small Cell Lung Cancer

Sites in Chicago +17 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06218914·Phase 1·Recruiting·Listed Jan 2024

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A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer

for Metastatic Colorectal Cancer

Sites in Chicago +10 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06792695·Phase 2·Recruiting·Listed Jan 2025

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Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer

for Biliary Tract Cancer

Drug: Rilvegostomig

Sites in Chicago, Niles +29 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 99

Code: NCT06467357·Phase 3·Recruiting·Listed Jun 2024

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Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma

for Hepatocellular Carcinoma

Drug: Rilvegostomig

Sites in Chicago +30 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06921785·Phase 3·Recruiting·Listed Apr 2025

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A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer

for HER2-positive Gastric Cancer

Drug: Rilvegostomig

Sites in Chicago, Hinsdale +43 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06764875·Phase 3·Recruiting·Listed Jan 2025

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Conditions in GI oncology (Chicago, IL)

Colorectal cancer· 15 Pancreatic cancer· 11 Gastric cancer· 11 Esophageal cancer· 10 Gastroesophageal junction cancer· 7 Biliary tract cancer· 7 Liver cancer· 5 Metastatic colorectal cancer· 3 Rectal cancer· 2 Colon cancer· 1 Gastrointestinal cancer· 1