Clinical Trials at Cleveland Clinic

As of July 2026, 345 paid clinical trials are recruiting at Cleveland Clinic, located at Cleveland Clinic Mellen Center, 1950 E 89th St U Bldg, Cleveland, OH 44195, phone (216) 444-8600 in Cleveland, Ohio. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 13, 2026.

Filter results

Filter results

State

City

Facility

Phase

Study type

Intervention

Recruitment status

Condition

Sex

Age

Healthy volunteers only

345 clinical trials at Cleveland Clinic

·Clear filters·↓ Download CSV

VCRC Tissue Repository

for Aortitis

6 locations incl. Boston

Sponsor: University of Pennsylvania

Sex: All·Age: All ages

Code: NCT02967068·Recruiting

Apply to this trial

Global Multicenter Registry on Transcatheter TRIcuspid Valve RePLACEment

for Tricuspid Regurgitation

5 locations incl. Phoenix

Sponsor: Montefiore Medical Center

Sex: All·Age: 18+

Code: NCT06033274·Recruiting

Apply to this trial

INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)

for Glioblastoma

12 locations incl. Birmingham

Sponsor: Patrick Wen, MD

Sex: All·Age: 18+

Code: NCT02977780·Phase 2·Recruiting

Apply to this trial

PRIMARY Ancillary Substudy

for Mitral Valve Prolapse

16 locations incl. Los Angeles

Sponsor: Annetine Gelijns

Sex: All·Age: 60+

Code: NCT07103733·Recruiting

Apply to this trial

Multi-Center Registry for Peripheral Arterial Disease Interventions and Outcomes

for Peripheral Arterial Disease

24 locations incl. Little Rock

Sponsor: Baylor Research Institute

Sex: All·Age: All ages

Code: NCT01904851·Recruiting

Apply to this trial

Fibrosis Lessens After Metabolic Surgery

for Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD)

4 locations incl. Phoenix

Sponsor: Ali Aminian

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06374875·Phase 4·Recruiting

Apply to this trial

Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell Disease

for Sickle Cell Disease

9 locations incl. Birmingham

Sponsor: RTI International

Sex: All·Age: 18+

Code: NCT06385886·Recruiting

Apply to this trial

Patient-Centered Approach for Treatment Decisions in Mitral Valve Prolapse

for Mitral Valve Prolapse

5 locations incl. Los Angeles

Sponsor: Northwell Health

Sex: All·Age: 21+

Code: NCT06738537·Recruiting

Apply to this trial

Health-Related Quality of Life and Metabolic Outcomes in PCOS

for PCOS (Polycystic Ovary Syndrome)

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: Female·Age: 18 - 49·Accepts healthy volunteers

Code: NCT07571915·Recruiting

Apply to this trial

Centered Surgery - Preoperative Counseling and Patient Satisfaction

for Pelvic Organ Prolapse

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT07471464·Recruiting

Apply to this trial

Humidity Asthma Interventions for Low Socioeconomic Status Children

for Pediatric Asthma

2 locations incl. Cleveland

Sponsor: Case Western Reserve University

Sex: All·Age: Up to 18

Code: NCT07453667·Recruiting

Apply to this trial

Treatment of Antibody-Mediated Rejection (ABMR) With CarBel

for Kidney Transplant Rejection

10 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 75

Code: NCT06918990·Phase 1·Recruiting

Apply to this trial

Healthy Aging in People With Epilepsy Program

for Epilepsy

1 location in Cleveland

Sponsor: Anny Reyes

Sex: All·Age: 55 - 90·Accepts healthy volunteers

Code: NCT06052605·Recruiting

Apply to this trial

Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study

for Hypertension

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: Female·Age: 18+

Code: NCT07363343·Recruiting

Apply to this trial

Deep Brain Stimulation of the Deep Cerebellar Nuclei for Refractory Tremor

for Tremor

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 21+

Code: NCT07049003·Phase 1·Recruiting

Apply to this trial

Bridging the Gap: Educating Patients on Social Determinants of Health to Improve Epilepsy Surgery Access and Outcomes

for Epilepsy

1 location in Cleveland

Sponsor: Anny Reyes

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07509190·Recruiting

Apply to this trial

Metabolic Impacts of Ren-Nu: A Dietary Program for Polycystic Kidney Disease

for Autosomal Dominant Polycystic Kidney Disease (ADPKD)

1 location in Cleveland

Sponsor: Richard Fatica

Sex: All·Age: 18+

Code: NCT07454174·Recruiting

Apply to this trial

Virtual Patient Groups for Sarcoidosis Associated Fatigue

for Sarcoidosis

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT07073963·Recruiting

Apply to this trial

A Superiority Trial of Radiofrequency Ablation for Low Back Pain

for Chronic Low Back Pain (CLBP)

