Clinical Trials at Cleveland Clinic

As of July 2026, 345 paid clinical trials are recruiting at Cleveland Clinic, located at Cleveland Clinic Mellen Center, 1950 E 89th St U Bldg, Cleveland, OH 44195, phone (216) 444-8600 in Cleveland, Ohio. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 13, 2026.

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345 clinical trials at Cleveland Clinic

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Surveillance Trial of the Apple Watch in Reliable Burden Assessment in Unseen Recurrence of Surgically Treated AF

for Atrial Fibrillation

2 locations incl. St Louis

Sponsor: The Cleveland Clinic

Sex: All·Age: 22+

Code: NCT07122947·Recruiting

Apply to this trial

Imaging Assessments of ARPKD Kidney Disease Progression

for Autosomal Recessive Polycystic Kidney Disease

2 locations incl. Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 6+·Accepts healthy volunteers

Code: NCT07201025·Recruiting

Apply to this trial

Natural History Study of Individuals With Autism and Germline Heterozygous PTEN Mutations

for PTEN

5 locations incl. Los Angeles

Sponsor: Boston Children's Hospital

Sex: All·Age: 18 Months+·Accepts healthy volunteers

Code: NCT02461446·Recruiting

Apply to this trial

Topical Ruxolitinib Cream for Refractory Cutaneous Dermatomyositis

for Dermatomyositis

Drug: Ruxolitinib

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 89

Code: NCT06857240·Phase 2·Recruiting

Apply to this trial

Assessment of Coronary Microvascular Dysfunction After STEMI Using Continuous Saline Thermodilution

for ST Elevation Myocardial Infarction

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT06795035·Recruiting

Apply to this trial

Functional Brain Network Changes in Patients Undergoing Deep Brain Stimulation for Essential Tremor

for Essential Tremor

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 30 - 80·Accepts healthy volunteers

Code: NCT06293638·Recruiting

Apply to this trial

Evaluation of Outcomes of the Triathlon Hinge Knee (THK) System

for Knee Arthropathy

2 locations incl. Weston

Sponsor: The Cleveland Clinic

Sex: All·Age: All ages

Code: NCT06379321·Recruiting

Apply to this trial

Engaging Patients in Prenatal Genetic Testing Decisions as a Pathway to Improve Obstetric Outcomes

for Prenatal Disorder

3 locations incl. Cleveland

Sponsor: The Cleveland Clinic

Sex: Female·Age: 18 - 50

Code: NCT06382636·Recruiting

Apply to this trial

Readiness Brain Operation Optimization Training (ReBOOT) for Epilepsy Surgery

for Epilepsy

1 location in Cleveland

Sponsor: Kayela Arrotta

Sex: All·Age: 18 - 60

Code: NCT05992402·Recruiting

Apply to this trial

Liver Cirrhosis Network Rosuvastatin Efficacy and Safety for Cirrhosis in the United States

for Cirrhosis

13 locations incl. La Jolla

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 18 - 75

Code: NCT05832229·Phase 2·Recruiting

Apply to this trial

Effects of Assisted Robotic vs Laparoscopic Sleeve Gastrectomy

for Post Operative Pain

1 location in Cleveland

Sponsor: Ricard Corcelles

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT06425016·Recruiting

Apply to this trial

Effect of Limb Length Ratio on Roux-en-Y Gastric Bypass Outcomes (CLIMB II Study)

for Morbid Obesity

1 location in Cleveland

Sponsor: Salvador Navarrete

Sex: All·Age: 18 - 70

Code: NCT06293703·Recruiting

Apply to this trial

Cognitive Enhancement Intervention for Creating a Healthy L.I.F.E (Lifestyle Interventions for Epilepsy)

for Epilepsy

1 location in Cleveland

Sponsor: Kayela Arrotta

Sex: All·Age: 18 - 60

Code: NCT05954182·Recruiting

Apply to this trial

Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis

for Lumbar Spinal Stenosis

6 locations incl. Beverly Hills

Sponsor: Columbia University

Sex: All·Age: 50+·Accepts healthy volunteers

Code: NCT06034405·Recruiting

Apply to this trial

Randomized Controlled Trial of Miniaturized Percutaneous Nephrolithotomy With Vacuum-Assisted Access Sheaths Versus Conventional Sheaths for Treatment of Nephrolithiasis

for Kidney Stone

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT05993546·Recruiting

Apply to this trial

Personalized Real-Time DBS and PD Mechanisms

for Parkinson Disease

1 location in Cleveland

Sponsor: David Escobar

Sex: All·Age: 18 - 80

Code: NCT06013956·Phase 4·Recruiting

Apply to this trial

I-Score: Intensive Stroke Cycling for Optimal Recovery and Economic Value

for Stroke

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 85

Code: NCT06585943·Recruiting

Apply to this trial

Subclinical Transthyretin Cardiac Amyloidosis in V122I TTR Carriers

for Amyloidosis, Hereditary

3 locations incl. New York

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 30 - 80

Code: NCT05489549·Recruiting

Apply to this trial

LIVEBETTER: A Trial Comparing Medications in Older Adults With Stable Angina and Multiple Chronic Conditions

