Longitudinal Validation of CIRC Technologies

Part of paid clinical trials in Cleveland, Ohio.

Sponsor: The Cleveland Clinic
Study ID: NCT07081711
Status: Recruiting

Conditions

Aortic Diseases
Atrial Fibrillation
Cardiovascular Diseases
Congenital Heart Disease
Heart Failure
Ischemic Heart Disease
Metabolic Cardiomyopathy
Non-ischemic Cardiomyopathy
Valvular Heart Disease
Ventricular Fibrillation

Eligibility Criteria

Sex: ALL
Age: 18 Years - N/A
Healthy Volunteers: Accepted

Study Details

Cardiovascular disease is the leading cause of death worldwide. Advanced cardiovascular imaging using Magnetic Resonance Imaging (MRI) has proven to be effective in providing gold standard myocardial tissue characterization. Moreover, the intrinsic advantage of MRI's lack of exposure to ionizing radiation is particularly beneficial. At the same time, blood work can be very useful in early detection of certain cardiomyopathy, such as amyloid. However, there is a lack of agreement of on which markers are the most sensitive. This multi-study will allow the unique opportunity to form a more comprehensive understanding for various cardiovascular diseases. The study team has developed novel cardiac MRI techniques that leverages endogenous tissue properties to reveal a milieu of deep tissue phenotypes including myocardial inflammation, fibrosis, metabolism, and microstructural defects. Among these phenotypes, myocardial microstructure has proven to be most sensitive to early myocardial tissue damage and is predictive of myocardial regeneration. In this study, the investigators aim to further study the importance of cardiac microstructure revealed by MRI in patient and healthy population and compare this novel technology with conventional clinical biomarkers.

Key Dates

First listed: Jul 23, 2025
Start date: May 6, 2026
Status verified: Mar 2026
Primary completion: Aug 31, 2035
Completion: Aug 31, 2037

Study Design

Enrollment: 1,000 participants (estimated)

Arms

Arm: Healthy Volunteer
Subjects without cardiovascular disease
Arm: Cardiovascular Disease Patients
Patients with known or suspected cardiovascular disease