Clinical Trials at Cleveland Clinic

As of August 2026, 320 paid clinical trials are recruiting at Cleveland Clinic, located at 9500 EUCLID AVE # C21, CLEVELAND, OH 44195-0001, phone (216) 444-0522 in Cleveland, Ohio. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 27, 2026.

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322 clinical trials at Cleveland Clinic

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HCMR Re-Imaging Study

for Hypertrophic Cardiomyopathy (HCM)

Sites in Cleveland +5 more locations

Sponsor: Christopher Kramer

Sex: All·Age: 18 - 65

Code: NCT07054073·Recruiting·Listed Jul 2025

Apply to this trial

The Oxford Risk Factors And Non-Invasive Imaging Study

for Cardiovascular Diseases

Sites in Cleveland +11 more locations

Sponsor: University of Oxford

Sex: All·Age: 18 - 99

Code: NCT05169333·Recruiting·Listed Dec 2021

Apply to this trial

Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study

for Post Operative Pain

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 72·Accepts healthy volunteers

Code: NCT07222072·Phase 4·Recruiting·Listed Oct 2025

Apply to this trial

LIVEBETTER: A Trial Comparing Medications in Older Adults With Stable Angina and Multiple Chronic Conditions

for Angina

Sites in Cleveland +9 more locations

Sponsor: Yale University

Sex: All·Age: 65+

Code: NCT05786417·Phase 4·Recruiting·Listed Mar 2023

Apply to this trial

A Multi-Institution Study of TGFβ Imprinted, Ex Vivo Expanded Universal Donor NK Cell Infusions as Adoptive Immunotherapy in Combination With Gemcitabine and Docetaxel in Patients With Relapsed or Refractory Pediatric Bone and Soft Tissue

for Pediatric Sarcoma, Refractory

Sites in Cleveland, Columbus +20 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 2 - 40

Code: NCT05634369·Phase 1, Phase 2·Recruiting·Listed Dec 2022

Apply to this trial

The Management of Necrotizing Soft Tissue Infection Wounds With Cytal® Wound Matrix and MicroMatrix®

for Necrotizing Fascitis

1 location in Cleveland

Sponsor: Benjamin T. Miller

Sex: All·Age: 18+

Code: NCT06857708·Recruiting·Listed Mar 2025

Apply to this trial

Sleep Apnea Triggers of Atrial Fibrillation: N-of-1 Randomized Control Trial (SPARTA):

for Afib

Sites in Cleveland +1 more location

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 85

Code: NCT07087587·Recruiting·Listed Jul 2025

Apply to this trial

JUPITER 4.0 - Risk Factors for Failure of Isolated Medial Patellofemoral Ligament Reconstruction

for Patellar Dislocation, Recurrent

Sites in Cleveland, Dublin +14 more locations

Sponsor: Hospital for Special Surgery, New York

Sex: All·Age: 10 - 35

Code: NCT06883396·Recruiting·Listed Mar 2025

Apply to this trial

North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)

for Mitochondrial Disorders

Sites in Cleveland, Akron +14 more locations

Sponsor: Columbia University

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT01694940·Recruiting·Listed Sep 2012

Apply to this trial

Effect of Limb Length Ratio on Roux-en-Y Gastric Bypass Outcomes (CLIMB II Study)

for Morbid Obesity

1 location in Cleveland

Sponsor: Salvador Navarrete

Sex: All·Age: 18 - 70

Code: NCT06293703·Recruiting·Listed Mar 2024

Apply to this trial

Minimally Invasive Surgery After Neoadjuvant Chemotherapy for the Treatment of Stage IIIC-IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer, LANCE Trial

for Advanced Ovarian Carcinoma

Sites in Cleveland +11 more locations

Sponsor: M.D. Anderson Cancer Center

Sex: Female·Age: 18+

Code: NCT04575935·Phase 3·Recruiting·Listed Oct 2020

Apply to this trial

Visual Function Abnormalities in Strabismus and Amblyopia and Response to Therapy

for Amblyopia

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 6 Months - 90

Code: NCT04310241·Recruiting·Listed Mar 2020

Apply to this trial

Imaging Assessments of ARPKD Kidney Disease Progression

for Autosomal Recessive Polycystic Kidney Disease

Sites in Cleveland +1 more location

Sponsor: The Cleveland Clinic

Sex: All·Age: 6+·Accepts healthy volunteers

Code: NCT07201025·Recruiting·Listed Oct 2025

Apply to this trial

Evaluation of Outcomes of the Triathlon Hinge Knee (THK) System

for Knee Arthropathy

Sites in Cleveland +1 more location

Sponsor: The Cleveland Clinic

Sex: All·Age: All ages

Code: NCT06379321·Recruiting·Listed Apr 2024

Apply to this trial

Effectiveness of Methods for Pyloric Drainage in esophagecTomY: Botox vs. Pyloromyotomy

for Esophageal Cancer Surgery

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT06721520·Phase 2, Phase 3·Recruiting·Listed Dec 2024

Apply to this trial

Left vs Left Randomized Clinical Trial

for Heart Failure

Sites in Cleveland, Cincinnati +55 more locations

Sponsor: Baylor College of Medicine

Sex: All·Age: 18+

Code: NCT05650658·Recruiting·Listed Dec 2022

Apply to this trial

Laser Ablation a Salvage Treatment for Obstructive Benign Prostatic Hyperplasia

for Benign Prostatic Hyperplasia (BPH)

