Clinical Trials at Nationwide Children's Hospital

As of August 2026, 171 paid clinical trials are recruiting at Nationwide Children's Hospital, located at 700 CHILDRENS DR, COLUMBUS, OH 43205-2696, phone (614) 355-2103 in Columbus, Ohio. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 31, 2026.

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174 clinical trials at Nationwide Children's Hospital

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Combination Therapy for the Treatment of Diffuse Midline Gliomas

for Diffuse Intrinsic Pontine Glioma

Sites in Columbus +18 more locations

Sponsor: University of California, San Francisco

Sex: All·Age: 2 - 39

Code: NCT05009992·Phase 2·Recruiting·Listed Aug 2021

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NANT 2021-01 Phase II STING (Sequential Temozolomide, Irinotecan, NK Cells and GD2 mAb) Trial

for Neuroblastoma

Drug: Irinotecan

Sites in Columbus, Cincinnati +11 more locations

Sponsor: New Approaches to Neuroblastoma Therapy Consortium

Sex: All·Age: 1 - 31

Code: NCT06450041·Phase 2·Recruiting·Listed Jun 2024

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A Single-Stage, Adaptive, Open-label, Dose Escalation Safety and Efficacy Study of AADC Deficiency in Pediatric Patients

for AADC Deficiency

Sites in Columbus +2 more locations

Sponsor: Krzysztof Bankiewicz

Sex: All·Age: 24 Months+

Code: NCT02852213·Phase 1·Recruiting·Listed Aug 2016

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Optimizing Pain Treatment in Children On Mechanical Ventilation

for Mechanical Ventilation

Sites in Columbus, Cleveland +14 more locations

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 2 Months - 17

Code: NCT06994442·Phase 3·Recruiting·Listed May 2025

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Childhood Cancer Survivor Study

for Cancer

Sites in Columbus +26 more locations

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT01120353·Recruiting·Listed May 2010

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Comparing Two School-Based Sleep Health Interventions To Promote Sleep Quality in Youth

for Sleep

Sites in Columbus +1 more location

Sponsor: Children's Hospital Los Angeles

Sex: All·Age: 12 - 18·Accepts healthy volunteers

Code: NCT07213908·Recruiting·Listed Oct 2025

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Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

for High Grade Glioma

Sites in Columbus, Cincinnati +8 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 1 - 21·Accepts healthy volunteers

Code: NCT06333899·EARLY_Phase 1·Recruiting·Listed Mar 2024

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The Diaphragmatic Initiated Ventilatory Assist (DIVA) Trial

for Extubation Failure

Sites in Columbus +15 more locations

Sponsor: University of Pennsylvania

Sex: All·Age: 0 Days - 9 Weeks

Code: NCT05446272·Recruiting·Listed Jul 2022

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Trial of Sequential Medications AfteR TNFi Failure in Juvenile Idiopathic Arthritis

for Polyarticular Course Juvenile Idiopathic Arthritis (JIA)

Sites in Columbus +3 more locations

Sponsor: Duke University

Sex: All·Age: 2 - 17

Code: NCT06654882·Phase 3·Recruiting·Listed Oct 2024

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Clinical, Imaging, and Endoscopic Outcomes of Children Newly Diagnosed With Crohn's Disease

for Crohn Disease

Sites in Columbus, Cincinnati +19 more locations

Sponsor: Connecticut Children's Medical Center

Sex: All·Age: 6 - 17

Code: NCT05781152·Phase 4·Recruiting·Listed Mar 2023

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I-DECIDE After Bronchiolitis Hospitalization

for Bronchiolitis Acute

Sites in Columbus, Dayton +54 more locations

Sponsor: Seattle Children's Hospital

Sex: All·Age: 0 Months - 24 Months

Code: NCT07243652·Recruiting·Listed Nov 2025

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Hyperhydration in Children With Shiga Toxin-Producing E. Coli Infection

