Clinical Trials at Cleveland Clinic

As of August 2026, 320 paid clinical trials are recruiting at Cleveland Clinic, located at 9500 EUCLID AVE # C21, CLEVELAND, OH 44195-0001, phone (216) 444-0522 in Cleveland, Ohio. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 27, 2026.

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322 clinical trials at Cleveland Clinic

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Molecular Mechanism of Exercise in Cirrhosis

for Cirrhosis, Liver

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 21 - 65

Code: NCT05982769·Recruiting·Listed Aug 2023

Apply to this trial

HA35 Moderate Alcoholic Hepatitis (AH) Study

for Alcoholic Hepatitis

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 21 - 65

Code: NCT05018481·EARLY_Phase 1·Recruiting·Listed Aug 2021

Apply to this trial

HA35 Acute Alcohol Study

for Healthy Controls

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 21 - 65·Accepts healthy volunteers

Code: NCT05025865·EARLY_Phase 1·Recruiting·Listed Aug 2021

Apply to this trial

Maintenance Obinutuzumab in Treating Patients With Central Nervous System Lymphoma Who Have Achieved a Complete or Partial Response

for Primary Central Nervous System Lymphoma

Sites in Cleveland +6 more locations

Sponsor: Providence Health & Services

Sex: All·Age: 18+

Code: NCT06175000·Phase 2·Recruiting·Listed Dec 2023

Apply to this trial

Phenotypic Classification of FMR With CMR

for Nonischemic Congestive Cardiomyopathy

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT05965258·Recruiting·Listed Jul 2023

Apply to this trial

Biliary Anastomosis in Living Donor Liver Transplant With Amniotic Tissue

for Liver Transplant

1 location in Cleveland

Sponsor: Choon Hyuck David Kwon

Sex: All·Age: 18+

Code: NCT07102550·Phase 2·Recruiting·Listed Aug 2025

Apply to this trial

I-Score: Intensive Stroke Cycling for Optimal Recovery and Economic Value

for Stroke

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 85

Code: NCT06585943·Recruiting·Listed Sep 2024

Apply to this trial

B-SAFER: Branched Stented Anastomosis Frozen Elephant Trunk Repair

for Thoracic Aortic Aneurysm

1 location in Cleveland

Sponsor: Eric Roselli, M. D.

Sex: All·Age: 18+

Code: NCT04747626·Recruiting·Listed Feb 2021

Apply to this trial

Mesh Removal Versus No Mesh Removal for Chronic Groin Pain After Inguinal Hernia Repair

for Chronic Groin Pain

1 location in Cleveland

Sponsor: David Krpata

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05484635·Recruiting·Listed Aug 2022

Apply to this trial

Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort

for Huntington's Disease

Sites in Cleveland, Columbus +50 more locations

Sponsor: CHDI Foundation, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT01574053·Recruiting·Listed Apr 2012

Apply to this trial

Intracardiac Echocardiography Guided Watchman Device Implant

for Atrial Fibrillation

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT06007872·Recruiting·Listed Aug 2023

Apply to this trial

Prospective Evaluation of Sequencing From antiCD-20 Therapies to Ozanimod

for Relapsing Multiple Sclerosis

Sites in Cleveland +2 more locations

Sponsor: University of Colorado, Denver

Sex: All·Age: 18+

Code: NCT06529406·Phase 4·Recruiting·Listed Jul 2024

Apply to this trial

Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell Disease

for Sickle Cell Disease

Sites in Cleveland +8 more locations

Sponsor: RTI International

Sex: All·Age: 18+

Code: NCT06385886·Recruiting·Listed Apr 2024

Apply to this trial

Zimmer ActivBraid Rotator Cuff Repair (RCR) Study

for Rotator Cuff Repair of the Shoulder

2 locations in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 75

Code: NCT06971497·Recruiting·Listed May 2025

Apply to this trial

Pulsed Field Ablation for Post-Infarction Ventricular Tachycardia

for Ventricular Tachycardia

1 location in Cleveland

Sponsor: Pasquale Santangeli

Sex: All·Age: 18+

Code: NCT06891456·Recruiting·Listed Mar 2025

Apply to this trial

A Cardiac Disease Quality of Life Study

for Hypertrophic Obstructive Cardiomyopathy

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 70

Code: NCT04080492·Recruiting·Listed Sep 2019

Apply to this trial

Early Diagnosis of Pancreatic Cancer Duodenal Fluid-Based Biomarker Exploratory Study

for Pancreatic Cancers

Sites in Cleveland +1 more location

Sponsor: Do Hyun Park

Sex: All·Age: 19+·Accepts healthy volunteers

Code: NCT07030348·Recruiting·Listed Jun 2025

Apply to this trial

Topical Ruxolitinib Cream for Refractory Cutaneous Dermatomyositis

for Dermatomyositis

Drug: Ruxolitinib

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 89

Code: NCT06857240·Phase 2·Recruiting·Listed Mar 2025

Apply to this trial

Assessment of Coronary Microvascular Dysfunction After STEMI Using Continuous Saline Thermodilution

for ST Elevation Myocardial Infarction

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT06795035·Recruiting·Listed Jan 2025

