Clinical Trials at Cleveland Clinic

As of July 2026, 345 paid clinical trials are recruiting at Cleveland Clinic, located at Cleveland Clinic Mellen Center, 1950 E 89th St U Bldg, Cleveland, OH 44195, phone (216) 444-8600 in Cleveland, Ohio. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 13, 2026.

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345 clinical trials at Cleveland Clinic

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REMASTer: REcurrent Brain Metastases After SRS Trial

for Brain Metastases

9 locations incl. Los Angeles

Sponsor: Monteris Medical

Sex: All·Age: 18+

Code: NCT05124912·Recruiting

Apply to this trial

Phase 1/2 Study of Intratumoral Injection of STX-001 in Advanced Solid Tumors as Monotherapy or in Combination With Pembrolizumab

for Advanced Solid Tumor

6 locations incl. Scottsdale

Sponsor: Strand Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06249048·Phase 1, Phase 2·Recruiting

Apply to this trial

Single and Multiple Dose Escalation of PHIN-214 in Child-Pugh A and B Liver Cirrhotics

for Cirrhosis, Liver

9 locations incl. Chandler

Sponsor: PharmaIN

Sex: All·Age: 18 - 75

Code: NCT05490888·Phase 1·Recruiting

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Study of HQP1351 in Subjects With Refractory CML and Ph+ ALL

for Leukemia, Myeloid, Chronic

8 locations incl. Birmingham

Sponsor: Ascentage Pharma Group Inc.

Sex: All·Age: 18+

Code: NCT04260022·Phase 1·Recruiting

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STimulation to Activate RespIration

for ARDS (Moderate or Severe)

6 locations incl. La Jolla

Sponsor: Lungpacer Medical Inc.

Sex: All·Age: 18+

Code: NCT06832306·Recruiting

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Study of APG-2575 as a Single Agent or in Combination With Other Therapeutic Agents for CLL/SLL

for CLL/SLL

7 locations incl. Duarte

Sponsor: Ascentage Pharma Group Inc.

Sex: All·Age: 18 - 85

Code: NCT04215809·Phase 1·Recruiting

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A Multicenter, Postmarket Surveillance Study of Subjects With the Canary canturioTM te Tibial Extension

for Knee Osteoarthritis

7 locations incl. Fayetteville

Sponsor: Canary Medical

Sex: All·Age: 18+

Code: NCT06040827·Recruiting

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Safety and Efficacy of the VERTICA® RF Device for the Treatment of ED

for Erectile Dysfunction

7 locations incl. Newport Beach

Sponsor: OHH-MED Medical Ltd

Sex: Male·Age: 22 - 85·Accepts healthy volunteers

Code: NCT06167733·Recruiting

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KQB198 in Combination With Imatinib in Participants With Advanced/Metastatic GIST in 1st Line Setting (SynerGIST-1st Line)

for GIST - Gastrointestinal Stromal Tumor

16 locations incl. Los Angeles

Sponsor: Kumquat Biosciences Inc.

Sex: All·Age: 18+

Code: NCT07406633·Phase 2·Recruiting

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Testing of GripTract-GI Endoscopic Tissue Manipulator for Use During Complex Endoscopic Polypectomies in the Colon

for Polyps Colorectal

1 location in Cleveland

Sponsor: Actuated Medical, Inc.

Sex: All·Age: 21+

Code: NCT06015607·Recruiting

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Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Breast Cancer w/Liver Dominant Disease

for Metastatic Breast Cancer in the Liver

4 locations incl. Tampa

Sponsor: Delcath Systems Inc.

Sex: All·Age: 18+

Code: NCT06875128·Phase 2·Recruiting

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A Study to Evaluate Efficacy and Safety of Ciltacabtagene Autoleucel

for Multiple Myeloma

5 locations incl. San Francisco

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18 - 80

Code: NCT07149857·Phase 2·Recruiting

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A Phase I/II, Open-label Study to Investigate the Safety, Tolerability, PK, and Preliminary Efficacy of FB849

for Advanced Solid Tumor

5 locations incl. Cleveland

Sponsor: 1ST Biotherapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05761223·Phase 1, Phase 2·Recruiting

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A Post-market, Real-world Experience: Expanding Access to Care by Incorporating the Symani® Surgical System and Enabling Surgeons

for Open Surgery

4 locations incl. Beverly Hills

Sponsor: MMI (Medical Microinstruments, Inc.)

Sex: All·Age: 22+

Code: NCT06725030·Recruiting

Apply to this trial

Safety of HRX215 in Patients After Minor and Major Liver Resection

for Liver Resection

3 locations incl. Baltimore

Sponsor: HepaRegeniX GmbH

Sex: All·Age: 18 - 75

Code: NCT06638502·Phase 1, Phase 2·Recruiting

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APrevent-VOIS-Implant-002 - a Two-Part, Open-Label, Non-Randomized Multicenter Study

for Paralysis, Unilateral, Vocal Cord

4 locations incl. Phoenix

Sponsor: APrevent Biotech GmbH

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT05119842·Recruiting

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CardiAMP Heart Failure II Trial for Patients With Ischemic Heart Failure With Reduced Ejection Fraction

for Ischemic Heart Failure

5 locations incl. Clearwater

Sponsor: BioCardia, Inc.

Sex: All·Age: 21 - 90

Code: NCT06258447·Recruiting

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RESET System Pivotal Trial (Rev F)

for Diabetes type2

7 locations incl. Washington D.C.

Sponsor: Morphic Medical Inc.