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: Male·Age: 40+

Code: NCT07016620·Recruiting·Listed Jun 2025

Apply to this trial

Remote Monitoring in Pregnant Women With Congenital Heart Disease Using Wrist Wearables

for Congenital Heart Disease

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: Female·Age: 18+

Code: NCT06818760·Recruiting·Listed Feb 2025

Apply to this trial

StrokeNet Thrombectomy Endovascular Platform

for Ischemic Stroke

Sites in Cleveland, Columbus +39 more locations

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06289985·Recruiting·Listed Mar 2024

Apply to this trial

Autologous Bone Marrow Aspirate Treatment for Early-Stage Osteonecrosis

for Osteonecrosis of the Femoral Head

Sites in Cleveland +9 more locations

Sponsor: Johns Hopkins University

Sex: All·Age: 18 - 90

Code: NCT06123481·Recruiting·Listed Nov 2023

Apply to this trial

HOPE Against Cancer Recurrence in HCC

for Liver Transplantation

Sites in Cleveland +1 more location

Sponsor: Philipp Dutkowski

Sex: All·Age: 18+

Code: NCT06717919·Phase 4·Recruiting·Listed Dec 2024

Apply to this trial

Longitudinal Study for Central Nervous System Vasculitis

for Central Nervous System Vasculitis

Sites in Cleveland +3 more locations

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05734404·Recruiting·Listed Feb 2023

Apply to this trial

Multi-Center Registry for Peripheral Arterial Disease Interventions and Outcomes

for Peripheral Arterial Disease

Sites in Cleveland +6 more locations

Sponsor: Baylor Research Institute

Sex: All·Age: All ages

Code: NCT01904851·Recruiting·Listed Jul 2013

Apply to this trial

TIRzepatide for the Treatment of Obesity in Patients With Atrial Fibrillation

for Atrial Fibrillation

Drug: Tirzepatide

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 80

Code: NCT06802081·Phase 2·Recruiting·Listed Jan 2025

Apply to this trial

Comparative Imaging Assessment of Valvular Heart Disease

for Valve Heart Disease

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 90

Code: NCT04126018·Recruiting·Listed Oct 2019

Apply to this trial

Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs

for Liver Diseases

Sites in Cleveland +15 more locations

Sponsor: European Foundation for Study of Chronic Liver Failure

Sex: All·Age: 18 - 80

Code: NCT04613921·Recruiting·Listed Nov 2020

Apply to this trial

Ethanol Induces Skeletal Muscle Autophagy

for Alcoholic Liver Disease

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT03209791·Recruiting·Listed Jul 2017

Apply to this trial

PRIMARY Ancillary Substudy

for Mitral Valve Prolapse

Sites in Cleveland +15 more locations

Sponsor: Annetine Gelijns

Sex: All·Age: 60+

Code: NCT07103733·Recruiting·Listed Aug 2025

Apply to this trial

CGM for the Early Detection and Management of Hyperglycemia in Pregnancy

for Gestational Diabetes Mellitus in Pregnancy

Sites in Cleveland +7 more locations

Sponsor: Jaeb Center for Health Research

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06957028·Recruiting·Listed May 2025

Apply to this trial

Exercise Physiology in Patients With Aortic Aneurysm and Its Correlation With Mechanical Properties of Aortic Tissue

for Aortic Aneurysm

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06789809·Recruiting·Listed Jan 2025

Apply to this trial

Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease

for Aortic Regurgitation

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 90

Code: NCT06780241·Recruiting·Listed Jan 2025

Apply to this trial

Secondary Mitral Regurgitation Treatment With MitraClip and Assessment by Cardiac Magnetic Resonance

for Heart Failure and Reduced Ejection Fraction

Sites in Cleveland, Cincinnati +3 more locations

Sponsor: Minneapolis Heart Institute Foundation

Sex: All·Age: 18+

Code: NCT07131631·Recruiting·Listed Aug 2025

Apply to this trial

Vascular Lab Resource (VLR) Biorepository

for Cardiovascular Diseases

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT05628948·Recruiting·Listed Nov 2022

Apply to this trial

Normal Donor Blood Draws for Platelet Studies and Biomarker Evaluation (ND-PLT)

for Healthy

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 65

Code: NCT05628974·Recruiting·Listed Nov 2022

Apply to this trial

Effects of Assisted Robotic vs Laparoscopic Sleeve Gastrectomy

for Post Operative Pain

1 location in Cleveland

Sponsor: Ricard Corcelles

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT06425016·Recruiting·Listed May 2024

Apply to this trial

Global Multicenter Registry on Transcatheter TRIcuspid Valve RePLACEment

for Tricuspid Regurgitation

Sites in Cleveland +4 more locations

Sponsor: Montefiore Medical Center

Sex: All·Age: 18+

Code: NCT06033274·Recruiting·Listed Sep 2023

Apply to this trial

Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease

for Acute Myocardial Infarction

Sites in Cleveland +12 more locations

Sponsor: Population Health Research Institute

Sex: All·Age: 18+

Code: NCT05701358·Recruiting·Listed Jan 2023

Apply to this trial

Surveillance Trial of the Apple Watch in Reliable Burden Assessment in Unseen Recurrence of Surgically Treated AF

for Atrial Fibrillation

Sites in Cleveland +1 more location

Sponsor: The Cleveland Clinic

Sex: All·Age: 22+

Code: NCT07122947·Recruiting·Listed Aug 2025

Apply to this trial

HMB Enriched Amino Acids to Reverse Muscle Loss in Cirrhosis

for Cirrhosis, Liver

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 21 - 65

Code: NCT05166499·Recruiting·Listed Dec 2021

Apply to this trial

A SkeleTal Muscle Recovery Intervention With Dietary Protein in Heart Failure

for Heart Failure

Sites in Cleveland +1 more location

Sponsor: Tufts Medical Center

Sex: All·Age: 18 - 100

Code: NCT05627440·Recruiting·Listed Nov 2022

Apply to this trial