Paid Clinical Trials in Columbia, MD

As of August 2026, 80 paid clinical trials are recruiting in Columbia, Maryland. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 10, 2026.

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77 clinical trials

A Study of AK117 in Combination With Azacitidine in Patients With Myelodysplastic Syndromes

for Higher-risk Myelodysplastic Syndromes

Sites in Columbia, Bethesda +12 more locations

Sponsor: Akeso

Sex: All·Age: 18+

Code: NCT06196203·Phase 2·Recruiting·Listed Jan 2024

Apply to this trial

A Study to Assess the Efficacy and Safety of Efgartigimod PH20 SC in Adults With Systemic Sclerosis

for Systemic Sclerosis (SSc)

Drug: Efgartigimod PH20 SC

Sites in Columbia, Baltimore +7 more locations

Sponsor: argenx

Sex: All·Age: 18+

Code: NCT06655155·Phase 2·Recruiting·Listed Oct 2024

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MagnetOs Flex Matrix Compared to Trinity Elite Mixed With Local Autograft in Patients Undergoing up to Four-level Instrumented Posterolateral Fusion

for Degenerative Disc Disease

Sites in Columbia +7 more locations

Sponsor: Kuros Biosurgery AG

Sex: All·Age: 18+

Code: NCT05037968·Recruiting·Listed Sep 2021

Apply to this trial

FiberLocker® System Augmentation of Rotator Cuff Repairs

for Rotator Cuff Tear

Sites in Columbia +3 more locations

Sponsor: ZuriMED Technologies Inc.

Sex: All·Age: 30 - 70

Code: NCT06918041·Recruiting·Listed Apr 2025

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A Study of Selinexor Monotherapy in Subjects With JAK Inhibitor-naïve Myelofibrosis and Moderate Thrombocytopenia

for Myelofibrosis

Drug: Selinexor

Sites in Columbia +6 more locations

Sponsor: Karyopharm Therapeutics Inc

Sex: All·Age: 18+

Code: NCT05980806·Phase 2·Recruiting·Listed Aug 2023

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A Study to Assess Real-world Patient Characteristics and Clinical Course for Symptomatic Patients With PKP2-ACM

for Arrhythmogenic Cardiomyopathy

Sites in Columbia, Baltimore +4 more locations

Sponsor: Lexeo Therapeutics

Sex: All·Age: 18 - 65

Code: NCT06976606·Recruiting·Listed May 2025

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Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer

for Locally Advanced Cervical Adenocarcinoma

Sites in Columbia, Glen Burnie +303 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT07061977·Phase 3·Recruiting·Listed Jul 2025

Apply to this trial

E-Mindfulness Approaches for Living After Breast Cancer

for Breast Cancer

Sites in Columbia, Olney +372 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18 - 50

Code: NCT06748222·Phase 3·Recruiting·Listed Dec 2024

Apply to this trial

Treatment of Inflammatory Myelitis and Optic Neuritis With Early vs Rescue Plasma Exchange (TIMELY-PLEX)

for Optic Neuritis

Sites in Columbia, Baltimore +27 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07100990·Phase 3·Recruiting·Listed Aug 2025

Apply to this trial

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

for Prostate Adenocarcinoma

Sites in Columbia, Glen Burnie +397 more locations

Sponsor: NRG Oncology

Sex: Male·Age: 18+

Code: NCT05946213·Phase 3·Recruiting·Listed Jul 2023

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Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

for Anatomic Stage IV Breast Cancer AJCC v8

Sites in Columbia, Glen Burnie +255 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06500455·Phase 3·Recruiting·Listed Jul 2024

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Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

for Recurrent Head and Neck Squamous Cell Carcinoma

Sites in Columbia, Glen Burnie +127 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 79

Code: NCT04671667·Phase 2·Recruiting·Listed Dec 2020

Apply to this trial

A Study of Fruquintinib Plus FOLFIRI as Second-Line Treatment for Participants With Metastatic Colorectal Cancer (FRUITFUL)

for Colon Cancer

Sites in Columbia +13 more locations

Sponsor: SCRI Development Innovations, LLC

Sex: All·Age: 18+

Code: NCT07011576·Phase 2·Recruiting·Listed Jun 2025

Apply to this trial

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

for Stage I Breast Cancer

Sites in Columbia, Glen Burnie +705 more locations

Sponsor: NRG Oncology

Sex: All·Age: 50 - 70

Code: NCT04852887·Phase 3·Recruiting·Listed Apr 2021

Apply to this trial

Testing the Pain Clinical Practice Guideline

for Pain

Sites in Columbia & Timonium

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 60+

Code: NCT05858996·Phase 2·Recruiting·Listed May 2023

Apply to this trial

Outpatient Administration of Teclistamab or Talquetamab for Multiple Myeloma

for Multiple Myeloma

Drug: Talquetamab

Sites in Columbia +15 more locations

Sponsor: SCRI Development Innovations, LLC

Sex: All·Age: 18+

Code: NCT05972135·Phase 2·Recruiting·Listed Aug 2023

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Measuring the Effects of Netarsudil, Latanoprost, and Combination Therapy on Episcleral and Retinal Blood Flow in Ocular Hypertension and Glaucoma Suspects