Sex: All·Age: 22 - 65

Code: NCT04101669·Recruiting

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CORCYM Mitral, Aortic aNd Tricuspid Post-maRket Study in a reAl-world Setting

for Cardiac Valve Disease

9 locations incl. Indianapolis

Sponsor: Corcym S.r.l

Sex: All·Age: All ages

Code: NCT05002543·Recruiting

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Phase 2 Study for the Patient, Who Has Diagnosed With Small Cell Lung Cancer (SCLC) or Non Small Cell Lung Cancer (NSCLC) or Renal Cell Carcinoma (RCC) and Finished the First Line Stand Treatment , Need More Treatment

for Small Cell Lung Cancer

5 locations incl. Birmingham

Sponsor: Advenchen Pharmaceuticals, LLC.

Sex: All·Age: 18+

Code: NCT05363280·Phase 2·Recruiting

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PARADIGM - En Bloc Trial With the EndoQuest Endoluminal Surgical (ELS) System

for Colorectal Lesion

6 locations incl. Scottsdale

Sponsor: EndoQuest Robotics, Inc.

Sex: All·Age: 22+

Code: NCT06133387·Recruiting

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Evaluation of Cochlear (Promontory) Stimulation During Awake Ear Surgery (TONES Study)

for Hearing Disorder

1 location in Cleveland

Sponsor: Auricle Health Inc.

Sex: All·Age: 18+

Code: NCT07402941·Recruiting

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CEM-Plate and CEM-Cage First-In-Human Use Efficacy Study

for Neck Pain

4 locations incl. Union

Sponsor: ReVivo Medical, Corp.

Sex: All·Age: 22 - 79

Code: NCT04883411·Recruiting

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Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)

for Arrhythmogenic Right Ventricular Cardiomyopathy

8 locations incl. San Francisco

Sponsor: Tenaya Therapeutics

Sex: All·Age: 14 - 65

Code: NCT06311708·Recruiting

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Spartan Stem, World Cup and World Liner Post Market Clinical Follow-up Study

for Hip Replacement

1 location in Cleveland

Sponsor: Signature Orthopaedics

Sex: All·Age: 18 - 75

Code: NCT06172569·Recruiting

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Everglade Stem, World Cup and World Liner Post Market Clinical Follow-up

for Hip Disease

1 location in Cleveland

Sponsor: Signature Orthopaedics

Sex: All·Age: 18 - 75

Code: NCT06153940·Recruiting

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Physiologic Signals and Signatures With the Accuryn Monitoring System - The Accuryn Registry

for Intraabdominal Hypertension

9 locations incl. Los Angeles

Sponsor: Potrero Medical

Sex: All·Age: 18+

Code: NCT04669548·Recruiting

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Pounce™ Thrombectomy System Retrospective Registry

for Peripheral Arterial Disease

9 locations incl. Peoria

Sponsor: SurModics, Inc.

Sex: All·Age: 18+

Code: NCT05868161·Recruiting

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A Registry of Cardiac PET and CardioFlux Magnetocardiography in Patients With Suspected Coronary Ischemia.

for Coronary

2 locations incl. Cleveland

Sponsor: Genetesis Inc.

Sex: All·Age: 40+

Code: NCT05868902·Recruiting

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Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults With PKP2 Mutation-associated ARVC

for Arrhythmogenic Right Ventricular Cardiomyopathy

7 locations incl. San Francisco

Sponsor: Tenaya Therapeutics

Sex: All·Age: 18 - 65

Code: NCT06228924·Phase 1·Recruiting

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Trisol System EFS Study

for Tricuspid Regurgitation

7 locations incl. Los Angeles

Sponsor: Trisol Medical

Sex: All·Age: 18+

Code: NCT04905017·Recruiting

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A Study to Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Conventional Anti-cancer Drugs, Pembrolizumab or Trastuzumab Deruxtecan(T-DXd) in Patients with Advanced Solid Tumors (KEYNOTE-G08)

for Advanced Solid Tumor

5 locations incl. Scottsdale

Sponsor: GI Innovation, Inc.

Sex: All·Age: 18+

Code: NCT05824975·Phase 1, Phase 2·Recruiting

Apply to this trial

A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

for Hematologic Malignancies

142 locations incl. Birmingham

Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All·Age: All ages

Code: NCT01351545·Recruiting

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Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

for Intracerebral Hemorrhage

187 locations incl. Birmingham

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT03907046·Phase 3·Recruiting

Apply to this trial

HEALEY ALS Platform Trial - Master Protocol

for Amyotrophic Lateral Sclerosis

81 locations incl. Phoenix

Sponsor: Merit E. Cudkowicz, MD

Sex: All·Age: 18+

Code: NCT04297683·Phase 2, Phase 3·Recruiting

Apply to this trial

The Fourth Left Atrial Appendage Occlusion Study

for Atrial Fibrillation

51 locations incl. Birmingham

Sponsor: Hamilton Health Sciences Corporation

Sex: All·Age: 18+

Code: NCT05963698·Recruiting

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Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Prospective Outcomes Registry

for Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease

44 locations incl. Birmingham

Sponsor: Duke University

Sex: All·Age: 21+

Code: NCT01915511·Recruiting

Apply to this trial

Left vs Left Randomized Clinical Trial

for Heart Failure

57 locations incl. Gilbert

Sponsor: Baylor College of Medicine

Sex: All·Age: 18+

Code: NCT05650658·Recruiting

Apply to this trial

Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort

for Huntington's Disease

62 locations incl. Birmingham

Sponsor: CHDI Foundation, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT01574053·Recruiting

Apply to this trial

Gastroschisis Outcomes of Delivery (GOOD) Study

for Gastroschisis

38 locations incl. Phoenix

Sponsor: Medical College of Wisconsin

Sex: Female·Age: 18+

Code: NCT02774746·Recruiting

Apply to this trial