for Angina

10 locations incl. New Haven

Sponsor: Yale University

Sex: All·Age: 65+

Code: NCT05786417·Phase 4·Recruiting

Apply to this trial

Belimumab With Rituximab for Primary Membranous Nephropathy

for Membranous Nephropathy

Drug: Rituximab

20 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 75

Code: NCT03949855·Phase 2·Recruiting

Apply to this trial

Trifecta-Kidney cfDNA-MMDx Study

for Kidney Transplant Rejection

11 locations incl. Tampa

Sponsor: University of Alberta

Sex: All·Age: All ages

Code: NCT04239703·Recruiting

Apply to this trial

Gut Flora Metabolite Reduction After Dietary Intervention (GRADY)

for Dietary Modification

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT02016430·Recruiting

Apply to this trial

Randomized Trial of Cold EMR Compared to Hybrid Cold EMR.

for Polyp of Colon

2 locations incl. Weston

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT06937671·Recruiting

Apply to this trial

Genetic Testing to Select Therapy for the Treatment of Advanced or Metastatic Kidney Cancer, OPTIC RCC Study

for Advanced Clear Cell Renal Cell Carcinoma

6 locations incl. Duarte

Sponsor: Vanderbilt-Ingram Cancer Center

Sex: All·Age: 18+

Code: NCT05361720·Phase 2·Recruiting

Apply to this trial

Prospective Evaluation of Sequencing From antiCD-20 Therapies to Ozanimod

for Relapsing Multiple Sclerosis

3 locations incl. Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 18+

Code: NCT06529406·Phase 4·Recruiting

Apply to this trial

Visual Function Abnormalities in Strabismus and Amblyopia and Response to Therapy

for Amblyopia

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 6 Months - 90

Code: NCT04310241·Recruiting

Apply to this trial

Exercise Physiology in Patients With Aortic Aneurysm and Its Correlation With Mechanical Properties of Aortic Tissue

for Aortic Aneurysm

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06789809·Recruiting

Apply to this trial

Biliary Anastomosis in Living Donor Liver Transplant With Amniotic Tissue

for Liver Transplant

1 location in Cleveland

Sponsor: Choon Hyuck David Kwon

Sex: All·Age: 18+

Code: NCT07102550·Phase 2·Recruiting

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Home Versus Office Removal of Percutaneous Nerve Evaluation (PNE) Lead

for Overactive Bladder

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: Female·Age: 18+

Code: NCT05799313·Recruiting

Apply to this trial

Longitudinal Study for Central Nervous System Vasculitis

for Central Nervous System Vasculitis

4 locations incl. Rochester

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05734404·Recruiting

Apply to this trial

Abatacept for the Treatment of Giant Cell Arteritis

for Giant Cell Arteritis

5 locations incl. Rochester

Sponsor: University of Pennsylvania

Sex: All·Age: 50+

Code: NCT04474847·Phase 3·Recruiting

Apply to this trial

Comparative Imaging Assessment of Valvular Heart Disease

for Valve Heart Disease

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 90

Code: NCT04126018·Recruiting

Apply to this trial

Ethanol Induces Skeletal Muscle Autophagy

for Alcoholic Liver Disease

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT03209791·Recruiting

Apply to this trial

The Dragon PLC Trial (DRAGON-PLC)

for Primary Liver Cancer

5 locations incl. New Haven

Sponsor: Maastricht University

Sex: All·Age: 18+

Code: NCT06914648·Recruiting

Apply to this trial

Normal Donor Blood Draws for Platelet Studies and Biomarker Evaluation (ND-PLT)

for Healthy

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 65

Code: NCT05628974·Recruiting

Apply to this trial

Vascular Lab Resource (VLR) Biorepository

for Cardiovascular Diseases

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT05628948·Recruiting

Apply to this trial

Molecular Mechanism of Exercise in Cirrhosis

for Cirrhosis, Liver

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 21 - 65

Code: NCT05982769·Recruiting

Apply to this trial

A SkeleTal Muscle Recovery Intervention With Dietary Protein in Heart Failure

for Heart Failure

2 locations incl. Boston

Sponsor: Tufts Medical Center

Sex: All·Age: 18 - 100

Code: NCT05627440·Recruiting

Apply to this trial

Phenotypic Classification of FMR With CMR

for Nonischemic Congestive Cardiomyopathy

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT05965258·Recruiting

Apply to this trial

HA35 Moderate Alcoholic Hepatitis (AH) Study

for Alcoholic Hepatitis

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 21 - 65

Code: NCT05018481·EARLY_Phase 1·Recruiting

Apply to this trial