Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study

Part of paid clinical trials in Cleveland, Ohio.

Sponsor
The Cleveland Clinic
Study ID
NCT07363343
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
FEMALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Nifedipine and Enalapril — DRUG
    Nifedipine 60mg by mouth every twelve hours plus Enalapril 5mg by mouth every twelve hours
  • Nifedipine and Labetalol — DRUG
    Nifedipine 60mg by mouth every twelve hours plus Labetalol 200mg by mouth every twelve hours

Study Details

To determine if nifedipine and enalapril will have better blood pressure control in the postpartum setting compared to nifedipine and labetalol.

Key Dates

Start date
Mar 10, 2026
Status verified
Jun 2026
Primary completion
Dec 31, 2029
Completion
Dec 31, 2029

Study Design

Enrollment
200 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Nifedipine and Enalapril
    Nifedipine 60mg by mouth every twelve hours plus Enalapril 5mg by mouth every twelve hours
  • Active Comparator: Nifedipine and Labetalol
    Nifedipine 60mg by mouth every twelve hours plus Labetalol 200mg by mouth every twelve hours

Primary Outcome Measure

Composite postpartum hypertension treatment failure within 6 weeks postpartum [ Time Frame: 6-weeks postpartum ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Cleveland ClinicClevelandOhio44195
Amol Malshe
[email protected]
216-903-9646

Find similar trials in Cleveland, OH

By condition
Hypertension (high blood pressure)
By specialty
CardiologyHeart disease
By research site
Cleveland Clinic· Cleveland, OH

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