for Shiga Toxin-Producing Escherichia Coli (E. Coli) Infection

Sites in Columbus, Cincinnati +20 more locations

Sponsor: University of Calgary

Sex: All·Age: 9 Months - 21

Code: NCT05219110·Recruiting·Listed Feb 2022

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AI-Based Personalized Health and Self-Care

for Social Needs Status

1 location in Columbus

Sponsor: Emre Sezgin

Sex: All·Age: All ages

Code: NCT07168382·Recruiting·Listed Sep 2025

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Safety Study of Unlicensed IND Cord Blood Units Manufactured by the National Cord Blood Program for Unrelated Transplantation

for Infusion Reactions

Sites in Columbus, Cincinnati +58 more locations

Sponsor: New York Blood Center

Sex: All·Age: All ages

Code: NCT01656603·Phase 2·Recruiting·Listed Aug 2012

Apply to this trial

Survivors Journey+

for Pediatric Brain Tumor

Sites in Columbus & Cincinnati

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 15 - 25

Code: NCT07321353·Recruiting·Listed Jan 2026

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HCRN Core Data Project: Characterizing Patient Populations in the Hydrocephalus Clinical Research Network (HCRN)

for Pediatric Hydrocephalus

Sites in Columbus +10 more locations

Sponsor: University of Utah

Sex: All·Age: Up to 18

Code: NCT00670735·Recruiting·Listed May 2008

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Congenital Heart Disease Physical Activity Lifestyle Study V.2

for Heart Defects, Congenital

1 location in Columbus

Sponsor: Jamie Jackson

Sex: All·Age: 15 - 25

Code: NCT06003023·Recruiting·Listed Aug 2023

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Ketamine add-on Therapy for Established Status Epilepticus Treatment Trial (KESETT)

for Status Epilepticus

Sites in Columbus, Cincinnati +50 more locations

Sponsor: University of Virginia

Sex: All·Age: 1+

Code: NCT06907173·Phase 3·Recruiting·Listed Apr 2025

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Genetically Engineered Cells (Anti-CD19/CD20/CD22 CAR T-cells) for the Treatment of Relapsed or Refractory Lymphoid Malignancies

for Recurrent Acute Lymphoblastic Leukemia

2 locations in Columbus

Sponsor: Sumithira Vasu

Sex: All·Age: 2+

Code: NCT05418088·Phase 1·Recruiting·Listed Jun 2022

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DISCOVERY of Risk Factors for Type 2 Diabetes in Youth

for Diabetes Mellitus Type 2, Childhood-Onset

Sites in Columbus, Cincinnati +18 more locations

Sponsor: George Washington University

Sex: All·Age: 8 - 15

Code: NCT06525259·Recruiting·Listed Jul 2024

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Precise Infliximab Exposure and Pharmacodynamic Control

for Crohn Disease

Sites in Columbus, Cincinnati +9 more locations

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 6 - 22

Code: NCT05660746·Phase 2, Phase 3·Recruiting·Listed Dec 2022

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Comparison of Uncomplicated Candidemia Therapy Duration in Children

for Invasive Candidiasis

Sites in Columbus, Cincinnati +19 more locations

Sponsor: Arkansas Children's Hospital Research Institute

Sex: All·Age: 120 Days+

Code: NCT05763251·Recruiting·Listed Mar 2023

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Targeted Pediatric High-Grade Glioma Therapy

for High Grade Glioma

Sites in Columbus, Cincinnati +9 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 12 Months - 39

Code: NCT05839379·Recruiting·Listed May 2023

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Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

for High Grade Glioma

Drug: Ribociclib

Sites in Columbus, Cincinnati +9 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 12 Months - 39

Code: NCT05843253·Phase 2·Recruiting·Listed May 2023

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Supraglottic Airway for Resuscitation Trial

for Neonatal Resuscitation

Sites in Columbus, Cincinnati +28 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 0 Days+