3 locations incl. Atlanta

Sponsor: University of Washington

Sex: All·Age: 18+

Code: NCT07222462·Recruiting

Apply to this trial

Laser Ablation a Salvage Treatment for Obstructive Benign Prostatic Hyperplasia

for Benign Prostatic Hyperplasia (BPH)

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: Male·Age: 40+

Code: NCT07016620·Recruiting

Apply to this trial

Care in Multiple Sclerosis (MS)

for Multiple Sclerosis

6 locations incl. Birmingham

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT07011914·Recruiting

Apply to this trial

Antiseptic-Coated Sutures and Pancreatic Fistula Risk After Pancreatoduodenectomy

for Pancreatoduodenectomy

3 locations incl. Akron

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT07318493·Recruiting

Apply to this trial

Implementation of Intensive Hypertension Management Approaches: Cleveland Clinic

for Hypertension (HTN)

1 location in Cleveland

Sponsor: Anita Misra-Hebert

Sex: All·Age: 18 - 85

Code: NCT07232017·Recruiting

Apply to this trial

Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study

for Post Operative Pain

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 72·Accepts healthy volunteers

Code: NCT07222072·Phase 4·Recruiting

Apply to this trial

CLOSM Trial: Groin Closure Using Layered Option for Suture Material

for Vascular Diseases

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT06990425·Recruiting

Apply to this trial

Early Assessment and Initiation of GuideLine-Directed Evidence-Based Management-HF

for Heart Failure

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 40+

Code: NCT06849752·Recruiting

Apply to this trial

Monocytes in Subjects With Type 1 Diabetes and Chronic Kidney Disease

for Chronic Kidney Disease(CKD)

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 65

Code: NCT06694558·Recruiting

Apply to this trial

Physician Modified Endovascular Grafts for the Treatment of Juxtarenal Aortic Aneurysms

for Juxtarenal Aortic Aneurysm

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT06657794·Recruiting

Apply to this trial

The Management of Necrotizing Soft Tissue Infection Wounds With Cytal® Wound Matrix and MicroMatrix®

for Necrotizing Fascitis

1 location in Cleveland

Sponsor: Benjamin T. Miller

Sex: All·Age: 18+

Code: NCT06857708·Recruiting

Apply to this trial

Sleep Apnea Triggers of Atrial Fibrillation: N-of-1 Randomized Control Trial (SPARTA):

for Afib

2 locations incl. Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 85

Code: NCT07087587·Recruiting

Apply to this trial

CGM for the Early Detection and Management of Hyperglycemia in Pregnancy

for Gestational Diabetes Mellitus in Pregnancy

8 locations incl. Birmingham

Sponsor: Jaeb Center for Health Research

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06957028·Recruiting

Apply to this trial

TIRzepatide for the Treatment of Obesity in Patients With Atrial Fibrillation

for Atrial Fibrillation

Drug: Tirzepatide

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 80

Code: NCT06802081·Phase 2·Recruiting

Apply to this trial

A Study of Ruxolitinib in Combination With Ulixertinib in People With Myelofibrosis

for Myelofibrosis

Drug: Ruxolitinib

9 locations incl. Boston

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06773195·Phase 1, Phase 2·Recruiting

Apply to this trial

Remote Monitoring in Pregnant Women With Congenital Heart Disease Using Wrist Wearables

for Congenital Heart Disease

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: Female·Age: 18+

Code: NCT06818760·Recruiting

Apply to this trial

Impact of Medjool Date Consumption on Labor and Delivery Outcomes

for Spontaneous Labor

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: Female·Age: 18+

Code: NCT07058792·Recruiting

Apply to this trial

Zimmer ActivBraid Rotator Cuff Repair (RCR) Study

for Rotator Cuff Repair of the Shoulder

2 locations incl. Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 75

Code: NCT06971497·Recruiting

Apply to this trial

Effectiveness of Methods for Pyloric Drainage in esophagecTomY: Botox vs. Pyloromyotomy

for Esophageal Cancer Surgery

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT06721520·Phase 2, Phase 3·Recruiting

Apply to this trial

BOOST-PD A Naturalistic Study on IPX-203 for Parkinson's Disease

for Parkinson Disease

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 40+

Code: NCT07138560·Phase 4·Recruiting

Apply to this trial

Pulsed Field Ablation for Post-Infarction Ventricular Tachycardia

for Ventricular Tachycardia

1 location in Cleveland

Sponsor: Pasquale Santangeli

Sex: All·Age: 18+

Code: NCT06891456·Recruiting

Apply to this trial

Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease

for Aortic Regurgitation

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 90

Code: NCT06780241·Recruiting

Apply to this trial