Clinical Trials at Cleveland Clinic

As of August 2026, 320 paid clinical trials are recruiting at Cleveland Clinic, located at 9500 EUCLID AVE # C21, CLEVELAND, OH 44195-0001, phone (216) 444-0522 in Cleveland, Ohio. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 27, 2026.

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322 clinical trials at Cleveland Clinic

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CEM-Plate and CEM-Cage First-In-Human Use Efficacy Study

for Neck Pain

Sites in Cleveland +3 more locations

Sponsor: ReVivo Medical, Corp.

Sex: All·Age: 22 - 79

Code: NCT04883411·Recruiting·Listed May 2021

Apply to this trial

A Multicenter, Postmarket Surveillance Study of Subjects With the Canary canturioTM te Tibial Extension

for Knee Osteoarthritis

Sites in Cleveland, New Albany +5 more locations

Sponsor: Canary Medical

Sex: All·Age: 18+

Code: NCT06040827·Recruiting·Listed Sep 2023

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Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)

for Arrhythmogenic Right Ventricular Cardiomyopathy

Sites in Cleveland +7 more locations

Sponsor: Tenaya Therapeutics

Sex: All·Age: 14 - 65

Code: NCT06311708·Recruiting·Listed Mar 2024

Apply to this trial

Spartan Stem, World Cup and World Liner Post Market Clinical Follow-up Study

for Hip Replacement

1 location in Cleveland

Sponsor: Signature Orthopaedics

Sex: All·Age: 18 - 75

Code: NCT06172569·Recruiting·Listed Dec 2023

Apply to this trial

Everglade Stem, World Cup and World Liner Post Market Clinical Follow-up

for Hip Disease

1 location in Cleveland

Sponsor: Signature Orthopaedics

Sex: All·Age: 18 - 75

Code: NCT06153940·Recruiting·Listed Dec 2023

Apply to this trial

Physiologic Signals and Signatures With the Accuryn Monitoring System - The Accuryn Registry

for Intraabdominal Hypertension

Sites in Cleveland +5 more locations

Sponsor: Potrero Medical

Sex: All·Age: 18+

Code: NCT04669548·Recruiting·Listed Dec 2020

Apply to this trial

Validation of Donor-Derived Cell-Free DNA (Dd-cfDNA) for Kidney Transplant Monitoring

for Kidney Transplant Rejection

Sites in Cleveland +5 more locations

Sponsor: Insight Molecular Diagnostics

Sex: All·Age: 18+

Code: NCT07060716·Recruiting·Listed Jul 2025

Apply to this trial

Single and Multiple Dose Escalation of PHIN-214 in Child-Pugh A and B Liver Cirrhotics

for Cirrhosis, Liver

Sites in Cleveland +8 more locations

Sponsor: PharmaIN

Sex: All·Age: 18 - 75

Code: NCT05490888·Phase 1·Recruiting·Listed Aug 2022

Apply to this trial

Study of APG-2575 as a Single Agent or in Combination With Other Therapeutic Agents for CLL/SLL

for CLL/SLL

Sites in Cleveland, Canton +5 more locations

Sponsor: Ascentage Pharma Group Inc.

Sex: All·Age: 18 - 85

Code: NCT04215809·Phase 1·Recruiting·Listed Jan 2020

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Pounce™ Thrombectomy System Retrospective Registry

for Peripheral Arterial Disease

Sites in Cleveland +6 more locations

Sponsor: SurModics, Inc.

Sex: All·Age: 18+

Code: NCT05868161·Recruiting·Listed May 2023

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A Phase I/II, Open-label Study to Investigate the Safety, Tolerability, PK, and Preliminary Efficacy of FB849

for Advanced Solid Tumor

Sites in Cleveland +4 more locations

Sponsor: 1ST Biotherapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05761223·Phase 1, Phase 2·Recruiting·Listed Mar 2023

Apply to this trial

APrevent-VOIS-Implant-002 - a Two-Part, Open-Label, Non-Randomized Multicenter Study

for Paralysis, Unilateral, Vocal Cord

Sites in Cleveland +3 more locations

Sponsor: APrevent Biotech GmbH

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT05119842·Recruiting·Listed Nov 2021

Apply to this trial

RESET System Pivotal Trial (Rev F)

for Diabetes type2

Sites in Cleveland +6 more locations

Sponsor: Morphic Medical Inc.