Code: NCT07150923·Recruiting·Listed Sep 2025

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Neonatal Platelet Transfusion Threshold Trial

for Thrombocytopenia

Sites in Columbus, Cincinnati +18 more locations

Sponsor: NICHD Neonatal Research Network

Sex: All·Age: 1 Hour - 48 Hours·Accepts healthy volunteers

Code: NCT06676904·Recruiting·Listed Nov 2024

Apply to this trial

ACTEMRA® for the Treatment of Pediatric Adamantinomatous Craniopharyngioma

for Adamantinomatous Craniopharyngioma

Sites in Columbus, Cincinnati +5 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 1 - 39

Code: NCT05233397·Phase 2·Recruiting·Listed Feb 2022

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Comparing a Team-Based Approach to Standard Well-Child Visits To Improve Preventive Care Services

for Pediatric

1 location in Columbus

Sponsor: Seattle Children's Hospital

Sex: All·Age: 9 Months - 15 Months·Accepts healthy volunteers

Code: NCT05852392·Recruiting·Listed May 2023

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Feasibility of Aerodigestive Stimulation Therapy Trial

for Feeding Disorder Neonatal

1 location in Columbus

Sponsor: Sudarshan Jadcherla

Sex: All·Age: 1 Day - 8 Months

Code: NCT06118697·Recruiting·Listed Nov 2023

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Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS

for Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS)

Sites in Columbus, Cincinnati +30 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 1 Day - 17

Code: NCT05267821·Phase 2, Phase 3·Recruiting·Listed Mar 2022

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MEKTOVI® for the Treatment of Pediatric Adamantinomatous Craniopharyngioma

for Adamantinous Craniopharyngioma

Sites in Columbus, Cincinnati +3 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 1 - 39

Code: NCT05286788·Phase 2·Recruiting·Listed Mar 2022

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Pediatric Cochlear Implant Remote Programming and Assessment

for Cochlear Implant Listeners

1 location in Columbus

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 13 - 20

Code: NCT07035873·Recruiting·Listed Jun 2025

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GpCRC Pediatric Gastroparesis Registry 2

for Gastroparesis

Sites in Columbus +5 more locations

Sponsor: Johns Hopkins Bloomberg School of Public Health

Sex: All·Age: 8 - 25

Code: NCT05981300·Recruiting·Listed Aug 2023

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Re-Engaging AYA Survivors in Cancer-Related Healthcare

for Cancer

Sites in Columbus +2 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 15 - 29

Code: NCT07138040·Recruiting·Listed Aug 2025

Apply to this trial

Neuroblastoma Biology Study

for Neuroblastoma

Sites in Columbus, Cincinnati +12 more locations

Sponsor: New Approaches to Neuroblastoma Therapy Consortium

Sex: All·Age: 31 Days - 99

Code: NCT01587300·Recruiting·Listed Apr 2012

Apply to this trial

Genetics of Congenital Heart Disease

for Congenital Heart Disease

1 location in Columbus

Sponsor: Nationwide Children's Hospital

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT01192048·Recruiting·Listed Aug 2010

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A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

for High Grade Glioma

Sites in Columbus, Cincinnati +7 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: Up to 21

Code: NCT04655404·EARLY_Phase 1·Recruiting·Listed Dec 2020

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A Multi-Institution Study of TGFβ Imprinted, Ex Vivo Expanded Universal Donor NK Cell Infusions as Adoptive Immunotherapy in Combination With Gemcitabine and Docetaxel in Patients With Relapsed or Refractory Pediatric Bone and Soft Tissue

for Pediatric Sarcoma, Refractory

Sites in Columbus, Cleveland +20 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 2 - 40

Code: NCT05634369·Phase 1, Phase 2·Recruiting·Listed Dec 2022

Apply to this trial

DOSC and Association With Neighborhood Opportunity: Phase II

for Pediatric Day of Surgery Cancellations

1 location in Columbus

Sponsor: Nationwide Children's Hospital

Sex: All·Age: Up to 18·Accepts healthy volunteers

Code: NCT05939570·Recruiting·Listed Jul 2023

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Improving Status Epilepticus Treatment Times

for Status Epilepticus

1 location in Columbus

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 30 Days - 18

Code: NCT06194747·Recruiting·Listed Jan 2024

Apply to this trial