for Ocular Hypertension

Sites in Columbia, Baltimore & Silver Spring

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18+

Code: NCT04401982·Phase 4·Recruiting·Listed May 2020

Apply to this trial

TERPS Trial for de Novo Oligometastic Prostate Cancer

for Prostate Cancer

Sites in Columbia, Glen Burnie +8 more locations

Sponsor: University of Maryland, Baltimore

Sex: Male·Age: 18+

Code: NCT05223803·Phase 2·Recruiting·Listed Feb 2022

Apply to this trial

LITT Followed by Hypofractionated RT for Newly Diagnosed Gliomas (GCC 20138)

for Glioma

Sites in Columbia, Glen Burnie +3 more locations

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18+

Code: NCT04699773·Recruiting·Listed Jan 2021

Apply to this trial

Inherited Retinal Degenerative Disease Registry

for Eye Diseases Hereditary

1 location in Columbia

Sponsor: Foundation Fighting Blindness

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT02435940·Recruiting·Listed May 2015

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Study of Tucatinib and Doxil in Participants With Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Metastatic Breast Cancer

for Breast Cancer

Sites in Columbia +6 more locations

Sponsor: SCRI Development Innovations, LLC

Sex: All·Age: 18+

Code: NCT05748834·Phase 2·Recruiting·Listed Mar 2023

Apply to this trial

Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

for Metastatic Lung Small Cell Carcinoma

Sites in Columbia, Glen Burnie +146 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT04804644·Phase 3·Recruiting·Listed Mar 2021

Apply to this trial

GammaPod Registry and Quality of Life Nomogram

for Breast Cancer Female

Sites in Columbia, Glen Burnie +2 more locations

Sponsor: University of Maryland, Baltimore

Sex: Female·Age: 18+

Code: NCT03562273·Recruiting·Listed Jun 2018

Apply to this trial

GammaPod Dose Escalation Radiation for Early Stage Breast Cancer

for Breast Cancer

Sites in Columbia, Glen Burnie +2 more locations

Sponsor: University of Maryland, Baltimore

Sex: Female·Age: 45+

Code: NCT04234386·Recruiting·Listed Jan 2020

Apply to this trial

LITT Followed by Hypofractionated RT for Recurrent Gliomas

for Glioblastoma

Sites in Columbia, Glen Burnie +2 more locations

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 22+

Code: NCT04181684·Recruiting·Listed Nov 2019

Apply to this trial

Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Circulating Tumor DNA Levels (SAVAL)

for Head and Neck Cancer

Sites in Columbia, Glen Burnie +3 more locations

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18+

Code: NCT06088381·Phase 2·Recruiting·Listed Oct 2023

Apply to this trial

Brief Motivational Interviewing +/- Mindfulness Training for Adolescent Alcohol Use in Pediatric Primary Care

for Adolescent Alcohol Use

Sites in Columbia, Odenton +11 more locations

Sponsor: Johns Hopkins University

Sex: All·Age: 12 - 17

Code: NCT07059078·Recruiting·Listed Jul 2025

Apply to this trial

Surgeon-Initiated Bone Health Referral Pathway in Patients Undergoing Lower Extremity Arthroplasty

for Osteoporosis

1 location in Columbia

Sponsor: Johns Hopkins University

Sex: All·Age: 50+·Accepts healthy volunteers

Code: NCT05845021·Recruiting·Listed May 2023

Apply to this trial

Efficacy Trial of the CALM Intervention

for Anxiety Disorder of Childhood

Sites in Columbia +1 more location

Sponsor: UConn Health

Sex: All·Age: 5 - 12

Code: NCT04693858·Recruiting·Listed Jan 2021

Apply to this trial

A Phase 3 Study of INCA033989 Versus Best Available Therapy in Participants With Essential Thrombocythemia

for Essential Thrombocythemia

Sites in Columbia, Baltimore +39 more locations

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT07623200·Phase 3·Recruiting·Listed Jun 2026

Apply to this trial

A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event

for Cardiovascular Disease

Sites in Columbia, Beltsville +294 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07000357·Phase 3·Recruiting·Listed Jun 2025

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A Study of Surovatamig (AZD0486) Plus Rituximab in Previously Untreated Follicular Lymphoma Patients

for Untreated Follicular Lymphoma

Drug: Rituximab

Sites in Columbia, Baltimore +51 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06549595·Phase 3·Recruiting·Listed Aug 2024

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A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)

for Breast Cancer

Drug: Durvalumab

Sites in Columbia +35 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06103864·Phase 3·Recruiting·Listed Oct 2023

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A Phase 3 Study to Evaluate Petosemtamab Compared With Investigator's Choice Monotherapy in Previously Treated Head and Neck Squamous Cell Carcinoma Patients (LiGeR-HN2)

for Head and Neck Squamous Cell Carcinoma

Drug: Petosemtamab

Sites in Columbia +60 more locations

Sponsor: Merus B.V.

Sex: All·Age: 18+

Code: NCT06496178·Phase 3·Recruiting·Listed Jul 2024

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A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)

for Chronic Obstructive Pulmonary Disease (COPD)

Sites in Columbia, Baltimore +61 more locations

Sponsor: AstraZeneca

Sex: All·Age: 40 - 80

Code: NCT06883305·Phase 3·Recruiting·Listed Mar 2025

Apply to this trial

A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma

for Neoplasms, Head and Neck

Drug: Dostarlimab

Sites in Columbia +30 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT06256588·Phase 3·Recruiting·Listed Feb 2024

Apply to this trial