Sex: All·Age: 22 - 65

Code: NCT04101669·Recruiting·Listed Sep 2019

Apply to this trial

Trisol System EFS Study

for Tricuspid Regurgitation

Sites in Cleveland +6 more locations

Sponsor: Trisol Medical

Sex: All·Age: 18+

Code: NCT04905017·Recruiting·Listed May 2021

Apply to this trial

A Registry of Cardiac PET and CardioFlux Magnetocardiography in Patients With Suspected Coronary Ischemia.

for Coronary

Sites in Cleveland & Kettering

Sponsor: Genetesis Inc.

Sex: All·Age: 40+

Code: NCT05868902·Recruiting·Listed May 2023

Apply to this trial

CORCYM Mitral, Aortic aNd Tricuspid Post-maRket Study in a reAl-world Setting

for Cardiac Valve Disease

Sites in Cleveland +6 more locations

Sponsor: Corcym S.r.l

Sex: All·Age: All ages

Code: NCT05002543·Recruiting·Listed Aug 2021

Apply to this trial

A Study to Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Conventional Anti-cancer Drugs, Pembrolizumab or Trastuzumab Deruxtecan(T-DXd) in Patients with Advanced Solid Tumors (KEYNOTE-G08)

for Advanced Solid Tumor

Sites in Cleveland +4 more locations

Sponsor: GI Innovation, Inc.

Sex: All·Age: 18+

Code: NCT05824975·Phase 1, Phase 2·Recruiting·Listed Apr 2023

Apply to this trial

Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults With PKP2 Mutation-associated ARVC

for Arrhythmogenic Right Ventricular Cardiomyopathy

Sites in Cleveland +6 more locations

Sponsor: Tenaya Therapeutics

Sex: All·Age: 18 - 65

Code: NCT06228924·Phase 1·Recruiting·Listed Jan 2024

Apply to this trial

Wearable Technology in Heart Failure Patients

for Heart Failure

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 85

Code: NCT07650669·Recruiting·Listed Jun 2026

Apply to this trial

Health-Related Quality of Life and Metabolic Outcomes in PCOS

for PCOS (Polycystic Ovary Syndrome)

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: Female·Age: 18 - 49·Accepts healthy volunteers

Code: NCT07571915·Recruiting·Listed May 2026

Apply to this trial

Centered Surgery - Preoperative Counseling and Patient Satisfaction

for Pelvic Organ Prolapse

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT07471464·Recruiting·Listed Mar 2026

Apply to this trial

Humidity Asthma Interventions for Low Socioeconomic Status Children

for Pediatric Asthma

2 locations in Cleveland

Sponsor: Case Western Reserve University

Sex: All·Age: Up to 18

Code: NCT07453667·Recruiting·Listed Mar 2026

Apply to this trial

Bridging the Gap: Educating Patients on Social Determinants of Health to Improve Epilepsy Surgery Access and Outcomes

for Epilepsy

1 location in Cleveland

Sponsor: Anny Reyes

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07509190·Recruiting·Listed Apr 2026

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Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study

for Hypertension

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: Female·Age: 18+

Code: NCT07363343·Recruiting·Listed Jan 2026

Apply to this trial

Bowel Continence Across the Lifespan in People With Spina Bifida

for Spina Bifida

Sites in Cleveland, Columbus +22 more locations

Sponsor: David Chu

Sex: All·Age: 5+

Code: NCT07390318·Recruiting·Listed Feb 2026

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Metabolic Impacts of Ren-Nu: A Dietary Program for Polycystic Kidney Disease

for Autosomal Dominant Polycystic Kidney Disease (ADPKD)