Apply to this trial

Preventing Injured Knees From osteoArthritis: Severity Outcomes

for Osteoarthritis, Knee

Sites in Cleveland, Columbus +7 more locations

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 45

Code: NCT06096259·Phase 2·Recruiting·Listed Oct 2023

Apply to this trial

The Dragon PLC Trial (DRAGON-PLC)

for Primary Liver Cancer

Sites in Cleveland +4 more locations

Sponsor: Maastricht University

Sex: All·Age: 18+

Code: NCT06914648·Recruiting·Listed Apr 2025

Apply to this trial

Nasal Outcomes Using Saline Irrigations After Endonasal Pituitary Surgery

for Pituitary Tumor

Sites in Cleveland +1 more location

Sponsor: Lori Wood

Sex: All·Age: 19 - 85

Code: NCT05659524·Recruiting·Listed Dec 2022

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Early Versus Late Adjunctive Vasopressin in Septic Shock

for Sepsis

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT06709573·Phase 4·Recruiting·Listed Nov 2024

Apply to this trial

Parkinson's Foundation PD GENEration Genetic Registry

for Parkinson's Disease

Sites in Cleveland, Columbus +51 more locations

Sponsor: Parkinson's Foundation

Sex: All·Age: 18+

Code: NCT04994015·Recruiting·Listed Aug 2021

Apply to this trial

Deep Brain Stimulation Neural Recordings of Varied Stimulation During Sleep in Parkinson's Disease

for Parkinson Disease

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT07110376·Recruiting·Listed Aug 2025

Apply to this trial

Preoperative Pelvic Floor Physical Therapy to Minimize Stress Urinary Incontinence After Holmium Laser Enucleation of the Prostate

for Benign Prostatic Hyperplasia With Outflow Obstruction

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: Male·Age: 18+

Code: NCT06179654·Recruiting·Listed Dec 2023

Apply to this trial

Patient-Centered Approach for Treatment Decisions in Mitral Valve Prolapse

for Mitral Valve Prolapse

Sites in Cleveland +4 more locations

Sponsor: Northwell Health

Sex: All·Age: 21+

Code: NCT06738537·Recruiting·Listed Dec 2024

Apply to this trial

Vertebral Artery Origin Treatment Via Endovascular Techniques Registry (VOTER)

for Vertebral Artery Stenosis

Sites in Cleveland, Toledo +8 more locations

Sponsor: St. Louis University

Sex: All·Age: 18 - 90

Code: NCT03999983·Recruiting·Listed Jun 2019

Apply to this trial

Screening for earlY Heart Failure Diagnosis and Management in Primary Care or at HOme Using Natriuretic Peptides and echocardiographY "SYMPHONY-HF"

for Heart Failure

1 location in Cleveland

Sponsor: NHS Greater Glasgow and Clyde

Sex: All·Age: 40+

Code: NCT05919342·Recruiting·Listed Jun 2023

Apply to this trial

Safety and Efficacy of ARNI After LVAD ImplanT (SEAL-IT) Study

for Stage D Heart Failure

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT04191681·Phase 4·Recruiting·Listed Dec 2019

Apply to this trial

Mako-MORE Registry

for Arthropathy of Knee

Sites in Cleveland +4 more locations

Sponsor: Stryker Orthopaedics

Sex: All·Age: 18+

Code: NCT07647354·Recruiting·Listed Jun 2026

Apply to this trial

Self-Start Triage Model for Post-Botox® Lower Urinary Tract Symptoms

for Overactive Bladder

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: Female·Age: 18+

Code: NCT07648290·EARLY_Phase 1·Recruiting·Listed Jun 2026

Apply to this trial

A Study to Compare Elritercept to Placebo in Adults With Myelofibrosis and Anemia Who Are Taking Ruxolitinib

for Myelofibrosis

Drug: Ruxolitinib

Sites in Cleveland +29 more locations

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT07623161·Phase 3·Recruiting·Listed Jun 2026

Apply to this trial

Pridopidine Phase 3 Study in Huntington's Disease

for Huntington Disease

Sites in Cleveland, Columbus +23 more locations

Sponsor: Prilenia

Sex: All·Age: 23 - 65

Code: NCT07609108·Phase 3·Recruiting·Listed May 2026

Apply to this trial

Neural Mechanisms of Aerobic Exercise Benefits in PD With DBS

for Parkinson's Disease

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT07442747·Phase 2·Recruiting·Listed Mar 2026

Apply to this trial

Empagliflozin to Improve Right Ventricular Function in Pulmonary Arterial Hypertension

for Pulmonary Arterial Hypertension

Drug: Empagliflozin

Sites in Cleveland +2 more locations

Sponsor: Gustavo A Heresi, MD, MS

Sex: All·Age: 18+

Code: NCT06992440·Phase 2·Recruiting·Listed May 2025

Apply to this trial

Prospective Global Registry for the Study of Chronic Total Occlusion Intervention

for Coronary Artery Disease

Sites in Cleveland, Kettering +31 more locations

Sponsor: Minneapolis Heart Institute Foundation

Sex: All·Age: All ages

Code: NCT02061436·Recruiting·Listed Feb 2014

Apply to this trial

Alleviant ALLAY-HFrEF Study

for Heart Failure

Sites in Cleveland, Toledo +37 more locations

Sponsor: Alleviant Medical, Inc.

Sex: All·Age: 18+

Code: NCT06812533·Recruiting·Listed Feb 2025

Apply to this trial

Alleviant ALLAY-HF Study

for Heart Failure

Sites in Cleveland, Toledo +41 more locations

Sponsor: Alleviant Medical, Inc.

Sex: All·Age: 40+

Code: NCT05685303·Recruiting·Listed Jan 2023

Apply to this trial

Longitudinal Validation of CIRC Technologies

for Cardiovascular Diseases

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07081711·Recruiting·Listed Jul 2025

Apply to this trial