LITT Followed by Hypofractionated RT for Newly Diagnosed Gliomas (GCC 20138)

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
University of Maryland, Baltimore
Study ID
NCT04699773
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • LITT — PROCEDURE
    This procedure is done under MRI guidance and employs low-powered thermal energy to achieve tumor ablation through coagulation.
  • Hypofractionated Radiation Therapy — RADIATION
    Treatments will be delivered once daily on consecutive treatment days (typically 5 fractions per week). Radiation therapy simulation is to be performed within 10 days of the LITT procedure.

Study Details

The purpose of this study is to evaluate the treatment regimen of using Laser Interstitial Thermal Therapy (LITT) and Hypo-fractionated Radiation Therapy to treat patients with newly diagnosed gliomas.

Key Dates

First listed
Jan 7, 2021
Start date
Feb 20, 2021
Status verified
May 2026
Primary completion
Feb 28, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
32 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: LITT with Hypofractionated RT
    Laser interstitial thermal therapy (LITT) followed by hypo-fractionated radiation therapy, 25Gy/10 fractions.

Primary Outcome Measure

Adverse Events [ Time Frame: 2 years ]

Central Contacts

Locations (5)

FacilityCityStateZIPSite coordinators
Maryland Proton Treatment CenterBaltimoreMaryland21201
Mark Mishra, MD
[email protected]
4103286080
Caitlin Eggleston, BS
[email protected]
410-328-7586
University of Maryland Greenebaum Cancer CenterBaltimoreMaryland21201
Mark Mishra, MD
[email protected]
410-328-6080
Caitlin Eggleston, BS
[email protected]
410-328-6080
Graeme Woodworth, MD (SUB_INVESTIGATOR)
UCH Kaufman Cancer CenterBel AirMaryland21014
Mark Mishra, MD
410-328-6080
Linda Romar
[email protected]
Central Maryland Radiation OncologyColumbiaMaryland21044
Mark Mishra, MD
410-328-6080
Caitlin Eggleston
[email protected]
Baltimore Washington Medical CenterGlen BurnieMaryland21061
Mark Mishra, MD
[email protected]
410-328-6080
Pilar Strycula
[email protected]

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Maryland Proton Treatment Center· Baltimore, MDUniversity of Maryland Greenebaum Cancer Center· Baltimore, MDUCH Kaufman Cancer Center· Bel Air, MDCentral Maryland Radiation Oncology· Columbia, MDBaltimore Washington Medical Center· Glen Burnie, MD

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