1 location in Cleveland

Sponsor: Richard Fatica

Sex: All·Age: 18+

Code: NCT07454174·Recruiting·Listed Mar 2026

Apply to this trial

Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy

for Peripartum Cardiomyopathy, Postpartum

Sites in Cleveland +60 more locations

Sponsor: Dennis M. McNamara, MD, MS

Sex: Female·Age: 18+

Code: NCT05180773·Phase 4·Recruiting·Listed Jan 2022

Apply to this trial

Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Prospective Outcomes Registry

for Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease

Sites in Cleveland, Columbus +37 more locations

Sponsor: Duke University

Sex: All·Age: 21+

Code: NCT01915511·Recruiting·Listed Aug 2013

Apply to this trial

Abatacept in Immune Checkpoint Inhibitor Myocarditis

for Myocarditis Acute

Sites in Cleveland +28 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05335928·Phase 3·Recruiting·Listed Apr 2022

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A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

for Glioblastoma

Sites in Cleveland +20 more locations

Sponsor: Global Coalition for Adaptive Research

Sex: All·Age: 18+

Code: NCT03970447·Phase 2, Phase 3·Recruiting·Listed May 2019

Apply to this trial

A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

for Hematologic Malignancies

Sites in Cleveland, Akron +111 more locations

Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All·Age: All ages

Code: NCT01351545·Recruiting·Listed May 2011

Apply to this trial

Multi-Center Clean Air Randomized Controlled Trial in COPD

for Chronic Obstructive Pulmonary Disease (COPD)

Sites in Cleveland +10 more locations

Sponsor: JHSPH Center for Clinical Trials

Sex: All·Age: 40+

Code: NCT06376994·Phase 3·Recruiting·Listed Apr 2024

Apply to this trial

Integrated Therapies for Alcohol Use in Alcohol-associated Liver Disease (ITAALD) Trial

for Alcohol-associated Hepatitis

Sites in Cleveland +5 more locations

Sponsor: Samer Gawrieh

Sex: All·Age: 18 - 70

Code: NCT07060638·Phase 2·Recruiting·Listed Jul 2025

Apply to this trial

The Fourth Left Atrial Appendage Occlusion Study

for Atrial Fibrillation

Sites in Cleveland, Canton +45 more locations

Sponsor: Hamilton Health Sciences Corporation

Sex: All·Age: 18+

Code: NCT05963698·Recruiting·Listed Jul 2023

Apply to this trial

Fibrosis Lessens After Metabolic Surgery

for Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD)

Sites in Cleveland +3 more locations

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06374875·Phase 4·Recruiting·Listed Apr 2024

Apply to this trial

Abatacept for the Treatment of Giant Cell Arteritis

for Giant Cell Arteritis

Sites in Cleveland +4 more locations

Sponsor: University of Pennsylvania

Sex: All·Age: 50+

Code: NCT04474847·Phase 3·Recruiting·Listed Jul 2020

Apply to this trial

Personalized Real-Time DBS and PD Mechanisms

for Parkinson Disease

1 location in Cleveland

Sponsor: David Escobar

Sex: All·Age: 18 - 80

Code: NCT06013956·Phase 4·Recruiting·Listed Aug 2023

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Treatment of Antibody-Mediated Rejection (ABMR) With CarBel

for Kidney Transplant Rejection

Sites in Cleveland, Cincinnati +9 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 75

Code: NCT06918990·Phase 1·Recruiting·Listed Apr 2025

Apply to this trial

Genetic Testing to Select Therapy for the Treatment of Advanced or Metastatic Kidney Cancer, OPTIC RCC Study

for Advanced Clear Cell Renal Cell Carcinoma

Sites in Cleveland +5 more locations

Sponsor: Vanderbilt-Ingram Cancer Center

Sex: All·Age: 18+

Code: NCT05361720·Phase 2·Recruiting·Listed May 2022

Apply to this trial

Robotic Versus Open Ventral Hernia Repair

for Ventral Hernia

Sites in Cleveland +4 more locations

Sponsor: Lucas Beffa

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05472987·Recruiting·Listed Jul 2022

Apply to this trial